Usefulness of endomyocardial biopsy for the diagnosis of dilated cardiomyopathy

• Project/Area Number: 26461073
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Nagasaki University
• Principal Investigator: KAWANO Hiroaki 長崎大学, 医歯薬学総合研究科(医学系), 准教授 (30325659)
• Co-Investigator(Kenkyū-buntansha): 蒔田 直昌 長崎大学, 医歯薬学総合研究科(医学系), 教授 (00312356)
• Co-Investigator(Renkei-kenkyūsha): MAEMURA Koji 長崎大学, 医歯薬学総合研究科(医学系), 教授 (90282649) ; FUKUOKA Junya 長崎大学, 医歯薬学総合研究科(医学系), 教授 (00324575) ; ABE Kuniko 長崎大学, 病院(医学系), 准教授 (00253641) ; EISHI Kiyoyuki 長崎大学, 医歯薬学総合研究科(医学系), 教授 (20167290)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2014: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: 心筋症 / 心筋生検 / 免疫染色 / 電子顕微鏡 / 拡張型心筋症 / 遺伝子解析 / 心不全 / プラコグロビン

Outline of Final Research Achievements

Dilated cardiomyopathy (DCM) is a refractory disease whose diagnosis is not easy because its causes are various. We studied about usefulness of endomyocardial biopsy for the diagnosis of dilated cardiomyopathy. Immunostaining of myocardial structural proteins makes the diagnosis of specific cardiomyopathy such as arrhythmogenic right ventricular cardiomyopathy. We are able to investigate the pathogenesis of DCM by evaluation of sarcomere structure using electron microscopy. Moreover, necessary gene analysis in addition to pathogical diagnosis and clinical characteristics allows us to diagnosis lamin cardiomyopathy. Finally, those data is useful for the selection of therapy for several type of DCM.

Research Products

• [Journal Article] The Histological Features of a Myocardial Biopsy Specimen in a Patient in the Acute Phase of Reversible Catecholamine-induced Cardiomyopathy due to Pheochromocytoma (2017)
  • Author(s): Miura M, Kawano H, Yoshida T, Yamagata Y, Nakata T, Koga S, Ikeda S, Kageyama K, Abe K, Maemura K
  • Journal Title: Internal Medicine Volume: 56 Issue: 6 Pages: 665-671
  • DOI: 10.2169/internalmedicine.56.7454
  • NAID: 130005450365
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Journal Article] Myocardial fragmentation associated with disruption of the Z-band in hypertrophic cardiomyopathy in Noonan syndrome. (2016)
  • Author(s): Kawano H, Kawamura K, Ishijima M, Hayashi T, Abe K, Kawai K, Maemura K.
  • Journal Title: Cardiovasc Pathol Volume: 25 Issue: 4 Pages: 329-332
  • DOI: 10.1016/j.carpath.2016.05.001
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Diverse Findings in Calcified Thrombus Between Histopathology and <i>In Vivo</i> Imaging Including Intravascular Ultrasound, Optical Coherence Tomography, and Angioscopy (2015)
  • Author(s): Yoshida T, Kawano H, Kusumoto S, Fukae S, Koga S, Ikeda S, Koide Y, Abe K, Hayashi T, Maemura K.
  • Journal Title: International Heart Journal Volume: 56 Issue: 6 Pages: 661-663
  • DOI: 10.1536/ihj.15-117
  • NAID: 130005113059
  • ISSN: 1349-2365, 1349-3299
  • Peer Reviewed
• [Presentation] 拡張型心筋症の心筋生検病理所見からみた病態と運動耐容能について (2016)
  • Author(s): 河野浩章、米倉 剛 、赤司良平、森本陽介、矢野雄大 、前村浩二
  • Organizer: 日本心臓リハビリテーション学会
  • Place of Presentation: 東京国際フォーラム（東京都千代田区）
  • Year and Date: 2016-07-16