| Project/Area Number |
26461076
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
北村 和雄 宮崎大学, 医学部, 教授 (50204912)
畠山 金太 奈良県立医科大学, 医学部, 准教授 (60325735)
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| Co-Investigator(Renkei-kenkyūsha) |
UDAGAWA Nobuyuki 松本歯科大学, 歯学部, 教授 (70245801)
SEKIMOTO Tomohisa 宮崎大学, 医学部, 助教 (60305000)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 心不全 / 骨粗鬆症 / 加齢 / 線維化 / アポトーシス / 高血圧 / アンジオテンシン / 骨粗鬆 |
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| Outline of Final Research Achievements |
Main purpose of this study was to elucidate the possible roles for osteoprotegerin (OPG) in the development of heart failure. In 52-week-old OPG-/- mice, we found that the OPG-/- mice displayed higher blood pressure than wild-types. In addition, OPG-/- mice revealed left ventricular dilation concomitant with reduction in left ventricular contractility. In histological analysis, OPG-/- mice showed infrequent fibrosis for its heart size. Furthermore, we administered angiotensin II to 8-week-old OPG-/- mice and wild-type mice, and we found the exaggerated left ventricular hypertrophy with the impaired left ventricular contractility. Recombinant OPG to these mice partially improved the phenomena. Taken together, our results suggest that OPG may have additive effects on cardiac structure and function associated with aging and hypertension.
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