| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Using a complementary metal-oxide semiconductor image sensor (CMOS) camera and a 16 X 16-element photodiode array together with a voltage-sensitive absorption dye (NK2761), we optically mapped the spread of excitation during experimental tachyarrhythmia (tachycardia-like excitation, TE) in the isolated rat atrial preparation, in order to elucidate the basic pathoelectrophysiological phenomena during the arrhythmia. Using the CMOS camera which was newly introduced to this study, chaotic spread of excitation during TE was visualized by movies. During the event of "chaotic" TE, fragmented excitatory waves (wavelets) propagated irregularly with unstable blocked areas which blocked the excitation spread, unstable micro re-entry circuits and/or unstable foci of abnormal automatism. We consider that these patterns may mimic the electrical activities during atrial arrhythmias.
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