| Project/Area Number |
26461084
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
小笠原 邦昭 岩手医科大学, 医学部, 教授 (00305989)
中谷 敬明 岩手県立大学, 社会福祉学部, 准教授 (60438083)
吉岡 邦浩 岩手医科大学, 医学部, 教授 (70210648)
佐々木 真理 岩手医科大学, 医学部, 教授 (80205864)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 高次脳機能障害 / 心臓大血管手術 / 脳分子イメージング / 人工心肺 / 脳スペクト / 頭部MRA / 高次脳機能 / 術後高次脳機能障害 / 脳MRI |
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| Outline of Final Research Achievements |
We considered whether it was related to an appearance of postoperative cognitive dysfunction under the off-pump cardiovascular surgery or cardiopulmonary bypass surgery, hypothermia circulatory arrest surgery, during a slight brain damage on the nervous system. A decline of the transient cognition function was admitted in hypothermia circulatory arrest. The spread abnormality of brain damage wasn't admitted by fractional anisotropy (FA) value by diffusion tensor imaging of MRI, but broad transient spread abnormality has occurred to the cerebral white matter after cardiopulmonary bypass surgery by an analysis using the spread kurtosis picture: diffusion kurtosis imaging (DKI) detected in mean kurtosis (MK) .But the spread abnormality wasn't also admitted using DKI under the off-pump cardiovascular surgery
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