| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
As the in-vivo heart failure model, isoproterenol injection model was employed with dose of 80mg/kg/day for 2 days. Histological evaluation showed myocardial hypertrophy, degeneration and interstitial proliferation, and the electrophysiological evaluation found prolongation of effective refractory period (mean 52%) and MAP duration (120% MAP-20 and 56% MAP-90). Early step of inflammation was considered to play a role in these changes because increase of CTGF, TGF-beta, MCP-1, and IL-2 were found. By re-design of plasmid, transfection of Kv1.3 to the fibroblast was improved, but the reproducibility was still limited.
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