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Elucidation of the pathophysiology of acute heart failure and development of novel therapies based on clinical data and epigenetics

Research Project

Project/Area Number 26461086
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionKyorin University

Principal Investigator

MATSUSHITA Kenichi  杏林大学, 医学部, 講師 (10317133)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords循環器 / 心不全
Outline of Final Research Achievements

This research was performed based on a detailed database of patients with acute heart failure. Analysis by classification of left ventricular ejection fraction revealed significant differences in the utility of echocardiography indices and risk factors for acute worsening renal function. We also analyzed the clinical characteristics and specific prognostic factors for patients with acute heart failure with elevated blood pressure on admission, with clinically important findings reported. In addition, the epigenetics of obesity and metabolic syndrome as the potential underlying etiology of heart failure were summarized and reported. The epigenetics of cardiorenal syndrome associated with the pathophysiology and prognosis of acute heart failure were also summarized and reported.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (13 results)

All 2017 2016 2015 2014

All Journal Article (11 results) (of which Peer Reviewed: 10 results,  Acknowledgement Compliant: 9 results,  Open Access: 1 results) Presentation (2 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Differences in predictors of one-year mortality between patients with hypertensive and non-hypertensive acute heart failure: Usefulness of E/E' in hypertensive heart failure.2017

    • Author(s)
      Matsushita K, Minamishima T, Sakata K, Satoh T, Yoshino H.
    • Journal Title

      Eur J Intern Med

      Volume: 38 Pages: e13-e14

    • DOI

      10.1016/j.ejim.2016.10.018

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Mesenchymal stem cells in obesity: insights for translational applications.2017

    • Author(s)
      Matsushita K, Dzau VJ.
    • Journal Title

      Lab Invest

      Volume: 97 Issue: 10 Pages: 1158-1166

    • DOI

      10.1038/labinvest.2017.42

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Pathogenetic pathways of cardiorenal syndrome and their possible therapeutic implications.2016

    • Author(s)
      Matsushita K.
    • Journal Title

      Curr Pharm Des

      Volume: 22 Issue: 30 Pages: 4629-4637

    • DOI

      10.2174/1381612822666160510125057

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Mesenchymal stem cells and metabolic syndrome: current understanding and potential clinical implications.2016

    • Author(s)
      Matsushita K.
    • Journal Title

      Stem Cells Int

      Volume: 2016 Issue: 1 Pages: 2892840-2892840

    • DOI

      10.1155/2016/2892840

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Deletion of angiotensin II type 2 receptor accelerates adipogenesis in murine mesenchymal stem cells via Wnt10b/beta-catenin signaling.2016

    • Author(s)
      Matsushita K, Wu Y, Pratt RE, Dzau VJ.
    • Journal Title

      Lab Invest

      Volume: 96 Issue: 8 Pages: 909-917

    • DOI

      10.1038/labinvest.2016.66

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Nuclear hormone receptor LXRα inhibits adipocyte differentiation of mesenchymal stem cells with Wnt/beta-catenin signaling.2016

    • Author(s)
      Matsushita K, Morello F, Zhang Z, Masuda T, Iwanaga S, Steffensen KR, Gustafsson JA, Pratt RE, Dzau VJ
    • Journal Title

      Lab Invest

      Volume: 96 Issue: 2 Pages: 230-238

    • DOI

      10.1038/labinvest.2015.141

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Successful treatment of severe right-sided heart failure due to postoperative constrictive pericarditis with tolvaptan.2016

    • Author(s)
      Kanaya M, Matsushita K, Inami T, Yamasaki S, Mizumi S, Minamishima T, Goda A, Ueda A, Sakata K, Satoh T, Yoshino H.
    • Journal Title

      Am J Ther

      Volume: 23 Issue: 1 Pages: e264-e267

    • DOI

      10.1097/mjt.0000000000000146

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparison of the reliability of E/E' to estimate pulmonary capillary wedge pressure in heart failure patients with preserved ejection fraction versus those with reduced ejection fraction.2015

    • Author(s)
      Matsushita K, Minamishima T, Goda A, Ishiguro H, Kosho H, Sakata K, Satoh T, Yoshino H.
    • Journal Title

      Int J Cardiovasc Imaging

      Volume: 31 Issue: 8 Pages: 1497-1502

    • DOI

      10.1007/s10554-015-0718-7

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Comparison of risk factors for acute worsening renal function in heart failure patients with and without preserved ejection fraction.2015

    • Author(s)
      Yamagishi T, Matsushita K, Minamishima T, Goda A, Sakata K, Satoh T, Yoshino H.
    • Journal Title

      Eur J Intern Med

      Volume: 26 Issue: 8 Pages: 599-602

    • DOI

      10.1016/j.ejim.2015.08.003

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Blockade of angiotensin II type 2 receptor by PD123319 inhibits osteogenic differentiation of human mesenchymal stem cells via inhibition of extracellular signal-regulated kinase signaling.2015

    • Author(s)
      Matsushita K, Wu Y, Pratt RE, Dzau VJ.
    • Journal Title

      J Am Soc Hypertens

      Volume: 9 Issue: 7 Pages: 517-525

    • DOI

      10.1016/j.jash.2015.06.006

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 急性心不全2014

    • Author(s)
      松下健一
    • Journal Title

      杏林医学会雑誌

      Volume: 45 Pages: 165-169

    • NAID

      130004903276

    • Related Report
      2014 Research-status Report
  • [Presentation] Differences in predictors of one-year mortality between patients with hypertensive and non-hypertensive acute heart failure: Usefulness of E/E' in hypertensive heart failure.2016

    • Author(s)
      Matsushita K, Minamishima T, Sakata K, Satoh T, Yoshino H.
    • Organizer
      The 26th European Meeting on Hypertension and Cardiovascular Protection
    • Place of Presentation
      Paris (France)
    • Year and Date
      2016-06-10
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Differences between patients with diastolic heart failure and those with systolic heart failure in the way that hypertension is involved in acute worsening renal function2015

    • Author(s)
      Yamagishi T, Matsushita K, Minamishima T, Goda A, Sakata K, Satoh T, Yoshino H.
    • Organizer
      25th European Meeting on Hypertension and Cardiovascular Protection
    • Place of Presentation
      Milan (Italy)
    • Year and Date
      2015-06-12
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2014-04-04   Modified: 2018-03-22  

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