Elucidation of the pathophysiology of acute heart failure and development of novel therapies based on clinical data and epigenetics
Project/Area Number |
26461086
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Cardiovascular medicine
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Research Institution | Kyorin University |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 循環器 / 心不全 |
Outline of Final Research Achievements |
This research was performed based on a detailed database of patients with acute heart failure. Analysis by classification of left ventricular ejection fraction revealed significant differences in the utility of echocardiography indices and risk factors for acute worsening renal function. We also analyzed the clinical characteristics and specific prognostic factors for patients with acute heart failure with elevated blood pressure on admission, with clinically important findings reported. In addition, the epigenetics of obesity and metabolic syndrome as the potential underlying etiology of heart failure were summarized and reported. The epigenetics of cardiorenal syndrome associated with the pathophysiology and prognosis of acute heart failure were also summarized and reported.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Successful treatment of severe right-sided heart failure due to postoperative constrictive pericarditis with tolvaptan.2016
Author(s)
Kanaya M, Matsushita K, Inami T, Yamasaki S, Mizumi S, Minamishima T, Goda A, Ueda A, Sakata K, Satoh T, Yoshino H.
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Journal Title
Am J Ther
Volume: 23
Issue: 1
Pages: e264-e267
DOI
Related Report
Peer Reviewed
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