Therapeutic target in patients with heart failure complicated by chronic kidney disease

• Project/Area Number: 26461088
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Japan Research Promotion Society for Cardiovascular Diseases
• Principal Investigator: Yoshikawa Tsutomu 公益財団法人日本心臓血圧研究振興会(臨床研究施設・研究部門), 内科医局, 副院長・部長 (20174906)
• Co-Investigator(Kenkyū-buntansha): 香坂 俊 慶應義塾大学, 医学部(信濃町), 講師 (30528659)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 心不全 / 慢性腎臓病 / バイオマーカー / 長期予後 / 腎機能 / 利尿薬

Outline of Final Research Achievements

We enrolled patients with acute decompensated heart failure (ADHF) consecutively at 4 major teaching hospitals in western Tokyo area. We found that intravenous use of furosemide was associated with in-hospital clinical outcome but its significance was different by the baseline eGFR. In addition, plasma volume depletion induced by diuretic use was different between ADHF with preserved ejection fraction and ADHF with reduced ejection fraction. We finally examined the significance of baseline renal function on short-term and long-term clinical outcome in 1732 patients with ADHF. Worsening renal function (WRF) was more common in patients with lower eGFR group than higher group. WRF was an independent predictor of the in-hospital death, but did not predict the cardiac event after discharge. eGFR at admission was an independent predictor of all-cause mortality and rehospitalization for ADHF during the long-term follow-up by the Cox proportional hazard analysis.

Research Products

• [Journal Article] Predictive Value of QRS Duration at Admission for In-Hospital Clinical Outcome of Takotsubo Cardiomyopathy (2017)
  • Author(s): Yamaguchi T, Yoshikawa T, Isogai T, Miyamoto T, Maekawa Y, Ueda T, Sakata K, Murakami T, Yamamoto T, Nagao K, Takayama M
  • Journal Title: Circulation Journal Volume: 81 Issue: 1 Pages: 62-68
  • DOI: 10.1253/circj.CJ-16-0912
  • NAID: 130005252686
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Effect of Obesity on the Prognostic Impact of Atrial Fibrillation in Heart Failure With Preserved Ejection Fraction (2017)
  • Author(s): Yagawa M, Nagatomo Y, Izumi Y, Mahara K, Tomoike H, Shiraishi Y, Kohno T, Mizuno A, Goda A, Kohsaka S, Yoshikawa T
  • Journal Title: Circulation Journal Volume: 81 Issue: 7 Pages: 966-973
  • DOI: 10.1253/circj.CJ-16-1130
  • NAID: 130006887054
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Current use of guideline-based medical therapy in elderly patients admitted with acute heart failure with reduced ejection fraction and its impact on event-free survival. (2017)
  • Author(s): Akita K, Kohno T, Kohsaka S, Shiraishi Y, Nagatomo Y, Izumi Y, Goda A, Mizuno A, Sawano M, Inohara T, Fukuda K, Yoshikawa T
  • Journal Title: Int J Cardiol Volume: 235 Pages: 162-168
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Validation of the Get With The Guideline-Heart Failure risk score in Japanese patients and the potential improvement of its discrimination ability by the inclusion of B-type natriuretic peptide level. (2016)
  • Author(s): Shiraishi Y, Kohsaka S, Abe T, Mizuno A, Goda A, Izumi Y, Yagawa M, Akita K, Sawano M, Inohara T, Takei M, Takashi K, Higuchi S, Yamazoe M, Mahara K, Fukuda K, Yoshikawa T.
  • Journal Title: American Heart Journal Volume: 171 Issue: 1 Pages: 33-39
  • DOI: 10.1016/j.ahj.2015.10.008
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Extent of Late Gadolinium Enhancement on Cardiac Magnetic Resonance Imaging in Japanese Hypertrophic Cardiomyopathy Patients (2016)
  • Author(s): Hen Y, Iguchi N, Utanohara Y, Takada K, Machida H, Takara A, Teraoka K, Sumiyoshi T, Takamisawa I, Takayama M, Yoshikawa T
  • Journal Title: Circulation Journal Volume: 80 Issue: 4 Pages: 950-957
  • DOI: 10.1253/circj.CJ-15-1100
  • NAID: 130005139567
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Immunoadsorption therapy for dilated cardiomyopathy using tryptophan column-A prospective, multicenter, randomized, within-patient and parallel-group comparative study to evaluate efficacy and safety. (2016)
  • Author(s): Yoshikawa T, Baba A, Akaishi M, Wakabayashi Y, Monkawa T, Kitakaze M, Izumi T, Tomoike H.
  • Journal Title: J Clin Apher. Volume: 31 Issue: 6 Pages: 141-150
  • DOI: 10.1002/jca.21446
  • Peer Reviewed / Open Access
• [Journal Article] 心不全治療薬 (2016)
  • Author(s): 吉川勉
  • Journal Title: 医薬ジャーナル Volume: 52 Pages: 426-431
• [Journal Article] Early vs. Late Reverse Ventricular Remodeling in Patients with Cardiomyopathy. (2015)
  • Author(s): Banno A, Kohsaka S, Inohara T, Koide K, Shiraishi Y, Kohno T, Sano M, Yoshikawa T, Fukuda K
  • Journal Title: J Cardiol Volume: 68 Issue: 1 Pages: 57-63
  • DOI: 10.1016/j.jjcc.2015.07.021
  • Peer Reviewed
• [Journal Article] Enhanced Oxidative Stress is Associated with Sleep-Disordered Breathing and Obesity in Patients with Heart Failure. (2015)
  • Author(s): Kondo M, Kohno T, Kohsaka S, Fukuoka R, Shiraishi Y, Sawano M, Inohara T, Sano M, Yoshikawa T, Fukuda K
  • Journal Title: Int J Cardiol Volume: 209 Pages: 133-135
  • DOI: 10.1016/j.ijcard.2016.02.042
  • Peer Reviewed
• [Journal Article] Takotsubo cardiomyopathy, a new concept of cardiomyopathy: clinical feaures and pathophysiology. (2015)
  • Author(s): Yoshikawa T
  • Journal Title: Int J Cardiol Volume: 182 Pages: 297-303
  • DOI: 10.1016/j.ijcard.2014.12.116
  • Peer Reviewed
• [Journal Article] Rationale and design of the double-blind, randomized, placebo-controlled multicenter trial on efficacy of early initiation of eplerenone treatment in patients with acute heart failure (EARLIER). (2015)
  • Author(s): Asakura M, Yamamoto H, Asai K, Hanatani A, Hirata K, Hirayama A, Kimura K, Kobayashi Y, Momomura S, Nakagawa Y, Nishi Y, Saito Y, Satoh Y, Yamada T, Yamashina A, Yasuda S, Yoshikawa T, Kada A, Uesaka H, Kitakaze M, on behald of the EARLIER investigators and coordinators
  • Journal Title: Cardiovasc Drugs Ther Volume: ２５ Issue: 2 Pages: 179-185
  • DOI: 10.1007/s10557-014-6565-2
  • Peer Reviewed
• [Journal Article] Effect of estimated plasma volume reduction on renal function for acute heart failure differs between patients with preserved and reduced ejection fraction. (2015)
  • Author(s): Takei M, Shun Kohsaka S, Shiraishi Y, oda A, Izumi Y, Yagawa M, Mizuno A, Inohara T, Kohno T, Fukuda K, Yoshikawa T
  • Journal Title: Circ Heart Fail Volume: 8 Issue: 3 Pages: 527-532
  • DOI: 10.1161/circheartfailure.114.001734
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Application of the United States acute heart failure risk prediction model in Japanese patients; analysis from a contemporary multicenter registry. (2015)
  • Author(s): Makino J, Kohsaka S, Shiraishi Y, Inohara T, Goda A, Izumi Y, Yagawa M, Mizuno A, Fukuda K, Yoshikawa T
  • Journal Title: Int J Cardiol Volume: 195 Pages: 323-325
  • DOI: 10.1016/j.ijcard.2015.05.164
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] MRI and serum high-sensitivity C reactive protein predict long-term mortality in non-ischaemic cardiomyopathy. (2015)
  • Author(s): Sadahiro T, Kohsaka S, Okuda S, Inohara T, Shiraishi Y, Kohno T, Yoshikawa T, Fukuda K
  • Journal Title: Open Heart Volume: 2 Issue: 1 Pages: 33-39
  • DOI: 10.1136/openhrt-2015-000298
  • Peer Reviewed
• [Journal Article] Gender Differences in Patients with Takotsubo Cardiomyopathy: Multi-Center Registry from Tokyo CCU Network. (2015)
  • Author(s): Murakami T, Yoshikawa T, Maekawa Y, Ueda T, Isogai T, Sakata K, Nagao K, Yamamoto T, Takayama M
  • Journal Title: PLoS One Volume: 10 Issue: 8 Pages: e0136655-e0136655
  • DOI: 10.1371/journal.pone.0136655
  • NAID: 40020764954
  • Peer Reviewed / Open Access
• [Journal Article] 理学療法の立場から (2015)
  • Author(s): 安達裕一、斎藤正和、吉川勉
  • Journal Title: Medical Alliance Volume: 1 Pages: 350-355
• [Journal Article] β遮断薬と遺伝子多型 (2015)
  • Author(s): 吉川勉
  • Journal Title: Heart View Volume: 19 Pages: 34-39
• [Journal Article] Effect of estimated plasma volume reduction on renal function for acute heart failure differs between patients with preserved and reduced ejection fraction. (2015)
  • Author(s): Takei M, Shun Kohsaka S, Shiraishi Y, oda A, Izumi Y, Yagawa M, Mizuno A, Inohara T, Kohno T, Fukuda K, Yoshikawa T
  • Journal Title: Ｃｉｒｃ Ｈｅａｒｔ Ｆａｉｌ （ｉｎ ｐｒｅｓｓ） Volume: -
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Rationale and design of the double-blind, randomized, placebo-controlled multicenter trial on efficacy of early initiation of eplerenone treatment in patients with acute heart failure (EARLIER). (2015)
  • Author(s): Asakura M, Yamamoto H, Asai K, Hanatani A, Hirata K, Hirayama A, Kimura K, Kobayashi Y, Momomura S, Nakagawa Y, Nishi Y, Saito Y, Satoh Y, Yamada T, Yamashina A, Yasuda S, Yoshikawa T, Kada A, Uesaka H, Kitakaze M, on behald of the EARLIER investigators and coordinators
  • Journal Title: Cardiovasc Drugs Ther (online publication) Volume: -
  • Peer Reviewed
• [Journal Article] Presence of Autoantibody Directed against β1-Adrenergic Receptors is Associated with Amelioration of Cardiac Function in Response to Carvedilol: Japanese Chronic Heart Failure (J-CHF) Study. (2015)
  • Author(s): Nagatomo Y, Yoshikawa T, Okamoto H, Kitabatake A, Hori M
  • Journal Title: Ｊ Ｃａｒｄ Ｆａｉｌ Volume: 21 Issue: 3 Pages: 198-207
  • DOI: 10.1016/j.cardfail.2014.12.005
  • Peer Reviewed
• [Journal Article] Seasonal Changes in Systemic Volume Overload Are to Be Considered (2015)
  • Author(s): Mizuno A, Kohsaka S, Shiraishi Y, Goda A, Yoshikawa T
  • Journal Title: Circulation Journal Volume: 79 Issue: 3 Pages: 670
  • DOI: 10.1253/circj.CJ-14-1333
  • NAID: 130004927113
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic implication of physical signs of congestion in acute heart failure patients and its association with steady-state biomarker levels. (2014)
  • Author(s): Negi S, Sawano M, Kohsaka S, Inohara T, Shiraishi Y, Kohno T, Maekawa Y, Sano M, Yoshikawa T, Fukuda K
  • Journal Title: PLOS ONE Volume: 9
  • Peer Reviewed / Open Access
• [Journal Article] Characterization of predictors of in-hospital cardiac complications of takotsubo cardiomyopathy: multi-center registry from Tokyo CCU Network. (2014)
  • Author(s): Murakami T, Yoshikawa T, Maekawa Y, Ueda T, Isogai T, Konishi Y, Sakata K, Nagao K, Yamamoto T, Takayama M
  • Journal Title: J Cardiol Volume: 63 Pages: 269-273
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic impact of renal and hepatic dysfunction based on the MELD-XI score in patients with acute heart failure. (2014)
  • Author(s): 6.Inohara T, Kohsaka S, Shiraishi Y, Goda A, Sawano M, Yagawa M, Mahara K, Fukuda K, Yoshikawa T
  • Journal Title: Int J Cardiol Volume: 176 Pages: 571-573
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Presence of ventricular aneurysm predicts poor clinical outcomes in patients with cardiac sarcoidosis. (2014)
  • Author(s): 7.Miyazawa K, Yoshikawa T, Takamisawa I, Mahara K, Inoue K, Iguchi N, Takayama M, Umemura J, Tomoike H
  • Journal Title: Int J Cardiol Volume: 177 Pages: 720-722
  • Peer Reviewed / Open Access
• [Presentation] Impact of body mass index on ih-hospital prognosis in patients with Takotsubo cardiomyopathy: Multicenter cohort study (2017)
  • Author(s): Isogai T, Yoshikawa T, Ueda T, Maekawa Y, Sakata K, Yamaguchi T, Imori Y, Murakami T, Teraoka K, Mochizuki H, Nagao K, Yamamoto T, Takayama M
  • Organizer: 81th Japanese Circulation Society Meeting
  • Place of Presentation: Kanazawa
  • Year and Date: 2017-03-19
• [Presentation] Newly detected atrial fibrillation is associated with poor clinical outcome in heart failure with preserved ejection fraction (2017)
  • Author(s): Ieki H, Nagatomo Y, Nagai T, Sugano Y, Saito Y, Yoshikawa T, Anzai T
  • Organizer: 81th Japanese Circulation Society Meeting
  • Place of Presentation: Kanazawa
  • Year and Date: 2017-03-19
• [Presentation] Atrial fibrillation has a differential prognostic impact in obese vs. non-obese patients with heart failure with preserved ejection fraction (2017)
  • Author(s): Yoshikawa T, Nagatomo Y, Yagawa M, Izumi Y, Mahara K, Tomoike H, Shiraishi Y, Inohara T, Mizuno A, Goda A, Kohsaka S
  • Organizer: Late Breaking Cohort Studies 3 “Heart Failure: Its Clinical Background and Treatment”, 81th Japanese Circulation Society Meeting
  • Place of Presentation: Kanazawa
  • Year and Date: 2017-03-18
• [Presentation] Underweight is an independent predictor of outcomes in heart failure with preserved ejection fraction: A report from JASPER Study (2017)
  • Author(s): Matsumoto J, Kinugawa S, Fukushima A, Yokota T, Yoshikawa T, Saito Y, Nagai T, Anzai T
  • Organizer: Late Breaking Cohort Studies 3 “Heart Failure: Its Clinical Background and Treatment”, 81th Japanese Circulation Society Meeting
  • Place of Presentation: Kanazawa
  • Year and Date: 2017-03-18
• [Presentation] Monthly variations of incidence of Takotsubo cardiomyopathy in the Tokyo CCU Network Registry (2017)
  • Author(s): Murakami T, Yoshikawa T, Maekawa Y, Ueda T, Sakata K, Isogai T, Yamaguchi T, Mochizuki H, Imori Y, Teraoka K, Yamamoto T, Nagao K, Takayama M
  • Organizer: 81th Japanese Circulation Society Meeting
  • Place of Presentation: Kanazawa
  • Year and Date: 2017-03-18
• [Presentation] Additional change of renal function during hospitalization predicts adverse outcome in HFpEF with renal dysfunction (2017)
  • Author(s): Matsumoto Y, Nagatomo Y, Nagai T, Sugano Y, Saitou Y, Yoshikawa T, Anzai T
  • Organizer: 81th Japanese Circulation Society Meeting
  • Place of Presentation: Kanazawa
  • Year and Date: 2017-03-18
• [Presentation] Different contribution of modifiable patient characteristics to early and late adverse outcomes in patients with acute heart failure (2017)
  • Author(s): Kimura M, Kohno T, Kohsaka S, Shiraishi Y, Fukuoka R, Nagatomo Y, Yagawa M, Goda A, Mizuno A, Sujino Y, Fukuda K, Yoshikawa T
  • Organizer: 81th Japanese Circulation Society Meeting
  • Place of Presentation: Kanazawa
  • Year and Date: 2017-03-18
• [Presentation] Lower body mass index is a risk factor of blunted response to beta-blocker therapy using carvedilol: Insight from J-CHF Study (2017)
  • Author(s): Nagatomo Y, Yoshikawa T, Okamoto H, Kitabatake A, Hori M
  • Organizer: 81th Japanese Circulation Society Meeting
  • Place of Presentation: Kanazawa
  • Year and Date: 2017-03-18
• [Presentation] Relationship between elevated peripheral leukocyte counts and in-hospital outcomes in patients with Takotsubo cardiomyopathy (2017)
  • Author(s): Maekawa Y, Yoshikawa T, Ueda T, Sakata K, Isogai T, Yamaguchi T, Imori Y, Teraoka K, Murakami T, , Mochizuki H, Nagao K, Yamamoto T, Takayama M
  • Organizer: 81th Japanese Circulation Society Meeting
  • Place of Presentation: Kanazawa
  • Year and Date: 2017-03-18
• [Presentation] Anemia is associated with the blunted response to beta-blocker therapy using carvedilol: Insight from Japanese Chronic Heart failure (J-CHF) Study (2017)
  • Author(s): 長友祐司 吉川勉 岡本洋 堀正二
  • Organizer: Late Breaking Clinical Trials 2 “Advance in Prevention and Treatment of Heart Failure”, 81th Japanese Circulation Society Meeting
  • Place of Presentation: Kanazawa
  • Year and Date: 2017-03-17
• [Presentation] Signal intensity pattern on MW T2-weight imaging after PTSMA predicts wall thickness reduction in HOCM (2017)
  • Author(s): 高良綾子 辺泰樹 寺岡邦彦 井口信雄 町田治彦 薄井秀美 上田みどり 堀川良史 高見澤格 高山守正 吉川勉
  • Organizer: 81th Japanese Circulation Society Meeting
  • Place of Presentation: Kanazawa
  • Year and Date: 2017-03-17
• [Presentation] Validation of the Seattle Heart Failure Model in heart failure patients: A report from the West Tokyo Heart Failure Registry (2017)
  • Author(s): Shiraishi Y, Kohsaka S, Kohno T, Shoji S, Goda A, Higuchi S, Mizuno A, Sugino Y, Yagawa M, Nagatomo Y, Mahara K, Yoshikawa T
  • Organizer: 81th Japanese Circulation Society Meeting
  • Place of Presentation: Kanazawa
  • Year and Date: 2017-03-17
• [Presentation] Characterization of the patients who were admitted for acute decompensated heart failure by clinical scenario (2017)
  • Author(s): Komuro J, Nagatomo Y, Yagawa M, Mahara K, Goda A, Sujino Y, Mizuno A, Kohno T, Kohsaka S, Yoshikawa T
  • Organizer: 81th Japanese Circulation Society Meeting
  • Place of Presentation: Kanazawa
  • Year and Date: 2017-03-17
• [Presentation] Usefulness of psoas muscle area to predict clinical events in pateints with acute decompensated heart failure (2017)
  • Author(s): Funamizu T, Nagatomo Y, Saji M, Yagawa M, Mahara K, Tomoike H, Kohsaka S, Yoshikawa T
  • Organizer: 81th Japanese Circulation Society Meeting
  • Place of Presentation: Kanazawa
  • Year and Date: 2017-03-17
• [Presentation] 日本人急性心不全患者の予後予測におけるGWTG Risk Scoreの有用性 (2016)
  • Author(s): 白石泰之 香坂俊 合田あゆみ 水野篤 筋野容守 吉川勉
  • Organizer: 第30回日本冠疾患学会学術集会ハートチームシンポジウム「データベース関連の合同シンポジウム」
  • Place of Presentation: 東京
  • Year and Date: 2016-12-11
• [Presentation] The significance of serum phosphorus level at admission for acute decompensated heart failure (2016)
  • Author(s): Ieki H, Nagatomo Y, Yagawa M, Mahara K, Tomoike H, Kohsaka S, Yoshikawa T
  • Organizer: 20th Japanese Heart Failure Society Meeting
  • Place of Presentation: Sapporo
  • Year and Date: 2016-10-08
• [Presentation] 高齢者心不全の薬物治療 (2016)
  • Author(s): 吉川勉
  • Organizer: 第20回日本心不全学会 特別企画1「高齢者心不全患者の治療に関するステートメント」
  • Place of Presentation: 札幌
  • Year and Date: 2016-10-07
• [Presentation] 高齢者心不全におけるガイドライン推奨薬物治療の遵守率と心不全再入院との関連 (2016)
  • Author(s): 河野隆志 香坂俊 秋田敬太郎 白石泰之 長友祐司 合田あゆみ 水野篤 福田恵一 吉川勉
  • Organizer: 第20回日本心不全学会シンポジウム5「高齢者心不全の治療と限界」
  • Place of Presentation: 札幌
  • Year and Date: 2016-10-07
• [Presentation] Serum uric acid increase through the treatment of ADHF might predict adverse outcome in patients with chronic heart failure (2016)
  • Author(s): Yamamoto H, Nagatomo Y, Yagawa M, Mahara K, Tomoike H, Kohsaka S, Yoshikawa T
  • Organizer: 20th Japanese Heart Failure Society Meeting
  • Place of Presentation: Sapporo
  • Year and Date: 2016-10-07
• [Presentation] Effects of febuxostat on cardiorenal function in patients with heart failure and hyperuricemia (2016)
  • Author(s): Nagatomo Y, Fukamizu T, Izumi Y, Yagawa M, Mahara K, Hen Y, Ito H, Ueda M, Suzuki M, Yoshikawa T
  • Organizer: 3rd World Congress of Acute Heart Failure
  • Place of Presentation: Florence
  • Year and Date: 2016-05-22
  • Int'l Joint Research
• [Presentation] Differential prognostic impact of atrial fibrillation in non-obese vs. obese patients with heart failure with preserved ejection fraction (2016)
  • Author(s): Yagawa M, Nagatomo Y, Izumi Y, Mahara K, Shiraishi Y, Inohara T, Mizuno A, Goda A, Kohsaka S, Yoshikawa T
  • Organizer: 3rd World Congress of Acute Heart Failure
  • Place of Presentation: Florence
  • Year and Date: 2016-05-22
  • Int'l Joint Research
• [Presentation] Clinical Aspects of Re-hospitalized Heart Failure. A Single Center Experience with 542 Consecutive Patients Hospitalized with Acutely Decompensated Heart Failure. (2016)
  • Author(s): Yagawa Y, Makoto Suzuki M, Mahara K, Tomoike H, Shiraishi Y, Inohara T, Mizuno A, Goda A, Kohsaka S, Yoshikawa T
  • Organizer: 80th Japanese Circulation Society Meeting
  • Place of Presentation: Sendai
  • Year and Date: 2016-03-20
• [Presentation] Frequent Flyers for Acute Heart Failure: Their Outcome Compared to Patients with Single Admission or de novo Heart Failure. (2016)
  • Author(s): Akita K, Kohno T, Kohsaka S, Shiraishi Y, Yagawa Y, Higuchi S, Goda A, Mizuno A, Fukuda K, Yoshikawa T
  • Organizer: 80th Japanese Circulation Society Meeting
  • Place of Presentation: Sendai
  • Year and Date: 2016-03-19
• [Presentation] Length of Stay in Patients Hospitalized for Acute Heart Failure ―A Report from the West Tokyo Heart Failure (WET-HF) Registry―. (2016)
  • Author(s): Moriyama H, Kohno T, Kohsaka S, Shiraishi Y, Akita K, Yagawa Y, Higuchi S, Goda A, Mizuno A, Fukuda K, Yoshikawa T
  • Organizer: 80th Japanese Circulation Society Meeting
  • Place of Presentation: Sendai
  • Year and Date: 2016-03-19
• [Presentation] International Comparison of Hospitalized Patients with Heart Failure with Preserved Ejection Fraction Based on Nationwide Registry-JASPER Study. (2016)
  • Author(s): Anzai T, Nagai T, Sugano Y, Takashio S, Takahama H, Ohhara T, Kanzaki H, Noguchi T, Kusano K, Yasuda S, Saito Y, Yoshikawa T, Ogawa H
  • Organizer: 80th Japanese Circulation Society Meeting
  • Place of Presentation: Sendai
  • Year and Date: 2016-03-18
• [Presentation] Excess Plasma Volume Reduction with Diuretics More Easily Cause Worsening of Renal Function in Patients with HFPEF. (2016)
  • Author(s): Takei M, Kohsaka S, Goda A, Mizuno A, Yoshikawa T
  • Organizer: 80th Japanese Circulation Society Meeting
  • Place of Presentation: Sendai
  • Year and Date: 2016-03-18
• [Presentation] 心不全患者に対する支援活動が臨床転帰に及ぼす影響について (2015)
  • Author(s): 中山恵津子 寒川和美 辻孝子 角口亜希子 三浦稚郁子 堀健太郎 矢川真弓子 友池仁暢 吉川勉
  • Organizer: 第19回日本心不全学会
  • Place of Presentation: 大阪
  • Year and Date: 2015-10-23
• [Presentation] 急性心不全患者の短期予後予測モデルの検討：West Tokyo Heart Failure (WET-HF) Registryからの報告 (2015)
  • Author(s): 白石泰之 香坂俊 合田あゆみ 樋口聡 泉祐樹 矢川真弓子 馬原啓太郎 山添正博 水野篤 池村修寛 秋田敬太郎 澤野充明 河野隆志 福田恵一 吉川勉
  • Organizer: 第63回日本心臓病学会
  • Place of Presentation: 横浜
  • Year and Date: 2015-09-18
• [Presentation] Incidence and long-term impact of progressive hyponatremia in heart failure patients with reduced and preserved ejection fraction. (2015)
  • Author(s): Yamazoe M, Mizuno A, Kohsaka S, Shiraishi Y, Inohara T, Goda A, Izumi Y, Yagawa M, Mahara K, Yoshikawa T
  • Organizer: European Society of Cardiology
  • Place of Presentation: London
  • Year and Date: 2015-08-30
  • Int'l Joint Research
• [Presentation] Patient characteristics and outcomes in Japanese and British patients admitted with heart failure; the West Tokyo - Kingston-upon-Hull collaboration. (2015)
  • Author(s): ShiraishiY, Dicken B, Kohsaka S, Rigby A, Rasool R, Inohara T, Goda A, Nagai T, Yoshikawa T, Cleland JGF
  • Organizer: Euro Heart Failure
  • Place of Presentation: Ａｔｈｅｎｓ(GREECE)
  • Year and Date: 2015-05-19
• [Presentation] Differences in guideline-based medical therapy of patients with heart failure in Japan and Great Britain. (2015)
  • Author(s): Shiraishi Y, Dicken B, Kohsaka S, Rigby A, Koshy A, Inohara T, Goda A, Nagai T, Yoshikawa T, Cleland JGF
  • Organizer: Euro Heart Failure
  • Place of Presentation: Ａｔｈｅｎｓ（GREECE)
  • Year and Date: 2015-05-18
• [Presentation] Prognostic impact of the presence of atrial fibrillation in ADHF patients with preserved EF: West Tokyo Heart Failure Registry (WET-HF). (2015)
  • Author(s): Yagawa M, Izumi Y, Mahara K, Shiraishi Y, Inohara T, Goda A, Kohsaka S, Yoshikawa T
  • Organizer: 79th Japanese Circulation Society Meeting
  • Place of Presentation: Osaka
  • Year and Date: 2015-04-26
• [Presentation] Pathophysiology of heart failure with preserved ejection fraction from the point of view of nationwide registry-JASPER study. (2015)
  • Author(s): Anzai T, Nagai T, Sugano Y, Ohara T, Kanzaki H, Noguchi T, Kusano K, Yasuda S, Saito Y, Yoshikawa T, Ogawa H
  • Organizer: 79th Japanese Circulation Society Meeting
  • Place of Presentation: Osaka
  • Year and Date: 2015-04-26
• [Presentation] Patient characteristics and outcome in Japanese and British patients admitted for acute heart failure: aa prospective international cohort study. (2015)
  • Author(s): Shiraishi Y, Benjamin D, Kohsaka S, Goda A, Izumi Y, Sawano M, Inohara T, Kohno T, Tagawa M, Mahara K, Fukuda K, Yoshikawa T, Cleland JGF
  • Organizer: 79th Japanese Circulation Society Meeting
  • Place of Presentation: Osaka
  • Year and Date: 2015-04-25
• [Presentation] Impaired renal function on admission does not presdict short-term, but predicts ,long-term clinical outcomes in acutely decompensated heart failure patients. (2015)
  • Author(s): Izumi Y, Yagawa M, Mahara K, Tomoike H, Shiraishi Y, Inohara T, Goda A, Yamazoe M, Mizuno A, Kohsaka S, Yoshikawa T
  • Organizer: 79th Japanese Circulation Society Meeting
  • Place of Presentation: Osaka
  • Year and Date: 2015-04-25
• [Presentation] Difference in the impact of progressive hyponatremia on long-term mortality in heart failure patients with reduced and preserved ejection fraction. (2015)
  • Author(s): Yamazoe M, Mizuno A, Kohsa S, Inohara T, Sawano M, Kohno T, Goda A, Izumi Y, Yagawa M, Mahara K, Yoshikawa T
  • Organizer: 79th Japanese Circulation Society Meeting
  • Place of Presentation: Osaka
  • Year and Date: 2015-04-25
• [Presentation] The implication and mid-term impact of guideline-based medical therapy in elderly population admitted with heart failure. (2015)
  • Author(s): Akita K, Kohno T, Kohsaka S, Shiraishi Y, Izumi Y, Goda A, Mizuno A, Sawano M, Inohara T, Fukuda K, Yoshikawa T
  • Organizer: 79th Japanese Circulation Society Meeting
  • Place of Presentation: Osaka
  • Year and Date: 2015-04-24
• [Presentation] Autoantibody titer directed against b1-adrenergic receptors is a predictor of reverse remodeling during carvedilol therapy for chronic heart failure: Japanese Chronic Heart Failure (J-CHF) Study. (2014)
  • Author(s): Nagatomo Y, Yoshikawa T, Okamoto H, Kitabatake A, Hori M
  • Organizer: American Heart Association Meeting
  • Place of Presentation: Ｃｈｉｃａｇｏ(USA)
  • Year and Date: 2014-11-19
• [Presentation] 拡張型心筋症に対する免疫吸着療法 (2014)
  • Author(s): 吉川勉
  • Organizer: 第18回日本心不全学会 シンポジウム「重症心不全の診断および治療戦略」
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2014-10-11
  • Invited
• [Presentation] Clinical scenarios on admission predict different clinical outcomes in relation to renal function in patients with acutely decompensated heart failure. (2014)
  • Author(s): Izumi Y, Yagawa M, Mahara K, Tomoike H, Shiraishi Y, Inohara T, Goda A, Kohasaka S, Yoshikawa T
  • Organizer: 18th Japanese Heart Failure Society Meeting
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2014-10-11
• [Presentation] Clinical features and outcome in octagenarians hospitalized for acute heart failure. (2014)
  • Author(s): Akita K, Kohno T, Kohsaka S, Shiraishi Y, Sawano M, Inhohara T, Maekawa Y, Sano M, Yoshikawa T, Fukuda K
  • Organizer: 18th Japanese Heart Failure Society Meeting
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2014-10-10
• [Presentation] 急性非代償性心不全における急性期フロセミド静注が腎機能悪化および短期予後に及ぼす影響 (2014)
  • Author(s): 泉祐樹 矢川真弓子 馬原啓太郎 友池仁暢 白石泰之 猪原拓 合田あゆみ 香坂俊 吉川勉
  • Organizer: 第62回日本心臓病学会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2014-09-28
• [Presentation] 心不全を契機に診断されたアミロイドーシス患者における予後予測因子の検討 (2014)
  • Author(s): 田嶋美裕 泉祐樹 矢川真弓子 高見澤格 井口信雄 高山守正 梅村純 住吉徹哉 友池仁暢 吉川勉
  • Organizer: 第62回日本心臓病学会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2014-09-27
• [Presentation] 急性非代償性心不全患者の短期予後予測リスクツリー作成の試み (2014)
  • Author(s): 牧野潤 白石泰之 香坂俊 合田あゆみ 猪原拓 矢川真弓子 福田恵一 吉川勉
  • Organizer: 第62回日本心臓病学会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2014-09-27
• [Presentation] たこつぼ型心筋症における院内心合併症予測因子の検討 (2014)
  • Author(s): 村上力 吉川勉 前川裕一郎 上田哲郎 磯貝俊明 小西裕二 坂田好美 山本剛 長尾健 高山守正
  • Organizer: 第62回日本心臓病学会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2014-09-27
• [Presentation] Patient characteristics and outcomes in Japanese and British patients admitted with heart failure; West Tokyo – Kingston upon Hull collaboration. (2014)
  • Author(s): Dicken B, Shiraishi Y, Kohsaka S, Rigby A, Inohara T, Goda A, Nagai T, Yoshikawa T, Cleland JGF
  • Organizer: European Scoeity of Cardiology Congress
  • Place of Presentation: Ｂａｒｃｅｌｏｎａ(SPAIN)
  • Year and Date: 2014-09-01