| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
We enrolled patients with acute decompensated heart failure (ADHF) consecutively at 4 major teaching hospitals in western Tokyo area. We found that intravenous use of furosemide was associated with in-hospital clinical outcome but its significance was different by the baseline eGFR. In addition, plasma volume depletion induced by diuretic use was different between ADHF with preserved ejection fraction and ADHF with reduced ejection fraction. We finally examined the significance of baseline renal function on short-term and long-term clinical outcome in 1732 patients with ADHF. Worsening renal function (WRF) was more common in patients with lower eGFR group than higher group. WRF was an independent predictor of the in-hospital death, but did not predict the cardiac event after discharge. eGFR at admission was an independent predictor of all-cause mortality and rehospitalization for ADHF during the long-term follow-up by the Cox proportional hazard analysis.
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