The role of dysautonomia and ADR in Takotsubo Cardiomyopathy

• Project/Area Number: 26461092
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: Sato Kyoko 東京女子医科大学, 医学部, 講師 (80335942)
• Co-Investigator(Kenkyū-buntansha): 小見山 智義 東海大学, 医学部, 准教授 (60439685)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: たこつぼ心筋症 / ストレス / 自律神経 / カテコラミン受容体 / カテコラミン / アドレナリン受容体 / 心交感神経終末分布

Outline of Final Research Achievements

Takotsubo Cardiomyopathy (TCM) is a disease typically characterized by transient left ventricular dysfunction with apical balooning. The clinical presentation is often similar to those of an acute myocardial infarction. Although the cause of TCM remains unknown, the emotional and physical stress and exaggerated sympathetic nerve activity plays a key role.
We studied mental stress response of autonomic nervous functions in 17 TCM patients (11 female) and 5 healthy subjects (4 female). TCM patients had greater systolic blood pressure decline than healthy subjects after the hyperventilation test. Valsalva ratio and sinus arrhythmia ratio of TCM patients were comparable to those of the healthy subjects. Plasma noradrenaline increment of TCM patients was higher than the healthy subjects after mental stress tests. Catecholamine receptor gene variants were found in 5 TCM patients. Further evaluation of the genotypes combined with clinical presentation is currently proceeding.

Research Products

• [Presentation] たこつぼ心筋症における自律神経異常とカテコラミン受容体遺伝子変異 (2016)
  • Author(s): 佐藤恭子, 中岡隆志, 小見山智義, 小林広幸, 佐倉 宏
  • Organizer: 第69回日本自律神経学会総会
  • Place of Presentation: 熊本県民交流館パレアホール
  • Year and Date: 2016-11-10