| Project/Area Number |
26461093
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Tsurumi University |
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Principal Investigator |
Ando Eriko 鶴見大学, 歯学部, 助教 (30410046)
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| Co-Investigator(Kenkyū-buntansha) |
小川 匠 鶴見大学, 歯学部, 教授 (20267537)
重田 優子 鶴見大学, 歯学部, 講師 (40367298)
石川 千恵子 鶴見大学, 歯学部, 臨床教授 (70176163)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 睡眠時無呼吸症候群 / 靭帯石灰化 / レプチン / 肥満 / 項靭帯石灰化 / いびき / 頚椎骨棘形成 / 高カルシウム血症 / 側方頭部X線規格写真 / 項靱帯石灰化 / アテローム性動脈硬化 / 睡眠時無呼吸症候群（OSA） / 頸椎骨棘形成 / アテローム性動脈硬化症 / 側方頭部Ｘ線規格写真 |
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| Outline of Final Research Achievements |
Last year we investigated the characteristics of sleep apnea in patients from the results of their blood tests. The blood tests were performed on 39 patients (Male:25, Female:14) with sleep apnea syndrome (SAS) who were diagnosed using full-night polysomnography.
There were no morbid findings in mineral metabolism or levels of Alkaline phosphatase. These results correspond to previous studies regarding the calcification of ligaments. In a previous study, it had been reported that Leptin may be related with ligament osteosis. The level of Leptin in the male SAS patients ranged from 2.0 to 26.8 ng/ml, and from 3.8 to 34.8 ng/ml in the female SAS patients. In nine (Male:5, Female:4) of the 39 patients, the level of Leptin indicated an abnormal value, over 13.0 ng/ml in the males, and over 21.8 ng/ml in the females. In addition, there were significant positive correlations between the level of Leptin and obesity (Body mass index: BMI), and SAS severity (Apnea-hypoapnea index: AHI).
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