| Project/Area Number |
26461098
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
Sugano Yasuo 国立研究開発法人国立循環器病研究センター, 病院, 医長 (00317124)
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| Co-Investigator(Kenkyū-buntansha) |
安斉 俊久 北海道大学, 医学研究院, 教授 (60232089)
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| Co-Investigator(Renkei-kenkyūsha) |
OUGOU Keiko 国立研究開発法人国立循環器病研究センター, 病院, 医師 (30601827)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 拡張型心筋症 / 心不全 / 炎症 / 線維化 / リモデリング / 免疫応答 / 細胞外マトリックス蛋白 / テネイシンＣ / マクロファージ / 左室リモデリング / 免疫細胞 / 樹状細胞 / 心臓リモデリング / テネイシンC |
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| Outline of Final Research Achievements |
Biopsy samples from 182 DCM patients were immunohistochemically stained with antibodies to infiltrating cells. Median numbers of myocardial CD3, CD68 and CD163-cell infiltrates were 8.1/mm2, 22.3/mm2, 6.5/mm2, respectively. Patients with higher counts of infiltrating CD3-, CD68- and CD163-positive cells had significantly poorer outcomes (p=0.007, p=0.011 and p=0.022, respectively). A high CD163-positive infiltrate count was independently associated with worse outcome in multivariate Cox regression analysis (hazard ratio=1.77, p=0.004), and multivariate linear regression analysis revealed that the CD163 cell count was an independent determinant of CAF (p<0.001).
DCM with increased myocardial immune activation was associated with poor long-term outcome. The association between M2 macrophages and collagen formation suggests the phenotypic polarisation of macrophages toward M2 may be associated with ventricular remodeling in DCM.
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