Development of a novel therapy for peripartum cardiomyopathy using natriuretic peptides
| Project/Area Number |
26461100
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
OTANI KENTARO 国立研究開発法人国立循環器病研究センター, 研究所, 上級研究員 (50470191)
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| Co-Investigator(Kenkyū-buntansha) |
徳留 健 国立研究開発法人国立循環器病研究センター, 研究所, 室長 (00443474)
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| Research Collaborator |
KAMIYA CHIZUKO 国立研究開発法人国立循環器病研究センター, 医師 (10551301)
NISHIMURA HIROHITO 国立研究開発法人国立循環器病研究センター研究所, 流動研究員 (30739735)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 周産期心筋症 / ナトリウム利尿ペプチド / 授乳 / 心肥大 |
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| Outline of Final Research Achievements |
In recent work, we demonstrated that mice lacking guanylyl cyclase-A (GC-A-KO), a receptor for atrial and brain natriuretic peptides, show severe postpartum cardiac hypertrophy. Interestingly, the postpartum cardiac hypertrophy in GC-A-KO was induced during lactation. The aim was to investigate the mechanisms underlying the lactation-induced cardiac hypertrophy in GC-A-KO. Additionally, we examined the single-nucleotide polymorphisms of natriuretic peptide-related genes in patients with peripatrum cardiomyopathy (PPCM). Plasma aldosterone level was significantly elevated in lactating GC-A-KO. Furthermore, the administration of a specific mineralocorticoid receptor blocker during lactation significantly suppressed the cardiac hypertrophy in GC-A-KO. Therefore, aldosterone would be a cause of lactation-induced cardiac hypertrophy in GC-A-KO. In addition, genotype distribution of natriuretic peptide clearance receptor gene differed markedly between women with PPCM and their controls.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Importance of endogenous atrial and brain natriuretic peptides in murine embryonic vascular and organ development.2016
Author(s)
Tokudome T, Kishimoto I, Shindo T, Kawakami H, Koyama T, Otani K, Nishimura H, Miyazato M, Kohno M, Nakao K, Kangawa K.
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Journal Title
Endocrinology
Volume: 157
Issue: 1
Pages: 358-367
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Atrial natriuretic peptide prevents cancer metastasis through vascular endothelial cells.2015
Author(s)
Nojiri T, Hosoda H, Tokudome T, Miura K, Ishikane S, Otani K, Kishimoto I, Shintani Y, Inoue M, Kimura T, Sawabata N, Minami M, Nakagiri T, Funaki S, Takeuchi Y, Maeda H, Kidoya H, Kiyonari H, Shioi G, Arai Y, Hasegawa T, Takakura N, Hori M, Ohno Y, Miyazato M, Mochizuki N, Okumura M, Kangawa K
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Journal Title
Proc Natl Acad Sci USA
Volume: 112
Issue: 13
Pages: 4086-4091
DOI
Related Report
Peer Reviewed / Open Access
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