Multicenter study of intra-coronary angioscopy after stent

• Project/Area Number: 26461101
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Hyogo Medical University
• Principal Investigator: Ishihara Masaharu 兵庫医科大学, 医学部, 教授 (00574683)
• Co-Investigator(Kenkyū-buntansha): 小川 久雄 国立研究開発法人国立循環器病研究センター, 病院, 理事長 (50177135)
• Research Collaborator: MATSHUOKA Hiroshi 愛媛県立今治病院, 副院長 ; WATANABE Kouki 済生会松山病院, 副院長 ; SATO Tetsuya 岡山赤十字病院, 部長 ; DAI Kazuoki 広島市立広島市民病院, 副部長
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 臨床心臓病 / 血管内視鏡 / 冠動脈ステント / 臨床心臓学

Outline of Final Research Achievements

We constructed comprehensive grading system for multicenter evaluation of neointimal coverage (NC) and plaque yellow color (YC) after stent. A total of 264 stents were observed by coronary angioscopy 1 year after PCI. Although the Max-NC grade was similar, the Min-NC grade was significantly higher and heterogeneity index was lower for 2nd-generation DES than for 1st-generation, and similar to BMS. DES. Both the YC grade and the incidence of thrombus with 1st-generation DES were lower than with 2nd-generation DES and BMS. These findings suggest favorable healing process after 2nd-generation DES that is comparable to BMS.

Research Products

• [Journal Article] Comparison of Chronic Angioscopic Findings of Bare Metal Stents, 1st-Generation Drug-Eluting Stents and 2nd-Generation Drug-Eluting Stents – Multicenter Study of Intra-Coronary Angioscopy After Stent (MICASA) – (2016)
  • Author(s): Dai K, Matsuoka H, Kawakami H, Sato T, Watanabe K, Nakama Y, Ishihara M
  • Journal Title: Circulation Journal Volume: 80 Issue: 9 Pages: 1916-1921
  • DOI: 10.1253/circj.CJ-16-0121
  • NAID: 130005406846
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] In-stent Neoatherosclerosis 10 Years after Bare Metal Stent Implantation Observed by Coronary Angioscopy (2015)
  • Author(s): Dai K, Ishihara m, Yamaji T, Oono M, Morita Y, Hashimoto H, Harima A, Ooi K, Oka T, Nakama Y, Sairaku A, Nishioka K, Miura F, Shimatani Y, Inoue I.
  • Journal Title: Angioscopy Volume: 1 Issue: 1 Pages: 32-34
  • DOI: 10.15791/angioscopy.cr.15.0003
  • NAID: 130005069292
  • ISSN: 2188-6571, 2188-7500
  • Peer Reviewed
• [Presentation] Differences in chronic angioscopic findings with different stent types in patients with and without diabetes mellitus: Sub-analysis of MICASA (2017)
  • Author(s): Tsushima R, Sato T, Dai K, Nakama Y, Watanabe K, Kawakami H, Matsuoka H, Ishihara M
  • Organizer: 日本循環器学会学術集会
  • Place of Presentation: 石川県立音楽堂(石川県,金沢市)
  • Year and Date: 2017-03-17
• [Presentation] Differences in chronic angioscopic findings with different stent types in patients with and without diabetes mellitus: Sub-analysis of MICASA (2017)
  • Author(s): Sato T, Dai K, Nakama Y, Watanabe K, Kawakami H, Matsuoka H, Ishihara M
  • Organizer: American College of Cardiology
  • Place of Presentation: Washington, USA
  • Year and Date: 2017-03-17
  • Int'l Joint Research
• [Presentation] Comparison of chronic angioscopic findings of BMS, 1st-generation DES and 2nd-generation DES: A report from Japanese multicenter registry (MICASA) (2016)
  • Author(s): Dai K, Matsuoka H, Kawakami H, Sato T, Watanabe K, Nakama Y, Ishihara M
  • Organizer: American College of Cardiology
  • Place of Presentation: Chicago, USA
  • Year and Date: 2016-04-02
  • Int'l Joint Research
• [Presentation] Comparison of Chronic Angioscopic Findings of BMS, 1st-Generation DES and 2nd-Generation DES:A Report From Japanese Multicenter Registry(MICASA) (2016)
  • Author(s): Dai K, Matsuoka H, Kawakami H, Sato T, Watanabe K, Nakama Y, Ishihara M
  • Organizer: American College of Cardiology 2016
  • Place of Presentation: Chicago, USA
  • Year and Date: 2016-04-02
  • Int'l Joint Research
• [Presentation] Comparison of Chronic Angioscopic Findings of BMS, 1st-Generation DES and 2nd-Generation DES:A Report from Japanese Multicenter Registry(MICASA) (2016)
  • Author(s): Dai K, Matsuoka H, Kawakami H, Sato T, Watanabe K, Nakama Y, Ishihara M
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台, 宮城
  • Year and Date: 2016-03-18