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Association between Vascular Function and Central Nervous System

Research Project

Project/Area Number 26461103
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionThe University of Tokyo

Principal Investigator

Amiya Eisuke  東京大学, 医学部附属病院, 助教 (80529090)

Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords血管機能 / 日常活動度 / 脳神経システム / 心臓リハビリテーション / 精神状態 / 血管内皮機能 / 認知機能 / 炎症
Outline of Final Research Achievements

In this research program, we explored new method of evaluating vascular function and we found that the frequency analysis of oscillatory vascular movement was useful for the intricate evaluation for vascular function. In addition, we found the behavior of arterial pulsation might also present the risk of cardiovascular disease.
We demonstrated the interrelationship between physical activity, vascular dysfunction exemplified by these evaluations and mental status, particularly in the clinical setting of cardiac rehabilitation.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (39 results)

All 2018 2017 2016 2015 2014

All Journal Article (20 results) (of which Peer Reviewed: 16 results,  Open Access: 8 results,  Acknowledgement Compliant: 1 results) Presentation (19 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] High-intensity aerobic interval training can lead to improvement in skeletal muscle power among in-hospital patients with advanced heart failure.2018

    • Author(s)
      Taya M, Amiya E, Hatano M, Maki H, Nitta D, Saito A, Tsuji M, Hosoya Y, Minatsuki S, Nakayama A, Fujiwara T, Konishi Y, Yokota K, Watanabe M, Morita H, Haga N, Komuro I.
    • Journal Title

      Heart Vessels

      Volume: - Issue: 7 Pages: 752-759

    • DOI

      10.1007/s00380-018-1120-x

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Is Exercise Training Appropriate for Patients With Advanced Heart Failure Receiving Continuous Inotropic Infusion? A Review.2018

    • Author(s)
      Amiya E, Taya M.
    • Journal Title

      Clin Med Insights Cardiol

      Volume: Jan 3 Pages: 12-12

    • DOI

      10.1177/1179546817751438

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An exploratory study on the efficacy and safety of a BCAA preparation used in combination with cardiac rehabilitation for patients with chronic heart failure.2017

    • Author(s)
      Takata M, Amiya E, Watanabe M, Hosoya Y, Nakayama A, Fujiwara T, Taya M, Oguri G, Hyodo K, Takayama N, Takano N, Mashiko T, Uemura Y, Komuro I.
    • Journal Title

      BMC Cardiovasc Disord.

      Volume: 17 Issue: 1 Pages: 205-205

    • DOI

      10.1186/s12872-017-0639-6

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phenotypic differences in aortic stenosis according to calcification grade.2016

    • Author(s)
      Takata M, Amiya E, Watanabe M, Shintani Y, Sakuma K, Saito A, Fukayama M, Ono M, Komuro I
    • Journal Title

      International journal of cardiology

      Volume: 216 Pages: 118-120

    • DOI

      10.1016/j.ijcard.2016.04.137

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Enhancement of arterial pulsation during flow-mediated dilation is impaired in the presence of ischemic heart disease.2016

    • Author(s)
      Amiya E, Watanabe M, Watanabe S, Takata M, Komuro I.
    • Journal Title

      Springerplus.

      Volume: 5(1) Issue: 1 Pages: 1103-1110

    • DOI

      10.1186/s40064-016-2794-0

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Different Contributions of Physical Activity on Arterial Stiffness between Diabetics and Non-Diabetics.2016

    • Author(s)
      Iwasa T, Amiya E, Ando J, Watanabe M, Murasawa T, Komuro I
    • Journal Title

      PLoS One.

      Volume: 11 Issue: 8 Pages: e0160632-e0160632

    • DOI

      10.1371/journal.pone.0160632

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fukutin gene mutations that cause left ventricular noncompaction2016

    • Author(s)
      Amiya E, Morita H, Hatano M, Nitta D, Hosoya Y, Maki H, Motozawa Y, Sato N, Ishiura H, Numakura S, Shintani Y, Kinugawa K, Takeda N, Shimizu J, Tsuji S, Komuro I.
    • Journal Title

      International Journal of Cardiology

      Volume: 222 Pages: 727

    • DOI

      10.1016/j.ijcard.2016.08.011

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Interaction of hyperlipidemia and reactive oxygen species: Insights from the lipid-raft platform2016

    • Author(s)
      Amiya E
    • Journal Title

      World J Cardiol.

      Volume: 8 Issue: 12 Pages: 689-694

    • DOI

      10.4330/wjc.v8.i12.689

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The association between orthostatic increase in pulse pressure and ischemic heart disease.2016

    • Author(s)
      Takata M, Amiya E, Watanabe M, Yamada N, Watanabe A, Kawarasaki S, Ozeki A, Nakao T, Hosoya Y, Ando J, Komuro I.
    • Journal Title

      Clin Exp Hypertens.

      Volume: 38 Issue: 1 Pages: 23-29

    • DOI

      10.3109/10641963.2015.1047948

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Physical Activity2015

    • Author(s)
      Amiya E, Taya M, Watanabe M
    • Journal Title

      International Heart Journal

      Volume: 56 Issue: 6 Pages: 583-584

    • DOI

      10.1536/ihj.15-301

    • NAID

      130005113063

    • ISSN
      1349-2365, 1349-3299
    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Improvement of Severe Heart Failure after Endovascular Stent Grafting for Thoracic Aortic Aneurysm.2015

    • Author(s)
      Yamaguchi T, Amiya E, Watanabe M, Komuro I.
    • Journal Title

      Int Heart J

      Volume: 56 Pages: 682-685

    • NAID

      130005113054

    • Related Report
      2015 Research-status Report
  • [Journal Article] 心不全に合併するカヘキシア・サルコペニアに対するアプローチ2015

    • Author(s)
      網谷英介
    • Journal Title

      診断と治療

      Volume: 103 Pages: 390-394

    • Related Report
      2015 Research-status Report
  • [Journal Article] Brachial artery diameter has a predictive value in the improvement of flow-mediated dilation after aortic valve replacement for aortic stenosis2015

    • Author(s)
      Takata M, Amiya E, Watanabe M, Ozeki A, Watanabe A, Kawarasaki S, Nakao T, Hosoya Y, Uno K, Saito A, Murasawa T, Ono M, Nagai R, Komuro I. Brachial artery diameter has a predictive value in the improvement of flow-mediated dilation after aortic valve replacement for aortic stenosis.
    • Journal Title

      Heart Vessels

      Volume: 30 Issue: 2 Pages: 218-26

    • DOI

      10.1007/s00380-014-0475-x

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] 心不全のすべて 「心不全に合併するカヘキシア・サルコペニアに対するアプローチ2015

    • Author(s)
      網谷英介
    • Journal Title

      診断と治療

      Volume: 103 Pages: 390-94

    • Related Report
      2014 Research-status Report
  • [Journal Article] Diurnal body temperature rise is reduced in diabetes with autonomic neuropathy2014

    • Author(s)
      Amiya E, Watanabe M, Takata M, Nakao T, Hosoya Y, Watanabe S, Nagai R, Komuro I.
    • Journal Title

      Clin Auton Res

      Volume: 24 Issue: 2 Pages: 95-7

    • DOI

      10.1007/s10286-013-0223-9

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] The Relationship between Vascular Function and the Autonomic Nervous System2014

    • Author(s)
      Amiya E, Watanabe M, Komuro I
    • Journal Title

      Annals of Vascular Diseases

      Volume: 7 Issue: 2 Pages: 109-119

    • DOI

      10.3400/avd.ra.14-00048

    • NAID

      130004488048

    • ISSN
      1881-641X, 1881-6428
    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of add-on aliskiren to type 1 angiotensin receptor blocker therapy on endothelial function and autonomic nervous system in hypertensive patients with ischemic heart disease.2014

    • Author(s)
      Ozeki A, Amiya E, Watanabe M, Hosoya Y, Takata M, Watanabe A, Kawarasaki S, Nakao T, Watanabe S, Omori K, Yamada N, Tahara Y, Hirata Y, Nagai R
    • Journal Title

      J Clin Hypertens

      Volume: 16 Issue: 8 Pages: 591-8

    • DOI

      10.1111/jch.12366

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Elevated C-reactive protein levels and enhanced high frequency vasomotion in patients with ischemic heart disease during brachial flow-mediated dilation2014

    • Author(s)
      Watanabe S, Amiya E, Watanabe M, Takata M, Ozeki A, Watanabe A, Kawarasaki S, Nakao T, Hosoya Y, Nagata K, Nagai R, Komuro I.
    • Journal Title

      PLoS One

      Volume: 9 Issue: 10 Pages: e110013-e110013

    • DOI

      10.1371/journal.pone.0110013

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 最新臨床高血圧学 「血管リモデリング」2014

    • Author(s)
      網谷英介 小室一成
    • Journal Title

      日本臨床

      Volume: 72 Pages: 56-60

    • Related Report
      2014 Research-status Report
  • [Journal Article] Renin blockade : a double-edged sword?2014

    • Author(s)
      Amiya E, Ozeki A, Watanabe M
    • Journal Title

      Receptors and Clinical Investigation

      Volume: 1

    • DOI

      10.14800/rci.357

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Different clinical courses between various immunosuppressive regimens after heart transplantation2017

    • Author(s)
      網谷英介、波多野将、他
    • Organizer
      第81回日本循環器学会学術集会
    • Place of Presentation
      金沢
    • Year and Date
      2017-03-17
    • Related Report
      2016 Research-status Report
  • [Presentation] The Determinants of Respiratory Muscle Fatigue in Patients with Heart Failure2017

    • Author(s)
      田屋雅信、網谷英介、他
    • Organizer
      第81回日本循環器学会学術集会
    • Place of Presentation
      金沢
    • Year and Date
      2017-03-17
    • Related Report
      2016 Research-status Report
  • [Presentation] Influence of Atrial Fibrillation on Oxygen Uptake and Exercise Tolerance in Cardiac Rehabilitation2017

    • Author(s)
      高野奈実、網谷英介、他
    • Organizer
      第81回日本循環器学会学術集会
    • Place of Presentation
      金沢
    • Year and Date
      2017-03-17
    • Related Report
      2016 Research-status Report
  • [Presentation] The utility of Controlling Nutritional Status score as a prognostic index in patients with Left Ventricular Assist Device.2017

    • Author(s)
      Akihito Saito, Eisuke Amiya, Masaru Hatano, Yasuyuki Shiraishi, Daisuke Nitta, Hisataka Maki, Yumiko Hosoya, Masaki Tsuji, Kan Nawata, Osamu Kinoshita, Mitsutoshi Kimura, Miyoko Endo, Yukie Kagami, Mariko Nemoto, Minoru Ono, Issei Komuro
    • Organizer
      The International Society of Mechanical Circulatory Support
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 心疾患患者の運動時呼吸筋疲労を規定する因子の検討2017

    • Author(s)
      田屋、網谷、波多野、齊藤、新田、皆月、牧、中山、横田、渡辺、小室、芳賀
    • Organizer
      第23回日本心臓リハビリテーション学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 重症心不全患者に対する運動療法と活動歩数への指導介入の効果について2016

    • Author(s)
      田屋雅信、網谷英介、波多野将、他
    • Organizer
      第22回心臓リハビリテーション学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2016-07-16
    • Related Report
      2016 Research-status Report
  • [Presentation] 兵頭佳奈子、高山直子、網谷英介、他2016

    • Author(s)
      心臓リハビリテーションにおけるタイプDパーソナリティの変化と年齢の関係
    • Organizer
      第22回心臓リハビリテーション学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2016-07-16
    • Related Report
      2016 Research-status Report
  • [Presentation] 田屋雅信、網谷英介、兵頭佳奈子、高山直子、他2016

    • Author(s)
      タイプDパーソナリティ―の有無は外来心臓リハビリテーションによる身体機能の変化に影響しない
    • Organizer
      第22回心臓リハビリテーション学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2016-07-16
    • Related Report
      2016 Research-status Report
  • [Presentation] 高野奈実、網谷英介、小栗岳、他2016

    • Author(s)
      心房細動が運動耐容能と酸素摂取量へ与える影響
    • Organizer
      第22回心臓リハビリテーション学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2016-07-16
    • Related Report
      2016 Research-status Report
  • [Presentation] 重症心不全患者に対する運動療法の効果についてー耐糖能障害を中心にー2016

    • Author(s)
      田屋、網谷、波多野ら
    • Organizer
      第80回日本循環器学会総会
    • Place of Presentation
      仙台(仙台国際センター)
    • Year and Date
      2016-03-18
    • Related Report
      2015 Research-status Report
  • [Presentation] 各臓器移植におけるTDMとQCの重要性2016

    • Author(s)
      網谷英介
    • Organizer
      第1回TDM-QCワークショップ
    • Place of Presentation
      慶応義塾大学日吉キャンパス
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 心臓移植後のカルシニューリン阻害薬の違いによる臨床経過の違い2016

    • Author(s)
      網谷英介、波多野将、新田大介、他
    • Organizer
      第35回日本心臓移植研究会
    • Place of Presentation
      ホテルさっぽろ芸文館
    • Related Report
      2016 Research-status Report
  • [Presentation] IPAQ score can predict CAVI improvement in high-risk diabetes patients2015

    • Author(s)
      Iwasa T, Ando J, Amiya E et al
    • Organizer
      日本循環器学会
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-24 – 2015-04-26
    • Related Report
      2014 Research-status Report
  • [Presentation] 重症心不全患者に対するインターバルトレーニングの安全性と骨格筋機能への効果について2015

    • Author(s)
      田屋雅信 網谷英介 横田一彦 中山敦子 波多野将 他
    • Organizer
      日本循環器学会
    • Place of Presentation
      大阪
    • Year and Date
      2015-04-24 – 2015-04-26
    • Related Report
      2014 Research-status Report
  • [Presentation] 重症心不全患者に対するインターバルトレーニングの安全性と骨格筋機能への効果について2015

    • Author(s)
      田屋、網谷、波多野ら
    • Organizer
      第79回日本循環器学会総会
    • Place of Presentation
      大阪(大阪国際会議場)
    • Year and Date
      2015-04-22
    • Related Report
      2015 Research-status Report
  • [Presentation] IPAQ Score Can Predict CAVI Improvement in High-risk Diabetes Patients2015

    • Author(s)
      岩佐、網谷、安東ら
    • Organizer
      第79回日本循環器学会総会
    • Place of Presentation
      大阪(大阪国際会議場)
    • Year and Date
      2015-04-22
    • Related Report
      2015 Research-status Report
  • [Presentation] Difference in eNOS expression and oxidative stress between fibrotic and calcific aortic stenosis2014

    • Author(s)
      Takata M, Amiya E, Watanabe M, Sakuma K, Shintani Y et al
    • Organizer
      ESC congress
    • Place of Presentation
      Barcelona
    • Year and Date
      2014-08-30 – 2014-09-03
    • Related Report
      2014 Research-status Report
  • [Presentation] 重症心不全に対してインターバルトレーニングを導入した症例2014

    • Author(s)
      田屋雅信 網谷英介 横田一彦 中山敦子 渡辺昌文 他
    • Organizer
      日本理学療法学術大会
    • Place of Presentation
      東京
    • Year and Date
      2014-07-26
    • Related Report
      2014 Research-status Report
  • [Presentation] Endothelial Cellular Cholesterol Content Affects the Behavior of Endothelial Microparticles2014

    • Author(s)
      Amiya E, Watanabe M, Komuro I
    • Organizer
      International Vascular Biology Meeting
    • Place of Presentation
      京都
    • Year and Date
      2014-04-14 – 2014-04-17
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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