Prediction for estimating the degree of damaged pulmonary vascular bed using blood biomarkers
| Project/Area Number |
26461106
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
Kondo Takahisa 名古屋大学, 医学系研究科, 寄附講座教授 (00303644)
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| Co-Investigator(Kenkyū-buntansha) |
平敷 安希博 名古屋大学, 医学系研究科, 寄附講座助教 (10418741)
足立 史郎 名古屋大学, 医学系研究科, 寄附講座助教 (60782430)
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| Research Collaborator |
SHIMAZU Shuzo 名古屋大学, 大学院医学系研究科・循環器内科学, 大学院生
NAKANO Yoshihisa 名古屋大学, 大学院医学系研究科・循環器内科学, 研究生
KAMIMURA Yoshihiro 名古屋大学, 大学院医学系研究科・循環器内科学, 大学院生
SHIMOKATA Shigetake 名古屋大学, 大学院医学系研究科・循環器内科学, 大学院生
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 肺高血圧症 / 心肺運動負荷試験 / 呼気終末二酸化炭素分圧 / 肺動脈性肺高血圧症 / 慢性血栓塞栓性肺高血圧症 / バイオマーカー |
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| Outline of Final Research Achievements |
Presence of pericardial effusion, an average mean right atrial pressure of >=10mmHg, or cardiac index <2.5 L/min/m2 were associated with mortality among 81 consecutive patients diagnosed with group 1 or 1′ PH,. Left ventricular (LV) end-systolic volume index was significantly associated with mortality among 31 non-ischemic dilated cardiomyopathy (DCM) patients with PH (Group 2). The peak PETCO2 obtained by cardiopulmonary exercise testing (CPX) could provide useful prognostic markers for 12 patients with CTEPH (Group 4), but not 17 group 1 PH patients treatment with bosentan therapy. The peak PETCO2 may become a marker for estimating the degree of restored pulmonary vascular bed in group 4 PH (CTEPH).
In some PH patients, serum vascular endothelial growth factor (VEGF)165b, an inhibitory VEGF splice variant, was elevated. Study to investigate the relationship between VEGF165b and mean pulmonary arterial pressure, pulmonary vascular resistance, or cardiac index is underway.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Cardiopulmonary Exercise Testing as a Tool for Diagnosing Pulmonary Hypertension in Patients with Dilated Cardiomyopathy.2016
Author(s)
Hirashiki A, Kondo T, Okumura T, Kamimura Y, Nakano Y, Fukaya K, Sawamura A, Morimoto R, Adachi S, Takeshita K, Murohara T.
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Journal Title
Ann Noninvasive Electrocardiol.
Volume: -
Issue: 3
Pages: 263-271
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Cardiopulmonary exercise testing to evaluate the exercise capacity of patients with inoperable chronic thromboembolic pulmonary hypertension: An endothelin receptor antagonist improves the peak PETCO2.2014
Author(s)
Hirashiki A, Adachi S, Nakano Y, Kono Y, Shimazu S, Shimizu S, Morimoto R, Okumura T, Takeshita K, Yamada S, Murohara T, Kondo T.
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Journal Title
Life Sci.
Volume: -
Issue: 2
Pages: 397-403
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Cardiopulmonary exercise testing to evaluate the exercise capacity in patients with inoperable chronic thromboembolic pulmonary hypertension : an endotheline antagonist improves peak PETCO22014
Author(s)
Adachi S, Hirashiki A, Nakano Y, Kono Y, Shimazu S, Shimizu S, Morimoto R, Okumura T, Takeshita K, Yamada S, Murohara T, Kondo T.
Organizer
European Society of Cardiology Congress 2014
Place of Presentation
バルセロナ、スペイン
Year and Date
2014-08-29 – 2014-09-03
Related Report
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