Evaluation of prognostic factors and efficacy of early treatment for borderline pulmonary arterial hypertension
| Project/Area Number |
26461107
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Mie University |
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Principal Investigator |
Yamada Norikazu 三重大学, 医学系研究科, リサーチアソシエイト (60303731)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 肺高血圧症 / 早期治療介入 / 運動負荷 / 薬物治療 / 循環器 |
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| Outline of Final Research Achievements |
To eluciate the efficacy and safety the eraly pharmacological intervention for the borderline pulmonary arterial hypertension associated with connective tissue disease, we examined the hemodynamic parameters in pre- and follow-up period under exercise with right heart catheterization between treatment group and non-treatment group. Progression of abnormal response in exercise was observed in non-treatment group but not in treatment group. In conclusion, early pharmacological intervention might be safe and effective for patients with borderline pulmonary arterial hypertension to prevent pulmonary vascular remodeling.
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Report
(5 results)
Research Products
(3 results)
