| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Outline of Final Research Achievements |
Recent epidemiological studies showed that excessive intake of trans fatty acids (TFA) can be a residual risk for the development of coronary artery disease (CAD) even under medical management. We aimed to investigate the association between serum TFA concentration and CAD in Japan.
Serum TFA level was elevated in young patients with CAD, particularly in patients with thin-cap fibroatheroma. Multivariate logistic regression analysis identified TFA level as an independent risk factor for future cardiovascular events. Animal studies have indicated that TFA increases systemic inflammation and oxidative stress.
In conclusion, TFA may affect onset and vulnerability of coronary plaque. Serum TFA concentration may represent another cardiovascular risk factor during conventional risk factor management.
|
