RIsk evaluation of trans fatty acids in atherosclerosis in Japan

• Project/Area Number: 26461109
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Kobe University
• Principal Investigator: Shinke Toshiro 神戸大学, 医学部附属病院, 准教授 (60379419)
• Co-Investigator(Kenkyū-buntansha): 石田 達郎 神戸大学, 医学研究科, 特命教授 (00379413) ; 平田 健一 神戸大学, 医学研究科, 教授 (20283880)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: トランス脂肪酸 / 冠動脈疾患 / 脂質異常症 / 栄養学 / 内科 / 動脈硬化

Outline of Final Research Achievements

Recent epidemiological studies showed that excessive intake of trans fatty acids (TFA) can be a residual risk for the development of coronary artery disease (CAD) even under medical management. We aimed to investigate the association between serum TFA concentration and CAD in Japan.
Serum TFA level was elevated in young patients with CAD, particularly in patients with thin-cap fibroatheroma. Multivariate logistic regression analysis identified TFA level as an independent risk factor for future cardiovascular events. Animal studies have indicated that TFA increases systemic inflammation and oxidative stress.
In conclusion, TFA may affect onset and vulnerability of coronary plaque. Serum TFA concentration may represent another cardiovascular risk factor during conventional risk factor management.

Research Products

• [Journal Article] Excessive intake of trans fatty acid accelerates atherosclerosis through promoting inflammation and oxidative stress in a mouse model of hyperlipidemia. (2017)
  • Author(s): Monguchi T, Hara T, Hasokawa M, Nakajima H, Mori K, Toh R, Irino Y, Ishida T, Hirata KI, Shinohara M
  • Journal Title: J Cardiol Volume: 印刷中 Issue: 2 Pages: 121-127
  • DOI: 10.1016/j.jjcc.2016.12.012
  • Peer Reviewed
• [Journal Article] Effects of daily glucose fluctuations on the healing response to everolimus-eluting stent implantation as assessed using continuous glucose monitoring and optical coherence tomography (2016)
  • Author(s): Kuroda M, Shinke T, Otake H, Sugiyama D, Takaya T, Takahashi H, Terashita D, Uzu K, Tahara N, Kashiwagi D, Kuroda K, Shinkura Y, Nagasawa Y, Sakaguchi K, Hirota Y, Ogawa W, Hirata K
  • Journal Title: Cardiovasc Diabetol Volume: 15 Issue: 1 Pages: 79-79
  • DOI: 10.1186/s12933-016-0395-4
  • NAID: 120005820745
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The impact of in-stent neoatherosclerosis on long-term clinical outcomes: an observational study from the Kobe University Hospital optical coherence tomography registry (2016)
  • Author(s): Kuroda M, Otake H, Shinke T, Takaya T, Nakagawa M, Osue T, Taniguchi Y, Iwasaki M, Nishio R, Kinutani H, Konishi A, Hirata K.
  • Journal Title: EuroIntervention Volume: 12 Issue: 11 Pages: e1366-e1374
  • DOI: 10.4244/eijy15m12_05
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Serum Trans-Fatty Acid Concentration Is Elevated in Young Patients With Coronary Artery Disease in Japan (2015)
  • Author(s): Mori K, Ishida T, Yasuda T, Hasokawa M, Monguchi T, Sasaki M, Kondo K, Nakajima H, Shinohara M, Shinke T, Irino Y, Toh R, Nishimura K, Hirata K.
  • Journal Title: Circulation Journal Volume: 79 Issue: 9 Pages: 2017-2025
  • DOI: 10.1253/circj.CJ-14-0750
  • NAID: 130005095322
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Trans-fatty acid promotes thrombus formation in mice by aggravating antithrombogenic endothelial functions via Toll-like receptors. (2014)
  • Author(s): Kondo K, Ishida T, Yasuda T, Nakajima H, Mori K, Tanaka N, Mori T, Monguchi T, Shinohara M, Irino Y, Toh R, Rikitake Y, Kiyomizu K, Tomiyama Y, Yamamoto J, Hirata K.
  • Journal Title: Molecular Nutrition & Food Research Volume: 59 Issue: 4 Pages: 729-740
  • DOI: 10.1002/mnfr.201400537
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Elevated Serum Trans-fatty Acid is a Predictive Cardiovascular Risk in Japan (2017)
  • Author(s): 尾下寿彦、杜隆嗣、森健太、入野康宏、篠原正和、新家俊郎、石田達郎、平田健一
  • Organizer: 第81回日本循環器学会総会・学術集会
  • Place of Presentation: 金沢
  • Year and Date: 2017-03-17
• [Presentation] The Impact of Serum Trans Fatty Acids Concentration on Plaque Vulnerability in Patients with Coronary Artery Disease under Management of Conventional Risk Factors: Assessment via Optical Coherence Tomography (2016)
  • Author(s): Nagasawa Y, Shinke T, Toh T, Otake H, Takaya T, Kuroda M, Toba T, Takahashi H, Terashita D, Uzu K, Kashiwagi D, Kuroda K, Yuto Shinkura, Tahara N, Nagano Y, Tsukiyama Y, Yanaka K, Yamamoto H, Ishida T, Hirata K
  • Organizer: American College of Cardiology (ACC) 2016 Scientific Sessions
  • Place of Presentation: Chicago, USA
  • Year and Date: 2016-07-07
  • Int'l Joint Research
• [Presentation] 既知の危険因子に対して内服管理下の冠動脈疾患患者の残余リスクと してのトランス脂肪酸濃度とプラークの脆弱性との関連の評価 (2016)
  • Author(s): 長澤圭典、新家俊郎、杜隆嗣、大竹寛雅、高谷具史、黒田優、鳥羽敬義、高橋八大、寺下大輔、宇津賢三、柏木大嗣、黒田浩史、新倉悠人、田原奈津子、永野雄一朗、築山義朗、谷仲謙一、山本裕之、石田達郎、平田健一
  • Organizer: 第25回日本心血管インターベンション治療学会学術集会（CVIT2016)
  • Place of Presentation: 東京
  • Year and Date: 2016-07-07
• [Presentation] The Impact of Serum Trans Fatty Acids Concentration on Plaque vulnerability in Patients with Coronary Artery Disease under Management of Conventional Risk Factors: Assessment via Optical Coherence Tomography (2016)
  • Author(s): Nagasawa Y, Shinke T, Toh R, MD, Otake H, Takaya T, Kuroda M, Toba T, Takahashi H, Terashita D, Uzu K, Kashiwagi D, Kuroda K, Shinkura Y, MD; Tahara N, Nagano Y, Tsukiyama Y, Yanaka K, Yamamoto H, Ishida T, Hirata K.
  • Organizer: 65th Annual Scientific Session of American College of Cardiology
  • Place of Presentation: Chicago, USA
  • Year and Date: 2016-04-02
  • Int'l Joint Research
• [Presentation] 外因性脂質を含めた包括的な血清脂質管理の重要性 (2015)
  • Author(s): 石田達郎
  • Organizer: 日本冠疾患学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2015-11-20
  • Invited
• [Presentation] Serum Trans Fatty Acid Level impacts Coronary artery disease in Japanese Young Generation (2015)
  • Author(s): Mori K, Ishida K, Yasuda T, Nagao M, Tanaka N, Mori T, Monguchi T, Sasaki M, Nakajima N, Hara T, Honjo T, Irino Y, Shinohara M, Toh R, Hirata K
  • Organizer: 日本動脈硬化学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2015-07-10
• [Presentation] 我国におけるトランス脂肪酸の血中濃度と動脈硬化リスク (2015)
  • Author(s): 石田達郎
  • Organizer: 日本臨床栄養学会2015年度認定臨床栄養医研修会
  • Place of Presentation: 大阪
  • Year and Date: 2015-07-05
  • Invited
• [Presentation] Serum trans fatty acid concentration can be controlled by treatments with ezetimibe or EPA (2014)
  • Author(s): Takeshige Mori, Tatsuro Ishida, Nobuaki Tanaka, Tomoko Monguchi, Kenta Mori, Maki Sasaki, Kensuke Kondo, Hideto Nakajima, Tomoyuki Honjo, Tomoyuki Yasuda, Yasuyuki Irino, Ryuji Toh, Ken-ichi Hirata
  • Organizer: 第46回日本動脈硬化学会総会
  • Place of Presentation: 東京
  • Year and Date: 2014-07-10 – 2014-07-11
• [Presentation] 動脈硬化モデルマウスにおいてトランス脂肪酸が炎症・動脈硬化・酸化ストレスに及ぼす影響 (2014)
  • Author(s): 門口倫子、石田達郎、中島英人、安田知行、近藤健介、森健太、佐々木真希、篠原正和、杜隆嗣、平田健一
  • Organizer: 第14回日本NO学会学術集会
  • Place of Presentation: 佐賀
  • Year and Date: 2014-05-16 – 2014-05-17
• [Presentation] トランス脂肪酸はTLR依存性経路を介して血管内皮細胞の抗血栓作用を低下させ (2014)
  • Author(s): 近藤健介、石田達郎、安田知行、長尾学、森健茂、田中伸明、門口倫子、森健太、佐々木真希、中島英人、杜隆嗣、平田健一
  • Organizer: 第14回日本NO学会学術集会
  • Place of Presentation: 佐賀
  • Year and Date: 2014-05-16 – 2014-05-17