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Role of ROCK in diabetes-mediated cardiovascular disease: from bench to bedside

Research Project

Project/Area Number 26461110
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionHiroshima University

Principal Investigator

NOMA KENSUKE  広島大学, 原爆放射線医科学研究所, 助教 (00379893)

Co-Investigator(Kenkyū-buntansha) 東 幸仁  広島大学, 原爆放射線医科学研究所, 教授 (40346490)
Research Collaborator Liao James K.  シカゴ大学, メディカルセンター 循環器科, 教授
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsROCK / 糖尿病 / 血管内皮機能 / 心血管障害 / 国際情報交流 米国 / 国際情報交流 / 米国
Outline of Final Research Achievements

From the rsults in endothelial cell and animal studies, we have found that high glucose inhibited endothelial function, and activated ROCK activity and ROS generation, all of which were reversed by adminstration of ROCK inhibitor. From the result in clinical study, ROCK activity was increased in diabetes patients compared to non-diabetes subjects. These results indicate not only that ROCK could be a therapeutic target in diabets-evoked cardiovascular disease, but also that ROCK activity could be an useful biomarker of cardiovascular outcome in such patients.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (5 results)

All 2016 2015 Other

All Int'l Joint Research (2 results) Presentation (3 results) (of which Int'l Joint Research: 1 results,  Invited: 3 results)

  • [Int'l Joint Research] Section of Cardiology/University Chicago Medical Center(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Section of Cardiology/University of Chicago Medical Center(米国)

    • Related Report
      2015 Research-status Report
  • [Presentation] ROCK蛋白から斬った動脈硬化症:トランスレーショナル研究2016

    • Author(s)
      野間玄督、丸橋達也、木原康樹、東幸仁
    • Organizer
      日本薬理学会
    • Place of Presentation
      神奈川 (横浜)
    • Year and Date
      2016-03-09
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] ROCKをターゲットとした心肥大 / 心疾患における治療戦略2016

    • Author(s)
      野間玄督、木原康樹、東幸仁
    • Organizer
      第2回J-ISCP (国際心血管薬物療法学会 日本部会)
    • Place of Presentation
      徳島
    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 外因性NOはROCK活性の抑制を介して心血管疾患を制御する:トランスレーショナル研究2015

    • Author(s)
      野間玄督、丸橋達也、木原康樹、東幸仁
    • Organizer
      第51回高血圧関連疾患モデル学会
    • Place of Presentation
      大阪
    • Year and Date
      2015-10-30
    • Related Report
      2015 Research-status Report
    • Invited

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Published: 2014-04-04   Modified: 2018-03-22  

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