| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Outline of Final Research Achievements |
We demonstrated that neovascularization and inflammatory cell infiltration are associated with non-calcified plaque detected by coronary CT angiography in coronary adiposity tissue, which are resected in patients undergoing open heart surgery. Our results suggested the hypothesis that coronary atherosclerosis is reflected from coronary advential inflammation and neovascularization.
Periaortitis which is a complication of IgG4 related disease (IgG4-RD) has elevated serum c-reactive (CRP) protein levels. It is well known that disorder of T- cell type 2 or regulatory T cell may cause the pathogenesis of IgG4-RD. Our findings suggested that IgG4-periaortitis may be associated with atherosclerotic plaque, and elevated CRP may be reflected by vascular inflammation.
|
