Immnunological disorder for coronary atherosclerosis in epicardial tissue

• Project/Area Number: 26461111
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Hiroshima University
• Principal Investigator: Yamamoto Hideya 広島大学, 医歯薬保健学研究院(医), 准教授 (70335678)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 冠動脈粥状硬化 / 免疫グロブリン（IｇG4) / 炎症 / 内臓脂肪 / 冠動脈プラーク / 心膜脂肪 / 石灰化 / IgG4 / 血管新生 / 動脈周囲炎 / 心膜脂肪組織 / 肥満 / メタボリック症候群

Outline of Final Research Achievements

We demonstrated that neovascularization and inflammatory cell infiltration are associated with non-calcified plaque detected by coronary CT angiography in coronary adiposity tissue, which are resected in patients undergoing open heart surgery. Our results suggested the hypothesis that coronary atherosclerosis is reflected from coronary advential inflammation and neovascularization.
Periaortitis which is a complication of IgG4 related disease (IgG4-RD) has elevated serum c-reactive (CRP) protein levels. It is well known that disorder of T- cell type 2 or regulatory T cell may cause the pathogenesis of IgG4-RD. Our findings suggested that IgG4-periaortitis may be associated with atherosclerotic plaque, and elevated CRP may be reflected by vascular inflammation.

Research Products

• [Journal Article] Clinical features and predictive value of serum inflammatory markers of perivascular involvement in immunoglobulin G4-related disease (2017)
  • Author(s): Yamamoto H., Sugiyama E., Serikawa M, Tatsugami F, Yokozaki M, Kitagawa T, Senoo A, Kubo-Nakamoto Y, Awai K, Chayama K, Kihara Y.
  • Journal Title: Heart and Vessels Volume: - Issue: 10 Pages: 1176-1185
  • DOI: 10.1007/s00380-017-0987-2
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 18F-Sodium fluoride positron emission tomography for molecular imaging of coronary atherosclerosis based on computed tomography analysis Atherosclerosis (2017)
  • Author(s): Kitagawa T, Yamamoto H, Toshimitsu S, Sasaki K, Senoo A, Kubo Y, Tatsugami F, Awai K, Hirokawa Y, Kihara Y.
  • Journal Title: Atherosclerosis Volume: - Pages: 385-392
  • DOI: 10.1016/j.atherosclerosis.2017.04.024
  • Peer Reviewed / Open Access
• [Journal Article] Second derivative of the finger photoplethysmogram and cardiovascular mortality in middle-aged and elderly Japanese women. (2017)
  • Author(s): Inoue N, Kawakami H, Yamamoto H, Ito C, Fujiwara S, Sasaki H, Kihara Y.
  • Journal Title: Hypertens Res Volume: 40(2): Issue: 2 Pages: 207-211
  • DOI: 10.1038/hr.2016.123
  • Peer Reviewed / Open Access
• [Journal Article] Lower Radiation Exposure Needs Lower Heart Rate (2016)
  • Author(s): Yamamoto H, Kihara Y.
  • Journal Title: Circulation Journal Volume: 80 Issue: 5 Pages: 1106-1107
  • DOI: 10.1253/circj.CJ-16-0281
  • NAID: 130005147662
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Identifying Small Coronary Calcification in Non-Contrast 0.5-mm Slice Reconstruction to Diagnose Coronary Artery Disease in Patients with a Conventional Zero Coronary Artery Calcium Score. (2016)
  • Author(s): Urabe Y, Yamamoto H, Kitagawa T, Utsunomiya H, Tsushima H, Tatsugami F, Awai K, Kihara Y.
  • Journal Title: J Atheroscler Thromb Volume: 23 (12) Pages: 1324-1333
  • NAID: 130005171041
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The relationship between inflammation and neoangiogenesis of epicardial adipose tissue and coronary atherosclerosis based on computed tomography analysis. (2015)
  • Author(s): Kitagawa T, Yamamoto H, Sentani K, Takahashi S, Tsushima H, Senoo A, Yasui W, Sueda T, Kihara Y.
  • Journal Title: Atherosclerosis. Volume: 243(1) Issue: 1 Pages: 293-9
  • DOI: 10.1016/j.atherosclerosis.2015.09.013
  • Peer Reviewed / Open Access
• [Journal Article] Association between the Postprandial Glucose Levels and Arterial Stiffness Measured According to the Cardio-ankle Vascular Index in Non-diabetic Subjects (2015)
  • Author(s): Tsuboi A, Ito C, Fujikawa R, Yamamoto H, Kihara Y.
  • Journal Title: Internal Medicine Volume: 54 Issue: 16 Pages: 1961-1969
  • DOI: 10.2169/internalmedicine.54.3596
  • NAID: 130005092890
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access
• [Journal Article] Accumulation of epicardial adipose tissue increases coronary morbidity in non-obese patients with suspected coronary artery disease (2015)
  • Author(s): Yamamoto H, Kitagawa T, Kunita E, Tsushima H, Tatsugami F, Awai K, Kihara Y
  • Journal Title: IJC Metabolic & Endocrine Volume: 8 Pages: 7-12
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Data set for volumetric and pathological findings of epicardial adipose tissue. (2015)
  • Author(s): Kitagawa T, Yamamoto H, Sentani K, Takahashi S, Tsushima H, Senoo A, Yasui W, Sueda T, Kihara Y.
  • Journal Title: Data Brief. Volume: 5 Pages: 337-41
  • DOI: 10.1016/j.dib.2015.09.016
  • Peer Reviewed / Open Access
• [Journal Article] Association of Epicardial and Abdominal Visceral Adipose Tissue With Coronary Atherosclerosis in Patients With a Coronary Artery Calcium Score of Zero (2015)
  • Author(s): Tsushima H, Yamamoto H, Kitagawa T, Urabe Y, Tatsugami F, Awai K, Kihara Y.
  • Journal Title: Circulation Journal Volume: 79 Issue: 5 Pages: 1084-1091
  • DOI: 10.1253/circj.CJ-14-1169
  • NAID: 130005066258
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Radiation dose reduction for coronary artery calcium scoring at 320-detector CT with adaptive iterative dose reduction 3D. (2015)
  • Author(s): Tatsugami F, Higaki T, Fukumoto W, Kaichi Y, Fujioka C, Kiguchi M, Yamamoto H, Kihara Y, Awai K.
  • Journal Title: Int J Cardiovasc Imaging. Volume: 31(5) Issue: 5 Pages: 1045-52
  • DOI: 10.1007/s10554-015-0637-7
  • Peer Reviewed / Open Access
• [Journal Article] Risk Factors for Progression of Degenerative Aortic Valve Disease in the Japanese – The Japanese Aortic Stenosis Study (JASS) Prospective Analysis – (2015)
  • Author(s): Yamamoto K, Yamamoto H, Takeuchi M, Kisanuki A, Akasaka T, Ohte N, Hirano Y, Yoshida K, Nakatani S, Takeda Y, Sozu T, Masuyama T.
  • Journal Title: Circulation Journal Volume: 79 Issue: 9 Pages: 2050-2057
  • DOI: 10.1253/circj.CJ-15-0499
  • NAID: 130005095298
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Accumulation of epicardial adipose tissue increases coronary morbidity in non-obese patients with suspected coronary artery disease (2015)
  • Author(s): Yamamoto H, Kunita E, Kitagawa T, Tsushima H, Tatsugami F, Awai K, Kihara Y.
  • Journal Title: Int J Cardiol Metabolic and Endocrine Volume: in press
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] The non-invasive Physiologycal Detection of Myocardial Ischemia in Coronary Aretery Diseasae (2017)
  • Author(s): Hakimi M, Kisaka T, Yamamoto H, Wasserman K, Budoff M.
  • Organizer: American College of Cardiology 2017
  • Place of Presentation: Washington DC USA
  • Year and Date: 2017-03-16
  • Int'l Joint Research
• [Presentation] Clinical features and predictive value of serum inflammatory markers of perivascular involvement in immunoglobulin G4-related disease (2017)
  • Author(s): Yamamoto H., Sugiyama E., Serikawa M, Tatsugami F, Yokozaki M, Kitagawa T, Senoo A, Kubo-Nakamoto Y, Awai K, Chayama K, Kihara Y.
  • Organizer: The 81 annual Meeting of Japanese Circulation Society
  • Place of Presentation: 金沢市
  • Year and Date: 2017-03-16
• [Presentation] Impact of Pathological Features of Epicardial Adipose Tissue on Coronary Plaque Characteristics Verified on Computed Tomography Angiography (2017)
  • Author(s): Senoo A, Kitagawa T, Yamamoto H, Takahashi S, Kubo Y, Sueda T, Kihara Y.
  • Organizer: The 81 annual Meeting of Japanese Circulation Society
  • Place of Presentation: 金沢市
  • Year and Date: 2017-03-16
• [Presentation] Contribution of Inflammatory Cytokines in Epicardial Adipose Tissue to Coronary Atherosclerosis Based on Computed Tomography Analysis (2017)
  • Author(s): Kitagawa T, Senoo A, Takahashi S, Yamamoto H, Sueda T, Kihara Y
  • Organizer: The 81 annual Meeting of Japanese Circulation Society
  • Place of Presentation: 金沢市
  • Year and Date: 2017-03-16
• [Presentation] 18F-Sodium Fluoride Positron Emission Tomography for Molecular Imaging of Coronary Atherosclerosis Based on Computed Tomography Analysis (2016)
  • Author(s): Kitagawa T, Yamamoto H, Toshimitsu S, Sasaki K, Senoo A, Hirokawa Y, Kihara Y
  • Organizer: American Heart Association 2016
  • Place of Presentation: New Orleans USA
  • Year and Date: 2016-11-12
  • Int'l Joint Research
• [Presentation] Frequency and Clinical Manifestations of Cardiovascular Complication in IgG4-Related Disease (2016)
  • Author(s): Yamamoto H, KitagawaT,Kihara Y.
  • Organizer: 第80回日本循環器病学会学術総会
  • Place of Presentation: 仙台市
  • Year and Date: 2016-03-18
• [Presentation] Relation of Inflammation and Neoangiogenesis of Epicardial Adipose Tissue to CoronaryAtherosclerosis Based on Computed Tomography Analysis (2015)
  • Author(s): Toshiro Kitagawa, Hiroshi Tsushima, Hideya Yamamoto, Yasuki Kihara
  • Organizer: JCS2015
  • Place of Presentation: 大阪市
  • Year and Date: 2015-04-24 – 2015-04-26
• [Remarks] UMIN000010654 CRT UMIN000010654
  • URL: https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr.cgi?function=brows&action=brows&type=summary&recptno=R000012461&language=J
• [Remarks] 広島大学研究者総覧
  • URL: http://seeds.office.hiroshima-u.ac.jp/profile/ja.76ad15de1ff76244520e17560c007669.html