| Project/Area Number |
26461112
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Ehime University |
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Principal Investigator |
Higaki Jitsuo 愛媛大学, 医学系研究科, 教授 (70189744)
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| Co-Investigator(Kenkyū-buntansha) |
大蔵 隆文 愛媛大学, 医学系研究科, 准教授 (40260385)
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| Co-Investigator(Renkei-kenkyūsha) |
Miyoshi Kenichi 愛媛大学, 大学院医学系研究科, 講師 (50423439)
Irita Jun 愛媛大学, 医学部附属病院, 講師 (00423442)
Nagao Tomoaki 愛媛大学, 医学部附属病院, 医員 (20512164)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | オステオポンチン / アテローム血栓性脳梗塞 / thrombin cleaved / osteopontin / 血栓症 |
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| Outline of Final Research Achievements |
We investigated whether thrombin-cleaved osteopontin (N-half OPN) is useful as a biomarker of acute atherothrombotic stroke. They were divided into the atherothrombotic and non-atherothrombotic groups. N-half OPN, MMP-9 were measured at admission. After excluding patients who met the exclusion criteria, 60 of the 100 patients enrolled in this study. The ischemic stroke subtypes were atherothrombotic (n=28.4%), cardioembolic (n=19.3%) and lacunar (n=13.2%). N-half OPN and MMP-9 levels were significantly higher in the atherothrombotic than in the non-atherothrombotic group. After adjustment for the prevalence of hypertension, diabetes and dyslipidemia, N-half OPN levels of 5.47 pmol/l and MMP-9 levels of >605.5 ng/ml were identified as independent predictors of atherothrombosis. Within 3 hours from stroke onset, only N-half OPN independently predicted atherothrombotic stroke, suggesting usefulness of N-half OPN for diagnosis of the early evaluation of ischemic stroke.
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