Exploratory study of novel oxidative stress markers for early diagnosis of pulmonary hypertension

• Project/Area Number: 26461113
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Nagasaki University
• Principal Investigator: IKEDA Satoshi 長崎大学, 医歯薬学総合研究科(医学系), 講師 (10336159)
• Co-Investigator(Kenkyū-buntansha): 浦田 芳重 長崎大学, 医歯薬学総合研究科(医学系), 助教 (30185087) ; 前村 浩二 長崎大学, 医歯薬学総合研究科(医学系), 教授 (90282649)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 肺高血圧症 / 酸化ストレス / 肺高血圧

Outline of Final Research Achievements

The prognosis of pulmonary arterial hypertension (PAH) is poor; therefore, early diagnosis and treatment is required. However, the useful biomarkers for the diagnosis have not been established. In the present study, we examined whether oxidative stress-related proteins, such as glutathionylated protein and PGC-1α, could be the biomarkers, because oxidative stress is involved in PAH development and progression. As a result, the expression of the two proteins did not differ between PAH model and control animal. We concluded that these proteins were not good biomarkers for the diagnosis of PAH.

Research Products

• [Journal Article] Comparison of the effects of edoxaban, an oral direct factor Xa inhibitor, on venous thromboembolism between patients with and without cancer. (2018)
  • Author(s): Ikeda S, Koga S, Yamagata Y, Eguchi M, Sato D, Muroya T, Yonekura T, Tsuneto A, Yoshimuta T, Koide Y, Kawano H, Maemura K.
  • Journal Title: J Cardiol Volume: 印刷中 Issue: 2 Pages: 120-127
  • DOI: 10.1016/j.jjcc.2018.03.006
  • Peer Reviewed / Open Access
• [Journal Article] Deeper S Wave in Lead V5 and Broader Extent of T Wave Inversions in the Precordial Leads are Clinically Useful Electrocardiographic Parameters for Predicting Pulmonary Hypertension (2018)
  • Author(s): Miura M, Ikeda S, Yoshida T, Yamagata Y, Nakata T, Koga S, Koide Y, Kawano H, Maemura K.
  • Journal Title: International Heart Journal Volume: 59 Issue: 1 Pages: 136-142
  • DOI: 10.1536/ihj.16-647
  • NAID: 130006321377
  • ISSN: 1349-2365, 1349-3299
  • Peer Reviewed / Open Access
• [Journal Article] Balloon pulmonary angioplasty is effective for treating peripheral-type chronic thromboembolic pulmonary hypertension in elderly patients. (2018)
  • Author(s): Yamagata Y, Ikeda S, Nakata T, Yonekura T, Koga S, Muroya T, Koide Y, Kawano H, Maemura K.
  • Journal Title: Geriatrics & Gerontology International Volume: 印刷中 Issue: 5 Pages: 678-684
  • DOI: 10.1111/ggi.13224
  • Peer Reviewed / Open Access
• [Journal Article] Deeper S wave in lead V5 and broader extent of T wave inversions in the precordial leads are clinically useful electrocardiographic parameters for predicting pulmonary hypertension (2017)
  • Author(s): Miyuki Miura, Satoshi Ikeda, Takeo Yoshida, Yuki Yamagata, Tomoo Nakata, Seiji Koga, Yuji Koide, Hiroaki Kawano, Koji Maemura
  • Journal Title: International Heart Journal Volume: 印刷中
  • NAID: 130006321377
  • Peer Reviewed
• [Presentation] 担癌患者の静脈血栓症治療におけるDOACの有用性 (2018)
  • Author(s): 池田聡司
  • Organizer: 第82回日本循環器学会学術集会
  • Int'l Joint Research / Invited
• [Presentation] Comparative effects of factor Xa inhibitors on venous thromboembolism in patients with and without cancer (2018)
  • Author(s): Sato D, Ikeda S, Yamagata Y, Koga S, Eguchi M, Koide Y, kawano H, Maemura K
  • Organizer: The 82th Annual Scientific Meeting of the Japanese Circulation Society
  • Int'l Joint Research
• [Presentation] The differences of right-sided heart function assessed by speckle tracking analysis between chronic thromboembolic pulmonary hypertension and pulmonary arterial hypertension. (2018)
  • Author(s): 山方勇樹、池田聡司、中田智夫、米倉剛、古賀聖士、室屋隆浩、小出優史、河野浩章、前村浩二
  • Organizer: The 82th Annual Scientific Meeting of the Japanese Circulation Society
  • Int'l Joint Research
• [Presentation] Plasma levels of Oxidative Stress-Responsive Apoptosis Inducing Protein (ORAIP) is associated with pulmonary hemodynamics in patients with pulmonary hypertension. (2018)
  • Author(s): 山方勇樹、池田聡司、中田智夫、米倉剛、江口正倫、古賀聖士、室屋隆浩、小出優史、河野浩章、八尾貴子、世古義規、前村浩二
  • Organizer: The 82th Annual Scientific Meeting of the Japanese Circulation Society
  • Int'l Joint Research