Exploratory study of novel oxidative stress markers for early diagnosis of pulmonary hypertension
Project/Area Number |
26461113
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Cardiovascular medicine
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Research Institution | Nagasaki University |
Principal Investigator |
IKEDA Satoshi 長崎大学, 医歯薬学総合研究科(医学系), 講師 (10336159)
|
Co-Investigator(Kenkyū-buntansha) |
浦田 芳重 長崎大学, 医歯薬学総合研究科(医学系), 助教 (30185087)
前村 浩二 長崎大学, 医歯薬学総合研究科(医学系), 教授 (90282649)
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Project Period (FY) |
2014-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 肺高血圧症 / 酸化ストレス / 肺高血圧 |
Outline of Final Research Achievements |
The prognosis of pulmonary arterial hypertension (PAH) is poor; therefore, early diagnosis and treatment is required. However, the useful biomarkers for the diagnosis have not been established. In the present study, we examined whether oxidative stress-related proteins, such as glutathionylated protein and PGC-1α, could be the biomarkers, because oxidative stress is involved in PAH development and progression. As a result, the expression of the two proteins did not differ between PAH model and control animal. We concluded that these proteins were not good biomarkers for the diagnosis of PAH.
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Report
(5 results)
Research Products
(8 results)
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[Journal Article] Comparison of the effects of edoxaban, an oral direct factor Xa inhibitor, on venous thromboembolism between patients with and without cancer.2018
Author(s)
Ikeda S, Koga S, Yamagata Y, Eguchi M, Sato D, Muroya T, Yonekura T, Tsuneto A, Yoshimuta T, Koide Y, Kawano H, Maemura K.
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Journal Title
J Cardiol
Volume: 印刷中
Issue: 2
Pages: 120-127
DOI
Related Report
Peer Reviewed / Open Access
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