| Project/Area Number |
26461114
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
Toshio Imanishi 和歌山県立医科大学, 医学部, 博士研究員 (00285389)
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| Co-Investigator(Kenkyū-buntansha) |
尾崎 雄一 和歌山県立医科大学, 医学部, その他 (00507999)
樽谷 玲 和歌山県立医科大学, 医学部, 学内助教 (60612942)
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| Co-Investigator(Renkei-kenkyūsha) |
Taruya Rei 和歌山県立医科大学, 医学部, 博士研究員 (60612942)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 不安定プラーク / 急性冠症候群 / 単球 / 冠血管イメージング / 冠動脈プラーク |
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| Outline of Final Research Achievements |
We investigated the relationship using 64-slive multidirector computed tomography (MDCT) in patients with stable angina pectoris (SAP). We enrolled 65 patients with SAP who underwent MDCT. Three monocyte subsets (CD14++CD16-, CD14++CD16+, and CD14+CD16+) and expression of TLR-4 were measured by flow cytometry. Intracoronary plaques were assessed by 64-slice MDCT.The circulating CD14++CD16+ monocytes more frequently expressed TLR-4 than CD14++CD16- and CD14+CD16+ monocytes (P<0.001). The relative proportion of the expression of TLR-4 on CD14++CD16+ monocytes was significantly greater in patients with vulnerable plaque compared with those without. In addition, the relative proportion of TLR-4 expression on CD14++CD16+ monocytes positively correlated with the remodeling index and negatively correlated with CT attenuation value. In conclusion, upregulation of TLR-4 on CD14++CD16+ monocytes might be associated with coronary plaque vulnerability in patients with SAP.
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