Vulnerability Characteristics of Coronary Plaque

• Project/Area Number: 26461114
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Wakayama Medical University
• Principal Investigator: Toshio Imanishi 和歌山県立医科大学, 医学部, 博士研究員 (00285389)
• Co-Investigator(Kenkyū-buntansha): 尾崎 雄一 和歌山県立医科大学, 医学部, その他 (00507999) ; 樽谷 玲 和歌山県立医科大学, 医学部, 学内助教 (60612942)
• Co-Investigator(Renkei-kenkyūsha): Taruya Rei 和歌山県立医科大学, 医学部, 博士研究員 (60612942)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 不安定プラーク / 急性冠症候群 / 単球 / 冠血管イメージング / 冠動脈プラーク

Outline of Final Research Achievements

We investigated the relationship using 64-slive multidirector computed tomography (MDCT) in patients with stable angina pectoris (SAP). We enrolled 65 patients with SAP who underwent MDCT. Three monocyte subsets (CD14++CD16-, CD14++CD16+, and CD14+CD16+) and expression of TLR-4 were measured by flow cytometry. Intracoronary plaques were assessed by 64-slice MDCT.The circulating CD14++CD16+ monocytes more frequently expressed TLR-4 than CD14++CD16- and CD14+CD16+ monocytes (P<0.001). The relative proportion of the expression of TLR-4 on CD14++CD16+ monocytes was significantly greater in patients with vulnerable plaque compared with those without. In addition, the relative proportion of TLR-4 expression on CD14++CD16+ monocytes positively correlated with the remodeling index and negatively correlated with CT attenuation value. In conclusion, upregulation of TLR-4 on CD14++CD16+ monocytes might be associated with coronary plaque vulnerability in patients with SAP.

Research Products

• [Journal Article] Association of Toll-Like Receptor 4 on Human Monocyte Subsets and Vulnerability Characteristics of Coronary Plaque as Assessed by 64-Slice Multidetector Computed Tomography (2017)
  • Author(s): Ozaki Y, Imanishi T, Hosokawa S, Nishiguchi T, Taruya A, Tanimoto T, Kuroi A, Yamano T, Matsuo Y, Ino Y, Kitabata H, Kubo T, Tanaka A, Akasaka T.
  • Journal Title: Circulation Journal Volume: 81 Issue: 6 Pages: 837-845
  • DOI: 10.1253/circj.CJ-16-0688
  • NAID: 130005679700
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Circulating CD!4++CD16+ Monocyte Subsets as a Surrogate Marker of the Therapeutic Effect of Corticosteroid Therapy In Patients Wit Cardiac Sarcoidosis (2015)
  • Author(s): Orii M, Imanishi T, et al
  • Journal Title: Circ J Volume: 79 Pages: 1585-1592
  • Peer Reviewed
• [Journal Article] Association between P-selectin glycoprotein ligand-1 and pathogenesis in acute coronary syndrome assessed by optical coherence tomography (2014)
  • Author(s): Ozaki Y, Imanishi T et al.
  • Journal Title: Atherosclerosis Volume: 233 Pages: 697-703
• [Journal Article] Effect of direct renin inhibitor on left ventrilcuar remodeling in patients with primary acute myocardila infarction (2014)
  • Author(s): Ozaki Y, Imansihi T, et al.
  • Journal Title: Int. Heart J Volume: 55 Pages: 17-21