Development of the role of midkine on the cardio-renal association

• Project/Area Number: 26461121
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Yamagata University
• Principal Investigator: SHISHIDO Tetsuro 山形大学, 医学部, 助教 (60400545)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: ミッドカイン / 心肥大 / 腎不全 / 腎機能障害 / 心不全 / 心筋細胞

Outline of Final Research Achievements

It has knwon that cardiac remodeling is observed during chronic kideny disease. We found that levels of midkine in the kidney and serum has beed increased before remodeling occured. Circulating midkne modulates intracellular signaling through GPCR, and induces cardiac hypertrophy, including increased ANP expressions.

Research Products

• [Int'l Joint Research] Department of Cardiology/University of Texas/MD Anderson Cancer Center(米国)
• [Int'l Joint Research] Department of Pharmacology,/College of Medicine/Yeungnam University(韓国)
• [Journal Article] Midkine Deteriorates Cardiac Remodeling via Epidermal Growth Factor Receptor Signaling in Chronic Kidney Disease. (2016)
  • Author(s): Honda Y, Shishido T, Takahashi T, Watanabe T, Netsu S, Kinoshita D, Narumi T, Kadowaki S, Nishiyama S, Takahashi H, Arimoto T, Miyamoto T, Kishida S, Kadomatsu K, Takeishi Y, Kubota I.
  • Journal Title: Hypertension. Volume: 67(5) Issue: 5 Pages: 857-865
  • DOI: 10.1161/hypertensionaha.115.06922
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Additive clinical value of serum brain-derived neurotrophic factor for prediction of chronic heart failure outcome. (2016)
  • Author(s): Kadowaki S. et al.
  • Journal Title: Heart Vessels. Volume: 31 Issue: 4 Pages: 535-544
  • DOI: 10.1007/s00380-015-0628-6
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Deficiency of Senescence Marker Protein 30 Exacerbates Cardiac Injury after Ischemia/Reperfusion. (2016)
  • Author(s): Kadowaki S, Shishido T, Sasaki T, Sugai T, Narumi T, Honda Y, Otaki Y, Kinoshita D, Takahashi T, Nishiyama S, Takahashi H, Arimoto T, Miyamoto T, Watanabe T, Ishigami A, Takeishi Y, Kubota I.
  • Journal Title: Int J Mol Sci. Volume: 17 Issue: 4 Pages: 542-542
  • DOI: 10.3390/ijms17040542
  • Peer Reviewed / Open Access
• [Journal Article] High-mobility group box 1-mediated heat shock protein beta 1 expression attenuates mitochondrial dysfunction and apoptosis (2015)
  • Author(s): Narumi T, Shishido T, Otaki Y, Kadowaki S, Honda Y, Funayama A, Honda S, Hasegawa H, Kinoshita D, Yokoyama M, Nishiyama S, Takahashi H, Arimoto T, Miyamoto T, Watanabe T, Tanaka A, Woo C, Abe J, Takeishi Y, Kubota I
  • Journal Title: Journal of Molecular and Cellular Cardiology Volume: 82 Pages: 1-12
  • DOI: 10.1016/j.yjmcc.2015.02.018
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Impact of serum omentin-1 levels on cardiac prognosis in patients with heart failure. (2015)
  • Author(s): Narumi T, Watanabe T, Kadowaki S, Kinoshita D, Yokoyama M, Honda Y, Otaki Y, Nishiyama S, Takahashi H, Arimoto T, Shishido T, Miyamoto T, Kubota I
  • Journal Title: Cardiovasc Diabetol. Volume: 13 Issue: 1 Pages: 84-84
  • DOI: 10.1186/1475-2840-13-84
  • Peer Reviewed / Open Access
• [Journal Article] Electrocardiographic left ventricular hypertrophy cornell product is a feasible predictor of cardiac prognosis in patients with chronic heart failure. (2014)
  • Author(s): Otaki Y, Takahashi H, Watanabe T, Kadowaki S, Narumi T, Honda Y, Hasegawa H, Honda S, Funayama A, Nishiyama, Arimoto T, Shishido T, Miyashita T, Miyamoto T, Kubota I
  • Journal Title: Clin Res Cardiol. Volume: 103 Issue: 4 Pages: 275-284
  • DOI: 10.1007/s00392-013-0646-2
  • Peer Reviewed / Open Access
• [Journal Article] Association of renal tubular damage with cardio-renal anemia syndrome in patients with heart failure. (2014)
  • Author(s): Otaki Y, Watanabe T, Takahashi H, Narumi T, Kadowaki S, Honda Y, Arimoto T, Shishido T, Miyamoto T, Konta T, Kubota I
  • Journal Title: Int J Cardiol. Volume: 173 Issue: 2 Pages: 222-228
  • DOI: 10.1016/j.ijcard.2014.02.044
  • Peer Reviewed / Open Access
• [Presentation] Cardiac nuclear High Mobility Group Box 1 in regulating cardiac remodeling (2016)
  • Author(s): 宍戸 哲郎
  • Organizer: ＩＳＨＲ
  • Place of Presentation: 東京コンベンションホール（東京都中央区）
  • Year and Date: 2016-12-15
  • Int'l Joint Research / Invited
• [Presentation] 臓器連関を介した心血管病進展機序について． (2016)
  • Author(s): 宍戸 哲郎
  • Organizer: 第3回仙台先進循環器研究会
  • Place of Presentation: MSDオフィス（宮城県仙台市）
  • Invited
• [Presentation] 心筋症患者でのHigh Mobility Group Box 1 (HMGB1)発現とその意義に関する検討． (2015)
  • Author(s): 木下大資，宍戸哲郎，高橋徹也，渡邉哲，久保田功
  • Organizer: 第1回日本心筋症研究会東京2015.07.04
  • Place of Presentation: 一橋大学（東京都千代田区）
  • Year and Date: 2015-07-04
• [Presentation] Senescence marker protein 30 protect the cardiac injury from after ischemia reperfusion. (2014)
  • Author(s): Kadowaki S, Shishido T et al.
  • Organizer: American Heart Association Scientific Sessions 2014
  • Place of Presentation: マコーミックプレイスコンベンションセンター(アメリカ合衆国シカゴ）
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] The HECT type E3 ligase ITCH ameliorates left ventricular remodeling and mortality after myocardial Infarction. (2014)
  • Author(s): Otaki Y, Watanabe T, Takahashi H, Narumi T, Kadowaki S, Honda Y, Arimoto T, Shishido T, Miyamoto T, Kubota I
  • Organizer: American Heart Association Scientific Sessions 2014
  • Place of Presentation: マコーミックプレイスコンベンションセンター(アメリカ合衆国シカゴ）
  • Year and Date: 2014-11-15 – 2014-11-19
• [Book] 医学のあゆみ (2017)
  • Author(s): 宍戸 哲郎
  • Total Pages: 3
  • Publisher: 医歯薬出版株式会社