| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Outline of Final Research Achievements |
In a failing heart, a workload of each cardiomyocyte is increased to recover cardiac function. Although the increase requires more energy, failing cardiac cells are reported not to product enough energy. High fat diet is reported to reactivate lipid metabolism and increase energy product. So, we examined whether high fat low carbon (HFLC) diet could preserve cardiac function in murine failing models via an increase of energy production.
Our results showed that HFLC did not increase energy production, but HFLC decreased cardiac hypertrophy in a pressure-overload model and preserved cardiac function in a dilated cardiomyocyte model. We are studying mechanisms of how HFLC keeps cardiac function under pathological conditions.
|
