Impacts of Dysfunction in Cardiac Macrophages on Arrhythmia
Project/Area Number |
26461125
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Cardiovascular medicine
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Research Institution | The University of Tokyo |
Principal Investigator |
Fujiu Katsuhito 東京大学, 医学部附属病院, 特任准教授 (30422306)
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Project Period (FY) |
2014-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 不整脈 / 心不全 / マクロファージ / 炎症 / 免疫細胞 / アンフィレグリン / 心臓 / 突然死 / 細胞間相互作用 |
Outline of Final Research Achievements |
We have studied the novel function of cardiac resident macrophage on cardiac physiological function. First we found the cardiac macrophage is required for its stress response against cardiac pressure overload. In addition, making cardiac rhythm is another cardiac basic role beyond cardiac contraction. Macrophage depleted mouse by clodronate liposome administration resulted in severe arrhythmia and death. These results indicated cardiac macrophages are involved in cardiac rhythm making.
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Report
(5 results)
Research Products
(30 results)
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[Journal Article] A heart-brain-kidney network controls adaptation to cardiac stress through tissue macrophage activation and cellular communication2017
Author(s)
Fujiu K, Shibata M, Nakayama Y, Ogata F, Matsumoto S, Noshita K, Iwami S, Nakae S, Komuro I, Nagai R, Manabe I
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Journal Title
Nature Medicine
Volume: 印刷中
Issue: 5
Pages: 611-622
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Electromagnetic interference between continuous-flow left ventricular assist device and cardiac resynchronization therapy defibrillator due to an unrecognized mechanism.2015
Author(s)
Yokota J, Fujiu K, Tanimito H, Nebiya H, Kashiwa K, Kinoshita O, Nawata K, Kimura M, Satsu T, Chou K, Sumitani M, Ono M, Komuro I.
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Journal Title
Int J Cardiol
Volume: 179
Pages: 510-513
DOI
Related Report
Peer Reviewed
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[Journal Article] Thoracic Spinal Cord Stimulation for Heart Failure as a Restorative Treatment (SCS HEART study): first-in-man experience.2014
Author(s)
Tse HF1, Turner S2, Sanders P3, Okuyama Y4, Fujiu K5, Cheung CW6, Russo M7, Green MD8, Yiu KH6, Chen P9, Shuto C9, Lau EO9, Siu CW6.
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Journal Title
Heart Rhythm.
Volume: 12
Issue: 3
Pages: 588-595
DOI
Related Report
Peer Reviewed
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[Journal Article] Can intensive lipid-lowering therapy improve the carotid intima-media thickness in Japanese subjects under primary prevention for cardiovascular disease?: The JART and JART extension subanalysis.2014
Author(s)
Daida H, Nohara R, Hata M, Kaku K, Kawamori R, Kishimoto J, Kurabayashi M, Masuda I, Sakuma I, Yamazaki T, Yokoi H, Yoshida M; Justification for Atherosclerosis Regression Treatment (JART) Investigators.
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Journal Title
J Atheroscler Thromb.
Volume: 21
Pages: 739-754
Related Report
Peer Reviewed
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[Presentation] HIS bundle pacing for bradycardia patients2017
Author(s)
Katsuhito Fujiu
Organizer
The joint meeting of the 10th Asia Pacific Heart Rhythm Society Scientific Session (APHRS 2017) and the 64th Annual Meeting of the Japanese Heart Rhythm Society (JHRS2017)
Related Report
Int'l Joint Research / Invited
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