Molecular pathogenesis mechanism of idiopatic ventricular fibrillation related to Semapolin 3A gene
Project/Area Number |
26461130
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Cardiovascular medicine
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Research Institution | Hiroshima University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
越智 秀典 広島大学, 医歯薬保健学研究院(医), 講師 (10415119)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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Keywords | セマフォリン3A / 特発性心室細動 / 一塩基多型 / ブルガダ症候群 / 心室細動 / 遺伝子多型 |
Outline of Final Research Achievements |
We reported that Semapholin 3A (SEMA3A) was related to occurrence of ideoventricular ventricular fibrillation (IVF). The other SNPs having an interaction with SEMA3AI334V and likely to develop VF have not found in SEMA3A tag SNP and causative genes in Brugada syndrome. There was no difference in receptor binding assay and dimer formation between SEMA3I334V and wild type. We have to continue to consider relationship between SEMA3A and pathogenesis of arrhythmia.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Genetic variations of aldehyde dehydrogenase 2 and alcohol dehydrogenase 1B are associated with the etiology of atrial fibrillation in Japanese2016
Author(s)
Nakano Y, Ochi H, Onohara Y, Sairaku A, Tokuyama T, Matsumura H, Tomomori S, Amioka M, Hironomobe N, Motoda C, Oda N, Chayama K, Chen CH, Gross ER, Mochly-Rosen D, Kihara Y
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Journal Title
J Biomed Sci
Volume: -
Issue: 1
Pages: 89-89
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Risk Stratification of Ventricular Fibrillation in Brugada Syndrome Using Noninvasive Scoring Methods2016
Author(s)
Kawazoe H, Nakano Y, Ochi H, Takagi M, Hayashi Y, Uchimura Y, Tokuyama T, Watanabe Y, Matsumura H, Tomomori S, Sairaku A, Suenari K, Awazu A, Miwa Y, Soejima K, Chayama K, Kihara Y
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Journal Title
Heart Rhythm
Volume: 13(10)
Issue: 10
Pages: 1947-54
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Common Variant Near HEY2 Has a Protective Effect on Ventricular Fibrillation Occurrence in Brugada Syndrome by Regulating the Repolarization Current.2016
Author(s)
Nakano Y, Ochi H, Onohara Y, Toshishige M, Tokuyama T, Matsumura H, Kawazoe H, Tomomori S, Sairaku A, Watanabe Y, Ikenaga H, Motoda C, Suenari K, Hayashida Y, Miki D, Oda N, Kishimoto S, Oda N, Yoshida Y, Tashiro S, Chayama K, Kihara Y.
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Journal Title
Circ Arrhythm Electrophysiol.
Volume: 9(1)
Issue: 1
DOI
Related Report
Peer Reviewed
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[Presentation] Risk Stratification of Ventricular Fibrillation in Brugada Syndrome Using Clinical and Molecular Biological Parameters is useful for Deciding an Optimal Therapeutic Strategy2017
Author(s)
Nakano Y, Kawazoe H, Ochi H, Sairaku A, Tokuyama T, Matsumura H, Tomomori S, Amioka M, Hironobe N, Motoda C, Onohara Y, Chayama K, Kihara Y
Organizer
第81回日本循環器学会学術集会
Place of Presentation
金沢
Year and Date
2017-03-17
Related Report
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[Presentation] Variants of Aldehyde Dehydrogenase 2 and Alcohol Dehydrogenase Genes are Associated with Atrial Fibrillation2017
Author(s)
Nakano Y, Ochi H, Onohara Y, Sairaku A, Tokuyama T, Matsumura H, Tomomori S, Amioka M, Hironobe N, Motoda C, Oda N, Chayama K, Kihara Y
Organizer
第81回日本循環器学会学術集会
Place of Presentation
金沢
Year and Date
2017-03-17
Related Report
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[Presentation] Variants Of Aldehyde Dehydrogenase 2 And Alcohol Dehydrogenase Genes Are Associated With Atrial Fibrillation2016
Author(s)
Nakano Y, Ochi H, Tomomori S, Matsumura H, Tokuyama T, Sairaku A, Motoda C, Chayama K, Chen C, Mochly-Rosen D, Kihara Y
Organizer
American Heart Association 2016
Place of Presentation
New Orleans,USA
Year and Date
2016-11-12
Related Report
Int'l Joint Research
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[Presentation] Risk Stratification of Ventricular Fibrillation in Brugada Syndrome Using Logistic Models of Noninvasive Parameters2016
Author(s)
Nakano Y, Kawazoe H, Ochi H, Takagi M, Tokuyama T, Sairaku A, Matsumura H, Tomomori S, Amioka M, Kihara Y
Organizer
American Heart Association 2016
Place of Presentation
New Orleans,USA
Year and Date
2016-11-12
Related Report
Int'l Joint Research
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[Presentation] Common Variant Near Hey2 as a Protective Modifier of Ventricular Fibrillation in Brugada Syndrome by Modurating QTc Interval2014
Author(s)
Nakano Y, Ochi H, Toshishige M, Tokuyama T, Kawazoe H, Watanabe Y, Matsumura M, Tomomori S, Kishimoto S, Ikenaga H, Oda N, Chayama K, Kihara Y
Organizer
The 87th Scientific Sessions of the American Heart Association 2014
Place of Presentation
Chicago, USA
Year and Date
2014-11-15 – 2014-11-19
Related Report
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[Presentation] Negative Association of H558r Polymorphism and Ventricular Fibrillation in Patients With Brugada Syndrome2014
Author(s)
Matsumura H, Nakano Y, Toshishige M, Ochi H, Tokuyama T, Watanabe Y, Kawazoe H, Tomomori S, Kishimoto S, Chayama K, Kihara Y
Organizer
The 87th Scientific Sessions of the American Heart Association 2014
Place of Presentation
Chicago, USA
Year and Date
2014-11-15 – 2014-11-19
Related Report
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