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Development of a new therapeutic strategy for cardiomyopathy by administration of mRNA

Research Project

Project/Area Number 26461135
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionNara Medical University

Principal Investigator

Onoue Kenji  奈良県立医科大学, 医学部, 助教 (90510173)

Co-Investigator(Renkei-kenkyūsha) Kataoka Kazunori  東京大学, 工学研究科, 教授 (00130245)
Itaka Keiji  東京大学, 医学系研究科, 准教授 (60292926)
Research Collaborator Wakimoto Hiroko  ハーバード大学, 遺伝学部門, 講師
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords循環器 / 心筋症 / 遺伝学 / 原因治療 / 循環器・高血圧
Outline of Final Research Achievements

The pathology of idiopathic dilated cardiomyopathy had been gradually elucidated in terms of genetic or molecular mechanisms. However, the treatment for that is still palliative in medication or mechanical support. In this study, we aimed for establish a new causal treatment by administrating a messenger RNA (mRNA) of mutationally deficient protein to a mouse model of dilated cardiomyopathy. It took much longer time than we expected for the biosynthesis of mRNA and the determination of a way of the most effective administration of that. We finally established those in 2 years and are currently working on experiments in which we can evaluate the effectiveness of this new causal treatment.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (6 results)

All 2016 2015 Other

All Int'l Joint Research (2 results) Presentation (3 results) (of which Int'l Joint Research: 2 results) Remarks (1 results)

  • [Int'l Joint Research] Harvard Medical School(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Harvard Medical School(米国)

    • Related Report
      2015 Research-status Report
  • [Presentation] Proliferative and hypertrophic defects contributes to LMNA associated dilated cardiomyopathy2016

    • Author(s)
      Kenji Onoue
    • Organizer
      International Society for Heart Research XXII World Congress
    • Place of Presentation
      BuenosAires
    • Year and Date
      2016-04-18
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Proliferative and hypertrophic defects contributes to LMNA associated dilated cardiomyopathy2016

    • Author(s)
      尾上健児
    • Organizer
      ISHR XXII World Congress
    • Place of Presentation
      ブエノスアイレス
    • Year and Date
      2016-04-18
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] The influence of androgenic hormone on congestive heart failure, through analyses of lamin associated dilated cardiomyopathy2015

    • Author(s)
      尾上健児
    • Organizer
      第32回国際心臓研究学会日本部会
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-10
    • Related Report
      2015 Research-status Report
  • [Remarks] 奈良県立医大第1内科

    • URL

      http://www.naramed-u.ac.jp/~1int/index.html

    • Related Report
      2016 Annual Research Report

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Published: 2014-04-04   Modified: 2022-02-16  

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