Novel cardiovascular drug discovery based on the cardiac-MLCK signalings
| Project/Area Number |
26461138
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
Osamu Seguchi 国立研究開発法人国立循環器病研究センター, 病院, 医師 (60570869)
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| Co-Investigator(Renkei-kenkyūsha) |
Kuroda Kensuke 国立研究開発法人国立循環器病研究センター, 移植医療部, 医師
Kitakaze Masafumi 国立研究開発法人国立循環器病研究センター, 臨床研究センター, 部長
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| Research Collaborator |
Minamino Naoto 国立研究開発法人国立循環器病研究センター, 創薬オミックス解析センター, 部長
Nishigori Mitsuhiro 国立研究開発法人国立循環器病研究センター, 創薬オミックス解析センター, 特任研究員
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 心不全 / 創薬 |
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| Outline of Final Research Achievements |
A cardia-MLCK is the cardiac specific molecules that has been discovered by the author of this reseach. A cardiac-MLCK is the kinase that has been reported to play a key role in reconstitution of sarcomere structures and myocardial contraction. The purpose of this reserach is to discover the novel drugs for cardiovascular systems based on the peptides that has specifically bound to cardiac-MLCK. Now we are evaluating the biological effect of these peptides on cardiac-MLCK signaling in both in vivo and in vitro settings.
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Report
(4 results)
Research Products
(2 results)
