| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Previous reports represented that the obesity has a close relations to the atherosclerotic diseases. Howevere, there are a lot of missing link in the molecular mechanisms. Here, we report that the adipocyte progenitor cells could have the unknown role in adipose tissue dysfunction. Normally, the obesity stress induces adipose progenitor cell hyperplasia. Under the stress, the adipose progenitor cells will differentiate into new cell clusters, which will produce inflammatory cytokines and have completely different gene expression profiles. We named these cells as adipocyte progenitor derived pro-inflammatory cells (APDP cells), and this APDP cell has a unique identity to induce angiogenesis in adipose tissue. We thought this unique identity should be the adaptation to the over lipid stress. And also we could say that the failure of the adaptation to the stress is the cause of inflammatory phenotype in adipose tissue.
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