The role of omentin in the vascualr disease

• Project/Area Number: 26461143
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Nagoya University
• Principal Investigator: Shibata Rei 名古屋大学, 医学系研究科, 寄附講座准教授 (70343689)
• Co-Investigator(Kenkyū-buntansha): 大内 乗有 名古屋大学, 医学系研究科, 寄附講座教授 (00595514) ; 室原 豊明 名古屋大学, 医学系研究科, 教授 (90299503)
• Co-Investigator(Renkei-kenkyūsha): MUROHARA TOYOAKI 名古屋大学, 大学院医学系研究科, 教授 (90299503)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: オメンチン / 動脈硬化 / 血管リモデリング

Outline of Final Research Achievements

Adipose tissue functions as an endocrine organ by secreting adipokines that can directly affect nearby or remote organs. Omentin is an adipokine whose concentration is down-regulated in subjects with obesity-related disorders. Low levels of circulating omentin appear to associate with the increased prevalence of obesity-linked vascular diseases including atherosclerosis. In our study, we have shown that omentin exerts beneficial effects on the vascular disease by directly acting on the component cells in the blood vessel. The therapeutic approaches aimed at increasing circulating omentin levels could be valuable for prevention or treatment of cardiovascular diseases.

Research Products

• [Journal Article] The role of adipokines in cardiovascular disease. (2017)
  • Author(s): Shibata R, Ouchi N, Ohashi K, Murohara T.
  • Journal Title: J Cardiol. Volume: 17 Issue: 4 Pages: 30060-6
  • DOI: 10.1016/j.jjcc.2017.02.006
  • NAID: 130006887060
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] C1q/TNF-related protein 1 prevents neointimal formation after arterial injury. (2017)
  • Author(s): Kanemura N, Shibata R, Ohashi K, Ogawa H, Hiramatsu-Ito M, Enomoto T, Yuasa D, Ito M, Hayakawa S, Otaka N, Murohara T, Ouchi N.
  • Journal Title: Atherosclerosis. Volume: 257 Pages: 138-145
  • DOI: 10.1016/j.atherosclerosis.2017.01.014
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Increased expression of the adipocytokine omentin in the epicardial adipose tissue of coronary artery disease patients. (2016)
  • Author(s): Harada K, Shibata R, Ouchi N, Tokuda Y, Funakubo H, Suzuki M, Kataoka T, Nagao T, Okumura S, Shinoda N, Kato B, Sakai S, Kato M, Marui N, Ishii H, Amano T, Matsubara T, Murohara T.
  • Journal Title: Atherosclerosis. Volume: 251 Pages: 299-304
  • DOI: 10.1016/j.atherosclerosis.2016.07.003
  • Peer Reviewed / Open Access
• [Journal Article] Omentin attenuates atherosclerotic lesion formation in apolipoprotein E-deficient mice. (2016)
  • Author(s): Hiramatsu-Ito M, Shibata R, Ohashi K, Uemura Y, Kanemura N, Kambara T, Enomoto T, Yuasa D, Matsuo K, Ito M, Hayakawa S, Ogawa H, Otaka N, Kihara S, Murohara T and Ouchi N.
  • Journal Title: Cardiovasc Res. Volume: 110 Issue: 1 Pages: 107-117
  • DOI: 10.1093/cvr/cvv282
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Omentin functions to attenuate cardiac hypertrophic response. (2015)
  • Author(s): Matsuo K, Shibata R, Ohashi K, Kambara T, Uemura Y, Hiramatsu-Ito M, Enomoto T, Yuasa D, Joki Y, Ito M, Hayakawa S, Ogawa H, Kihara S, Murohara T, Ouchi N.
  • Journal Title: J Mol Cell Cardiol. Volume: 79 Pages: 195-202
  • DOI: 10.1016/j.yjmcc.2014.11.019
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Adipose-derived protein omentin prevents neointimal formation after arterial injury. (2015)
  • Author(s): Uemura Y, Shibata R, Kanemura N, Ohashi K, Kambara T, Hiramatsu-Ito M, Enomoto T, Yuasa D, Joki Y, Matsuo K, Ito M, Hayakawa S, Ogawa H, Murohara T, Ouchi N.
  • Journal Title: FASEB J. Volume: 29 Issue: 1 Pages: 141-51
  • DOI: 10.1096/fj.14-258129
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Adiponectin ameliorates endotoxin-induced acute cardiac injury. (2014)
  • Author(s): Watanabe Y, Shibata R, Ouchi N, Kambara T, Ohashi K, Jie L, Inoue Y, Murohara T, Komori K.
  • Journal Title: Biomed Res Int. Volume: 2014 Pages: 382035-382035
  • DOI: 10.1155/2014/382035
  • Peer Reviewed / Open Access
• [Journal Article] Vildagliptin stimulates endothelial cell network formation and ischemia-induced revascularization via an endothelial nitric oxide synthase-dependent mechanism (2014)
  • Author(s): Ishii M, Shibata R, Kondo K, Kambara T, Shimizu Y, Tanigawa T, Bando YK, Nishimura M, Ouchi N, Murohara T.
  • Journal Title: J Biol Chem Volume: 289 Issue: 39 Pages: 27235-45
  • DOI: 10.1074/jbc.m114.557835
  • Peer Reviewed / Open Access
• [Journal Article] Multilayered adipose-derived regenerative cell sheets created by a novel magnetic tissue engineering method for myocardial infarction. (2014)
  • Author(s): Ishii M, Shibata R, Shimizu Y, Yamamoto T, Kondo K, Inoue Y, Ouchi N, Tanigawa T, Kanemura N, Ito A, Honda H, Murohara T.
  • Journal Title: Int J Cardiol. Volume: 175 Issue: 3 Pages: 545-553
  • DOI: 10.1016/j.ijcard.2014.06.034
  • Peer Reviewed / Open Access
• [Presentation] Role of C1q/TNF-related proteins as adipokines in cardiovascular disease (2016)
  • Author(s): Rei Shibata
  • Organizer: CVMW 2016 心血管代謝週間
  • Place of Presentation: 東京国際フォーラム（東京都千代田区）
  • Year and Date: 2016-12-16
  • Invited
• [Presentation] 心血管病における再生医療 -脂肪が下肢切断を救う- (2016)
  • Author(s): 柴田玲
  • Organizer: 第23回日本心血管インターベンション治療学会(CVIT)中国・四国地方会
  • Place of Presentation: 岡山コンベンションセンター（岡山市北区）
  • Year and Date: 2016-09-03
  • Invited
• [Presentation] Therapeutic angiogenesis for critical limb ischemia by implantation of adipose-derived regenerative cells (2016)
  • Author(s): Rei Shibata
  • Organizer: The 10th Oriental Congress of Cardiology 2016
  • Place of Presentation: 上海（中国）
  • Year and Date: 2016-05-27
  • Int'l Joint Research / Invited
• [Presentation] ヒト歯髄幹細胞無血清培養上清を用いた 虚血性心疾患治療の開発 (2015)
  • Author(s): 柴田玲、山本郎仁、山口聡、山本憲幸、室原豊明
  • Organizer: 第14回日本再生医療学会総会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2015-03-21
  • Invited
• [Presentation] オメンチンの心血管病における役割 (2015)
  • Author(s): 柴田 玲 大内乗有 室原豊明
  • Organizer: 第88回日本薬理学会年会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2015-03-18
  • Invited
• [Presentation] Therapeutic angiogenesis by adipose-derived regenerative cells (2014)
  • Author(s): Rei Shibata, Kazuhisa Kondo, Satoshi Shintani, Toyoaki Murohara
  • Organizer: The 31st Annual Meeting of the International Society for Heart Research Japanese Section
  • Place of Presentation: ウインク愛知（愛知県名古屋市）
  • Year and Date: 2014-11-28
  • Invited
• [Presentation] 脂肪組織由来間葉系前駆細胞を用いた 血管新生療法の開発 (2014)
  • Author(s): 柴田玲 近藤和久 新谷理 室原豊明
  • Organizer: 第18回日本心血管内分泌代謝学会学術総会
  • Place of Presentation: 横浜市開港記念会館（神奈川県横浜市）
  • Year and Date: 2014-11-21
  • Invited
• [Presentation] 炎症と再生におけるアディポサイトカインの役割 (2014)
  • Author(s): 柴田 玲、室原豊明
  • Organizer: 第14回日本抗加齢医学会総会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2014-06-06
  • Invited
• [Patent(Industrial Property Rights)] 膵液瘻の予防及び治療 (2014)
  • Inventor(s): 國料俊男、山本徳則、柴田玲
  • Industrial Property Rights Holder: 名古屋大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2014-07-17