• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Elucidation of mechiansms underlying Nox4-mediated enhancement of hypoxic responses in endothelial cells

Research Project

Project/Area Number 26461145
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionKyushu University

Principal Investigator

Ago Tetsuro  九州大学, 大学病院, 講師 (30514202)

Research Collaborator KITAZONO TAKANARI  九州大学, 大学院・医学研究院・病態機能内科学, 教授 (70284487)
KURODA JUNNYA  九州大学, 大学病院・腎高血圧脳血管内科, 助教 (70614858)
WAKISAKI YOSHINOBU  九州大学, 大学病院・腎高血圧脳血管内科, 助教 (50631694)
TACHIBANA MASAKI  九州大学, 大学院・医学研究院・病態機能内科学, 大学院生
YOSHIKAWA YOJI  九州大学, 大学院・医学研究院・病態機能内科学, 大学院生
KOMORI MOTOHIRO  九州大学, 大学院・医学研究院・病態機能内科学, 大学院生
MAKIHARA NORIKO  九州大学, 大学院・医学研究院・病態機能内科学, 大学院生
NISHIMURA ATARU  九州大学, 大学院・医学研究院・病態機能内科学, 大学院生
NAKAMURA KUNIYUKI  九州大学, 大学院・医学研究院・病態機能内科学
SADOSHIMA JUNICHI  Rutgers New Jersey Medical School, Department of Cell Biology and Molecular Medicine, Professor
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsNADPH oxidase / 活性酸素種 / 内皮細胞 / 周皮細胞 / 低酸素 / 脳梗塞 / 動脈硬化 / 下肢虚血 / NADPH oxidase Nox4 / ミトコンドリア / Nox4 / 血管内皮細胞 / 血管周皮細胞 / 脳虚血 / HIF-1 / 炎症
Outline of Final Research Achievements

Stroke, myocardial infarction, and arteriosclerosis obliterans are representative adult vascular diseases to be overcome. Although there are many sizes of vascular vessels, endothelial cells cover intraluminal sides of any vascular vessels. Because there is abundant molecular oxygen within the arteries, reactive oxygen species (ROS) can be easily produced in endothelial cells and be associated with the development and progression of the vascular diseases. Thus, it is indispensable for overcoming of the vascular diseases to understand well the mechanisms by which ROS are produced and regulated in endothelial cells. In the present study, I elucidate ischemic/hypoxic responses and pathological roles mediated by ROS-producing Nox4 in endothelial cells.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (20 results)

All 2017 2016 2015 2014 Other

All Journal Article (9 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 9 results,  Acknowledgement Compliant: 5 results,  Open Access: 4 results) Presentation (10 results) (of which Invited: 9 results) Remarks (1 results)

  • [Journal Article] Early reperfusion after brain ischemia has beneficial effects beyond rescuing neurons2017

    • Author(s)
      Tachibana M, Ago T, Wakisaka Y, Kuroda J, Shijo M, Yoshikawa Y, Komori M, Nishimura A, Makihara N, Nakamura K, Kitazono T
    • Journal Title

      Stroke

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Possible involvement of basic FGF in the upregulation of PDGFRβ in pericytes after ischemic stroke2016

    • Author(s)
      Nakamura K, Arimura K, Nishimura A, Tachibana M, Yoshikawa Y, Makihara N, Wakisaka Y, Kuroda J, Kamouchi M, Ooboshi H, Kitazono T, Ago T
    • Journal Title

      Brain Research

      Volume: 1630 Pages: 98-108

    • DOI

      10.1016/j.brainres.2015.11.003

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Pro-atherogenic role of smooth muscle Nox4-based NADPH oxidase2016

    • Author(s)
      Tong X, Ago T, et al.
    • Journal Title

      Journal of Molecular and Cellular Cardiology

      Volume: 92 Pages: 30-40

    • DOI

      10.1016/j.yjmcc.2016.01.020

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Detrimental role of pericyte Nox4 in the acute phase of brain ischemia2015

    • Author(s)
      Nishimura A, Ago T, Kuroda J, Arimura K, Tachibana M, Nakamura K, Wakisaka Y, Sadoshima J, Iihara K, Kitazono T
    • Journal Title

      Journal of Cerebral Blood Flow and Metabolism

      Volume: - Issue: 6 Pages: 1143-1154

    • DOI

      10.1177/0271678x15606456

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Role of smooth muscle Nox4-based NADPH oxidase in neointimal hyperplasia2015

    • Author(s)
      Tong X, Ago T, et al.
    • Journal Title

      Journal of Molecular and Cellular Cardiology

      Volume: 89 Pages: 185-194

    • DOI

      10.1016/j.yjmcc.2015.11.013

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Involvement of platelet-derived growth factor receptor β in fibrosis through extracellular matrix protein production after ischemic stroke2015

    • Author(s)
      Makihara N, Arimura K, Ago T, Tachibana M, Nishimura A, Nakamura K, Matsuo R, Wakisaka Y, Kuroda J, Sugimori H, Kamouchi M, Kitazono T
    • Journal Title

      Experimental Neurology

      Volume: 264 Pages: 127-134

    • DOI

      10.1016/j.expneurol.2014.12.007

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Nox4 is a major source of superoxide production in human brain pericytes2014

    • Author(s)
      Kuroda J, Ago T, Nishimura A, Nakamura K, Matsuo R, Wakisaka Y, Kamouchi M, KItazono T
    • Journal Title

      Journal of vascular research

      Volume: 51 Issue: 6 Pages: 429-438

    • DOI

      10.1159/000369930

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Both hydrogen peroxide and transforming growth factor beta 1 contribute to endothelial Nox4 mediated angiogenesis in endothelial Nox4 transgenic mouse lines2014

    • Author(s)
      Chen L, Xiao J, Kuroda J, Ago T, et al.
    • Journal Title

      Biochimica et biophysica acta

      Volume: 1842 Issue: 12 Pages: 2489-99

    • DOI

      10.1016/j.bbadis.2014.10.007

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] 脳ペリサイトの重要性と脳血管障害における役割2014

    • Author(s)
      吾郷哲朗,北園孝成
    • Journal Title

      福岡医学雑誌

      Volume: 105 Pages: 125-130

    • NAID

      120005475545

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 脳梗塞後の組織修復における再灌流治療の有用性に関する基礎的研究2017

    • Author(s)
      吾郷哲朗,北園孝成
    • Organizer
      第42回日本脳卒中学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Role and significance of pericyte in cerebrovascular diseases2017

    • Author(s)
      吾郷哲朗,北園孝成
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      浜松
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 脳虚血とNADPH oxidase family2016

    • Author(s)
      吾郷哲朗
    • Organizer
      Vas-Cog Japan 2016
    • Place of Presentation
      金沢
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Neurovascular Unitからみた脳血管障害2016

    • Author(s)
      吾郷哲朗,北園孝成
    • Organizer
      第20回眼創傷治癒研究会
    • Place of Presentation
      福岡
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 臨床現場のアンメット・ニーズ 脳血管障害2015

    • Author(s)
      吾郷哲朗
    • Organizer
      第31回日本DDS学会学学術集会
    • Place of Presentation
      東京
    • Year and Date
      2015-07-03
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 脳虚血病態におけるペリサイトの役割2015

    • Author(s)
      吾郷哲朗
    • Organizer
      第56回日本神経学会学術大会
    • Place of Presentation
      新潟
    • Year and Date
      2015-05-21
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 活性酸素種産生酵素 Nox4 による内皮・周皮細胞の分子制御とその意義2014

    • Author(s)
      吾郷哲朗
    • Organizer
      脳心血管抗加齢研究会2014
    • Place of Presentation
      大阪
    • Year and Date
      2014-12-06
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 心・脳血管病から見える活性酸素種産生酵素Nox4の功罪2014

    • Author(s)
      吾郷哲朗
    • Organizer
      第31回臨床フリーラジカル会議
    • Place of Presentation
      京都
    • Year and Date
      2014-12-05
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 脳虚血により微小血管細胞に発現誘導されるNox4の意義2014

    • Author(s)
      吾郷哲朗
    • Organizer
      第26回 日本脳循環代謝学会総会
    • Place of Presentation
      岡山
    • Year and Date
      2014-11-21
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Roles of pericyte NADPH oxidase 4 in acute brain ischemia2014

    • Author(s)
      Nishimura A, Ago T, et al.
    • Organizer
      Neuroscience 2014
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2014-11-17
    • Related Report
      2014 Research-status Report
  • [Remarks] 九州大学大学院 医学研究院 病態機能内科学 脳循環研究室

    • URL

      http://www.stroke.med.kyushu-u.ac.jp

    • Related Report
      2016 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi