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The Role of Hemodynamic Stress in the Development/Maintenance of Occlusive Vascular Lesions in Severe Pulmonary Hypertension

Research Project

Project/Area Number 26461146
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionKyushu University

Principal Investigator

Abe Kohtaro  九州大学, 大学病院, 助教 (20588107)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords肺高血圧症 / 閉塞性病変 / 炎症 / 血行動態ストレス / 閉塞性肺血管病変
Outline of Final Research Achievements

An important pathogenic mechanism in the development of idiopathic pulmonary arterial hypertension is hypothesized to be a cancer-like cellular proliferation independent of hemodynamics. However, because the vascular lesions are inseparably coupled with hemodynamic stress, the fate of the lesions is unknown when hemodynamic stress is eliminated.
Our results indicate that hemodynamic stress is prerequisite to the development and progression of occlusive neointimal lesions in this rat model of severe pulmonary hypertension. We conclude that perivascular inflammation and occlusive neointimal arteriopathy are driven by hemodynamic stress.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (74 results)

All 2017 2016 2015 2014

All Journal Article (26 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 15 results,  Acknowledgement Compliant: 9 results,  Open Access: 2 results) Presentation (48 results) (of which Int'l Joint Research: 5 results,  Invited: 16 results)

  • [Journal Article] nergy efficiency and pulmonary artery flow after balloon pulmonary angioplasty for inoperable, chronic thromboembolic pulmonary hypertension: Analysis by phase-contrast MRI2017

    • Author(s)
      Michinobu Nagao, Yuzo Yamasaki et al.
    • Journal Title

      European Journal of Radiology

      Volume: 87 Pages: 99-104

    • DOI

      10.1016/j.ejrad.2016.12.015

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hemodynamic unloading reserses occlusive vascular lesions in severe pulmonary hypertension.2016

    • Author(s)
      Abe K, Shinoda M., Tanaka M., Kuwabara Y., Yoshida K., Hirooka Y., McMurtry IF., Sunagawa K.
    • Journal Title

      Cardiovasc Res.

      Volume: 111 Issue: 1 Pages: 16-25

    • DOI

      10.1093/cvr/cvw070

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Pulmonary arterial hypertension associated with hereditary hemorrhagic telangiectasia successfully treated with sildenafil.2016

    • Author(s)
      Miyake R, Fujino T, Abe K, Hosokawa K, Ohtani K, Morisaki H, Yamada O, Higo T, Ide T.
    • Journal Title

      Int J Cardiol

      Volume: 31 Pages: 275-276

    • DOI

      10.1016/j.ijcard.2016.03.211

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Optical Frequency Domain Imaging of Covered Stent-Graft for Pulmonary Artery Pseudoaneurysm after Balloon Pulmonary Angioplasty.2016

    • Author(s)
      Horimoto K, Abe K, Ohtani K, Takahara Y , Hosokawa K, Oi K, Mukai Y, Kubo T, Matoba T, Tsutsui H.
    • Journal Title

      JACC Cardiovasc Interv.

      Volume: 9 Issue: 21 Pages: 31346-2

    • DOI

      10.1016/j.jcin.2016.08.022

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Haemodynamic unloading reverses occlusive vascular lesions in severe pulmonary hypertension.2016

    • Author(s)
      Abe K, Shinoda M, Tanaka M, Kuwabara Y, Yoshida K, Hirooka Y, McMurtry IF, Oka M, Sunagawa K.
    • Journal Title

      Cardiovasc Res

      Volume: 印刷中

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 肺高血圧症動物モデルからの知見.2016

    • Author(s)
      阿部弘太郎
    • Journal Title

      臨床雑誌内科

      Volume: 117 Pages: 479-483

    • Related Report
      2015 Research-status Report
  • [Journal Article] 肺高血圧症.2016

    • Author(s)
      阿部弘太郎
    • Journal Title

      ガイドライン外来診療2016

      Pages: 383-388

    • Related Report
      2015 Research-status Report
  • [Journal Article] Balloon pulmonary angioplasty-related complications and therapeutic strategy in patients with chronic thromboembolic pulmonary hypertension.2015

    • Author(s)
      Hosokawa K, Abe K, Oi K, Mukai Y, Hirooka Y, Sunagawa K.
    • Journal Title

      Int J Cardiol

      Volume: 197 Pages: 224-226

    • DOI

      10.1016/j.ijcard.2015.06.075

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Reversal of diffuse patchy pattern in lung perfusion scan in a case of severe pulmonary arterial hypertension.2015

    • Author(s)
      Kodama Y, Abe K, Hosokawa K, Ohtani K, Nagao M, Hirooka Y, Sunagawa K.
    • Journal Title

      Heart Lung

      Volume: 44 Issue: 5 Pages: 451-452

    • DOI

      10.1016/j.hrtlng.2015.06.005

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Lipid nanoparticle delivery of a microRNA-145 inhibitor improves experimental pulmonary hypertension.2015

    • Author(s)
      McLendon JM, Joshi SR, Sparks J, Matar M, Fewell JG, Abe K, Oka M, McMurtry IF, Gerthoffer WT.
    • Journal Title

      J Control Release

      Volume: 13 Pages: 67-75

    • DOI

      10.1016/j.jconrel.2015.05.261

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 治療薬の現状 e.多剤併用療法のエビデンス.2015

    • Author(s)
      阿部弘太郎
    • Journal Title

      Heart View

      Volume: 19 Pages: 766-770

    • Related Report
      2015 Research-status Report
  • [Journal Article] NOを介する治療.2015

    • Author(s)
      田中真理子、阿部弘太郎.
    • Journal Title

      診断と治療のABC

      Volume: 104 Pages: 127-133

    • Related Report
      2015 Research-status Report
  • [Journal Article] 今後の実用化が期待される肺高血圧症治療薬について教えてください.2015

    • Author(s)
      阿部弘太郎
    • Journal Title

      ~早期診断・治療のための~ 肺高血圧症Q&A

      Pages: 193-196

    • Related Report
      2015 Research-status Report
  • [Journal Article] 肺高血圧症治療における分子標的薬の可能性.2015

    • Author(s)
      藤野剛雄、阿部弘太郎.
    • Journal Title

      Medical Practice

      Volume: 32 Pages: 1997-2000

    • Related Report
      2015 Research-status Report
  • [Journal Article] 肺高血圧症モデル動物を用いた基礎研究の知見.2015

    • Author(s)
      阿部弘太郎
    • Journal Title

      血管

      Volume: 38 Pages: 145-154

    • Related Report
      2015 Research-status Report
  • [Journal Article] 1.Prediction of adverse cardiac events in dilated cardiomyopathy using cardiac T2* MRI and MIBG scintigraphy.2015

    • Author(s)
      Michinobu Nagao, Shingo Baba, Masato Yonezawa, Yuzo Yamasaki, Takeshi Kamitani, Takuro Isoda, Satoshi Kawanami, Yasuhiro Maruoka, Yoshiyuki Kitamura, Kohtaro Abe, Taiki Higo, Kenji Sunagawa, Hiroshi Honda
    • Journal Title

      International Journal of Cardiovascular Imaging

      Volume: 31 Issue: 2 Pages: 399-407

    • DOI

      10.1007/s10554-014-0562-1

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Negative acute hemodynamic response to balloon pulmonary angioplasty does not predicate the long-term outcome in patients with chronic thromboembolic pulmonary hypertension.2015

    • Author(s)
      Hosokawa K, Abe K, Oi K, Mukai Y, Hirooka Y, Sunagawa K
    • Journal Title

      Int J Cardiol

      Volume: 188 Pages: 81-83

    • DOI

      10.1016/j.ijcard.2015.04.025

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] 肺高血圧症2015

    • Author(s)
      阿部弘太郎
    • Journal Title

      呼吸と循環

      Volume: 63 Pages: 323-328

    • Related Report
      2014 Research-status Report
  • [Journal Article] 肺高血圧症に伴う右心機能の診断2015

    • Author(s)
      吉田賢明、阿部弘太郎、朔啓太、砂川賢二
    • Journal Title

      Cardiac Practice

      Volume: 26 Pages: 27-29

    • Related Report
      2014 Research-status Report
  • [Journal Article] 肺高血圧症の肺動脈リバースリモデリングは可能か?2015

    • Author(s)
      阿部弘太郎
    • Journal Title

      肺高血圧症診療マニュアル

      Volume: 印刷中

    • Related Report
      2014 Research-status Report
  • [Journal Article] A novel strategy to selectively enhance pulmonary drug efficacy in pulmonary arterial hypertension.2014

    • Author(s)
      Toba M, Alzoubi A, O'Neill K, Abe K, Urakami T, Komatsu M, Alvarez D, Järvinen TA, Mann D, Ruoslahti E, McMurtry IF, Oka M.
    • Journal Title

      Am J Pathol.

      Volume: 184 Issue: 2 Pages: 369-375

    • DOI

      10.1016/j.ajpath.2013.10.008

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Temporal hemodynamic and histological progress in Sugen5416/hypoxia/normoxia-exposed pulmonary arterial hypertensive rats.2014

    • Author(s)
      Toba M, Alzoubi A, O'Neill KD, Gairhe S, Matsumoto Y, Oshima K, Abe K, Oka M, McMurtry IF.
    • Journal Title

      Am J Physiol Heart Circ Physiol.

      Volume: 306 Issue: 2 Pages: 253-250

    • DOI

      10.1152/ajpheart.00728.2013

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Quantification of myocardial iron deficiency in nonischemic heart failure by cardiac t2* magnetic resonance imaging.2014

    • Author(s)
      Nagao M, Matsuo Y, Kamitani T, Yonezawa M, Yamasaki Y, Kawanami S, Abe K, Mukai Y, Higo T, Yabuuchi H, Takemura A, Yoshiura T, Sunagawa K, Honda H.
    • Journal Title

      Am J Cardiol.

      Volume: 113 Issue: 6 Pages: 1024-1030

    • DOI

      10.1016/j.amjcard.2013.11.061

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Novel dual endothelin receptor antagonist macitentan reverses severe pulmonary arterial hypertension in rats.2014

    • Author(s)
      Kunita-Takanezawa M, Abe K, Hirooka Y, Kuwabara Y, Hirano K, Oka M, Sunagawa K.
    • Journal Title

      J Cardiovasc Pharmacol.

      Volume: 64 Issue: 5 Pages: 473-80

    • DOI

      10.1097/fjc.0000000000000141

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Interventricular dyssynchrony using tagging magnetic resonance imaging predicts right ventricular dysfunction in adult congenital heart disease.2014

    • Author(s)
      Michinobu Nagao, Yuzo Yamasaki, Masato Yonezawa, Yoshio Matsuo, Takeshi Kamitani, Kenichiro Yamamura, Ichiro Sakamoto, Kohtaro Abe, Satoshi Kawanami, Hiroshi Honda.
    • Journal Title

      Congenital Heart Disease

      Volume: online Issue: 3 Pages: 1-10

    • DOI

      10.1111/chd.12217

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 今後期待される肺高血圧症治療薬の展望2014

    • Author(s)
      阿部弘太郎、廣岡良隆、砂川賢二
    • Journal Title

      呼吸器内科

      Volume: 26 Pages: 300-304

    • NAID

      40020251438

    • Related Report
      2014 Research-status Report
  • [Presentation] Hemodynamic Unloading Reverses Occlusive Vascular Lesions in Severe PAH by inhibiting perivascular inflammation.2017

    • Author(s)
      Abe K, Oka M, Tsutsui H.
    • Organizer
      131.第81回日本循環器学会総会
    • Place of Presentation
      金沢
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] 新規PAHモデルにおける閉塞性肺血管病変進展・維持に関する研究2016

    • Author(s)
      阿部 弘太郎、岡正彦、篠田雅子、田中真理子、桑原志実、吉田賢明、廣岡良隆、砂川賢二、筒井裕之
    • Organizer
      第1回日本肺高血圧・肺循環学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2016-09-30
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 血行動態ストレス軽減を標的としたPAH治療機序の解明2016

    • Author(s)
      阿部 弘太郎
    • Organizer
      第64回日本心臓病学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2016-09-23
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] PAHに特徴的な閉塞性血管病変の進展機序.2016

    • Author(s)
      阿部弘太郎
    • Organizer
      第56回日本呼吸器学会学術講演会
    • Place of Presentation
      国立京都国際会館(京都市左京区)
    • Year and Date
      2016-04-08
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Hemodynamic Unloading Reverses Occlusive Vascular Lesions in Severe Pulmonary Arterial Hypertension.2016

    • Author(s)
      Abe K, Oka M, Shinoda M, Kuwabara Y, Tanaka M, Yoshida K, Hirooka Y, Sunagawa K.
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      仙台国際センター(仙台市青葉区)
    • Year and Date
      2016-03-20
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] NF-κB-Mediated Inflammation Plays a Key Role in Deteriorating RV Function in Pulmonary Artery Banding Rats.2016

    • Author(s)
      Yoshida K, Abe K, Tanaka M, Shinoda M, Kuwabara Y, Saku K, Hirooka Y, Oka M, Sunagawa K.
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      仙台国際センター(仙台市青葉区)
    • Year and Date
      2016-03-20
    • Related Report
      2015 Research-status Report
  • [Presentation] Critical Protective Role of Endogenous Nitric Oxide in Severe Pulmonary Arterial Hypertension in Rats.2016

    • Author(s)
      Tanaka, M, Abe K, Oka M,Schwenke DO, Shirai M, Kuwahira I, Hirooka Y, Hoka S, Sunagawa K.
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      せんだい青葉山交流広場(仙台市青葉区)
    • Year and Date
      2016-03-20
    • Related Report
      2015 Research-status Report
  • [Presentation] Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension Improves Right Ventricular-Pulmonary Arterial Coupling without Changing Right Ventricular Contractility.2016

    • Author(s)
      Sakamoto T, Abe K, Hosokawa K, Ohi K, Mukai Y, Horimoto K, Ohtani K, Yamasaki Y, Nagao M, Higo T, Ide T, Sunagawa K.
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      仙台国際センター(仙台市青葉区)
    • Year and Date
      2016-03-20
    • Related Report
      2015 Research-status Report
  • [Presentation] Assessment of Flow Energy after Balloon Pulmonary Angioplasty in Chronic Thromboembolic Pulmonary Hypertension Using Phase-contrast MRI.2016

    • Author(s)
      Nagao M, Yamasaki Y, Abe K, Hosokawa K, Ohi K, Mukai Y, Kawanami S, Kamitani T, Yamanouchi T, Honda H.
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      せんだい青葉山交流広場(仙台市青葉区)
    • Year and Date
      2016-03-19
    • Related Report
      2015 Research-status Report
  • [Presentation] Balloon Pulmonary Angioplasty Improves not only Pulmonary Arterial Resistance but also Compliance in Patients with Chronic Thromboembolic Pulmonary Hypertension.2016

    • Author(s)
      Horimoto K, Abe K, Hosokawa K, Ohi K, Mukai Y, Hiasa K, Ohtani K, Higo T, Ide T, Hirooka Y, Sunagawa K.
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      せんだい青葉山交流広場(仙台市青葉区)
    • Year and Date
      2016-03-19
    • Related Report
      2015 Research-status Report
  • [Presentation] Transiting from IV Epoprostenol to Treprostinil Increases Platelet Counts in Patients with Severe Pulmonary Arterial Hypertension.2016

    • Author(s)
      Ishikawa T, Abe K, Sakamoto T, Sezutsu Y, Sakemi T, Hosokawa K, Ohtani K, Ide T, Higo T.
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      せんだい青葉山交流広場(仙台市青葉区)
    • Year and Date
      2016-03-19
    • Related Report
      2015 Research-status Report
  • [Presentation] Balloon Pulmonary Angioplasty Ameliorates Non-BPA Sided Pulmonary Vascular Resistance in Patients with Chronic Thromboembolic Pulmonary Hypertension.2016

    • Author(s)
      Hosokawa K, Abe K, Ohi K, Mukai Y, Yamasaki Y, Nagao M, Hirooka Y, Sunagawa K.
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      仙台国際センター(仙台市青葉区)
    • Year and Date
      2016-03-18
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Increased Expression of Thrombin Receptor, PAR1 is a New Therapeutic Target for Pulmonary Hypertension.2016

    • Author(s)
      Kuwabara Y, Abe K, Hirano M, Hirooka Y, Sunagawa K, Hirano K.
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      仙台国際センター(仙台市青葉区)
    • Year and Date
      2016-03-18
    • Related Report
      2015 Research-status Report
  • [Presentation] 重度の下腿浮腫から緊満性の皮膚割創をきたし、出血性ショックに陥った重症肺動脈性肺高血圧症の一例.2016

    • Author(s)
      伊藤美咲、石村徳彦、堀智恵、瀬筒康弘、阿部弘太郎、大谷規彰、日浅謙一、肥後太基、井手友美.
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      せんだい青葉山交流広場(仙台市青葉区)
    • Year and Date
      2016-03-18
    • Related Report
      2015 Research-status Report
  • [Presentation] 心臓リハビリテーションの長期継続が可能であったEisenmenger症候群の一症例.2016

    • Author(s)
      樋口妙、肥後太基、阿部弘太郎、井手友美、藤吉大輔、宮里幸、永富祐太.
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      せんだい青葉山交流広場(仙台市青葉区)
    • Year and Date
      2016-03-18
    • Related Report
      2015 Research-status Report
  • [Presentation] Proteinase-activated Receptor 1 Antagonist Inhibited the Progression of Monocrotaline Induced Pulmonary Hypertension in Rats.2015

    • Author(s)
      Kuwabara Y, Abe K, Hirano M, Hirano K, Sunagawa K.
    • Organizer
      Annual Scientific Meeting of the American Heart Association 2015
    • Place of Presentation
      オーランド(米国)
    • Year and Date
      2015-11-10
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Critical Protective Role of Endogenous Nitric Oxide in Established Severe Pulmonary Arterial Hypertension in Rats.2015

    • Author(s)
      Tanaka M, Abe K, Oka M, Schwenke DO, Shirai M, Kuwahira I, Hirooka Y, Hoka S, Sunagawa K.
    • Organizer
      Annual Scientific Meeting of the American Heart Association 2015
    • Place of Presentation
      オーランド(米国)
    • Year and Date
      2015-11-10
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Pulmonary Artery Banding Induces NF-κB activated Inflammation and Deteriorates RV function.2015

    • Author(s)
      Yoshida K, Abe K, Tanaka M, Shinoda M, Kuwabara Y, Saku K, Hirooka Y, Oka M, Sunagawa K.
    • Organizer
      Annual Scientific Meeting of the American Heart Association 2015
    • Place of Presentation
      オーランド(米国)
    • Year and Date
      2015-11-10
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Balloon Pulmonary Angioplasty Reduces Pulmonary Vascular Resistance in Both BPA and Non-BPA Sided Pulmonary Arteries in Patients with Chronic Thromboembolic Pulmonary Hypertension.2015

    • Author(s)
      Hosokawa K, Abe K,Yamasaki Y, Oi K, Mukai Y, Nagao M, Sunagawa K.
    • Organizer
      Annual Scientific Meeting of the American Heart Association 2015
    • Place of Presentation
      オーランド(米国)
    • Year and Date
      2015-11-08
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 重症PAHの閉塞性血管病変増悪における血行動態ストレスの役割.2015

    • Author(s)
      阿部弘太郎、岡正彦、篠田雅子、田中真理子、桑原志実、吉田賢明、廣岡良隆、砂川賢二.
    • Organizer
      第4回日本肺循環学会/第3回日本肺高血圧学会合同学術集会
    • Place of Presentation
      ステーションコンファレンス東京(東京都千代田区)
    • Year and Date
      2015-10-04
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] バルーン肺動脈拡張術オリエンテーション資料の内容検討.2015

    • Author(s)
      新谷さおり、権藤つかさ、阿部弘太郎、日髙友美、小林稚、細川和也、堀智恵.
    • Organizer
      第4回日本肺循環学会/第3回日本肺高血圧学会合同学術集会
    • Place of Presentation
      ステーションコンファレンス東京(東京都千代田区)
    • Year and Date
      2015-10-04
    • Related Report
      2015 Research-status Report
  • [Presentation] 成人先天性心疾患に伴う右心不全 -心房中隔欠損症-.2015

    • Author(s)
      阿部弘太郎
    • Organizer
      第4回日本肺循環学会/第3回日本肺高血圧学会合同学術集会
    • Place of Presentation
      ステーションコンファレンス東京(東京都千代田区)
    • Year and Date
      2015-10-03
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] トロンビン受容体PAR1拮抗薬は肺高血圧の病態形成を抑制する.2015

    • Author(s)
      桑原志実、阿部弘太郎、平野真弓、廣岡良隆、砂川賢二、平野勝也.
    • Organizer
      第4回日本肺循環学会/第3回日本肺高血圧学会合同学術集会
    • Place of Presentation
      ステーションコンファレンス東京(東京都千代田区)
    • Year and Date
      2015-10-03
    • Related Report
      2015 Research-status Report
  • [Presentation] 圧負荷誘発性右室機能障害におけるNF- κ B を介した炎症の重要性.2015

    • Author(s)
      吉田賢明、阿部弘太郎、田中真理子、篠田雅子、桑原志実、朔啓太、廣岡良隆、岡正彦、砂川賢二.
    • Organizer
      第4回日本肺循環学会/第3回日本肺高血圧学会合同学術集会
    • Place of Presentation
      ステーションコンファレンス東京(東京都千代田区)
    • Year and Date
      2015-10-03
    • Related Report
      2015 Research-status Report
  • [Presentation] Japan PH Registry による本邦のPAH の予後解析.2015

    • Author(s)
      田村雄一、宮田裕章、佐藤徹、松原広己、巽浩一郎、田邉信宏、八尾厚史、阿部 弘太郎、辻野一三、木村弘、JAPHR investigators.
    • Organizer
      第4回日本肺循環学会/第3回日本肺高血圧学会合同学術集会
    • Place of Presentation
      ステーションコンファレンス東京(東京都千代田区)
    • Year and Date
      2015-10-03
    • Related Report
      2015 Research-status Report
  • [Presentation] Hemodynamic Stress is Essential to the Development and Maintenance of Occlusive Vascular Lesions in a Rat Model of Severe PAH.2015

    • Author(s)
      Abe K, Shinoda M, Tanaka M, Kuwabara Y, Yoshida K, McMurtry IF, Hirooka Y, Sunagawa K, Oka M.
    • Organizer
      2015 American Thoracic Society International Conference
    • Place of Presentation
      デンバー(米国)
    • Year and Date
      2015-05-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 肺高血圧症患者に対する心リハ基準と実施時の酸素飽和度2015

    • Author(s)
      宮里幸、阿部弘太郎、樋口妙、藤吉大輔、肥後太基、井手友美、砂川賢二
    • Organizer
      第79回日本循環器学会学術集会
    • Place of Presentation
      グランフロント大阪ナレッジキャピタルカンファレンスルーム
    • Year and Date
      2015-04-26
    • Related Report
      2014 Research-status Report
  • [Presentation] Hemodynamic Stress is Essential to the Development and Maintenance of Occlusive Vascular Lesions in Severe PAH2015

    • Author(s)
      阿部弘太郎
    • Organizer
      第79回日本循環器学会学術集会
    • Place of Presentation
      リーガロイヤルホテル大阪
    • Year and Date
      2015-04-25
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Preclinical Investigation in the Development of Pulmonary Arterial Hypertension2015

    • Author(s)
      阿部弘太郎
    • Organizer
      第79回日本循環器学会学術集会
    • Place of Presentation
      リーガロイヤルホテル大阪
    • Year and Date
      2015-04-25
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Assessment of Pulmonary Valve Using Intracardiac Echocardiography in Patients with Repaired Tetralogy of Fallot2015

    • Author(s)
      坂本一郎、阿部弘太郎、山村健一郎、砂川賢二
    • Organizer
      第79回日本循環器学会学術集会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2015-04-25
    • Related Report
      2014 Research-status Report
  • [Presentation] Increased Activity of Proteinase Activated Receptor1(PAR1) Plays a Key Role in Pathogenesis of Monocrotaline-Induced Pulmonary Hypertension in Rats2015

    • Author(s)
      桑原志実、阿部弘太郎、平野真弓、廣岡良隆、砂川賢二、平野勝也
    • Organizer
      第79回日本循環器学会学術集会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2015-04-24
    • Related Report
      2014 Research-status Report
  • [Presentation] 肺動脈性肺高血圧症の肺血管病変進展における血行動態ストレスの役割2015

    • Author(s)
      阿部弘太郎
    • Organizer
      第44回日本心脈管作動物質学会
    • Place of Presentation
      高松センタービル
    • Year and Date
      2015-02-07
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 九州大学病院における慢性血栓塞栓性肺高血圧症に対する経皮的肺動脈バルーン形成術の成績2014

    • Author(s)
      細川和也、向井靖、阿部弘太郎、大井啓司、砂川賢二
    • Organizer
      第117回日本循環器学会九州地方会
    • Place of Presentation
      沖縄コンベンションセンター
    • Year and Date
      2014-12-06
    • Related Report
      2014 Research-status Report
  • [Presentation] Inhibition of Increased Thrombin Receptor Activity Attenuated Monocrotaline-induced Pulmonary Hypertension in Rats2014

    • Author(s)
      Kuwabara Y, Abe K, Hirano M, Hirooka Y, Hiarano K, Sunagawa K
    • Organizer
      American Heart Association Scientific Sessions 2014
    • Place of Presentation
      Chicago
    • Year and Date
      2014-11-17
    • Related Report
      2014 Research-status Report
  • [Presentation] この20年で急激に進歩した肺高血圧症の治療薬と今後の展望2014

    • Author(s)
      阿部弘太郎
    • Organizer
      第53回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      広島国際会議場
    • Year and Date
      2014-11-08
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] トレプロスチニルによる関節痛にオピオイドが有効であった症例2014

    • Author(s)
      肥後太基、岸拓弥、阿部弘太郎、砂川賢二
    • Organizer
      第2回日本肺高血圧学会・第3回日本肺循環学会合同学術集会
    • Place of Presentation
      大手町サンケイプラザ
    • Year and Date
      2014-10-05
    • Related Report
      2014 Research-status Report
  • [Presentation] 基礎研究を行う上で、どの肺高血圧症疾患モデルが有用か?2014

    • Author(s)
      阿部弘太郎、岡正彦、廣岡良隆、砂川賢二
    • Organizer
      第2回日本肺高血圧学会・第3回日本肺循環学会合同学術集会
    • Place of Presentation
      大手町サンケイプラザ
    • Year and Date
      2014-10-04
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 肺高血圧症におけるトロンビン受容体PAR1の肺動脈収縮作用の亢進2014

    • Author(s)
      桑原志実、阿部弘太郎、平野真弓、廣岡良隆、平野勝也、砂川賢二
    • Organizer
      第2回日本肺高血圧学会・第3回日本肺循環学会合同学術集会
    • Place of Presentation
      大手町サンケイプラザ
    • Year and Date
      2014-10-04
    • Related Report
      2014 Research-status Report
  • [Presentation] 心臓交感神経シンチグラフィーを用いた肺高血圧症の非侵襲的な重症度評価法の確立2014

    • Author(s)
      阿部弘太郎、長尾充展、廣岡良隆、砂川賢二
    • Organizer
      第62回日本心臓病学会学術集会
    • Place of Presentation
      仙台市民会館
    • Year and Date
      2014-09-28
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 多枝病変に対して1セッションでバルーン肺動脈形成術を施行後、急性期に著明な肺高血圧改善を認めた慢性血栓性肺高血圧症の一例2014

    • Author(s)
      香月俊輔、阿部弘太郎、渡邊雅嗣、大井啓司、向井靖、的場哲哉、肥後太基、砂川賢二
    • Organizer
      第21回日本心血管インターベンション治療学会九州・沖縄地方会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2014-08-23
    • Related Report
      2014 Research-status Report
  • [Presentation] 重症肺高血圧症モデル動物におけるRhoキナーゼ阻害薬の肺血管拡張効果の検討2014

    • Author(s)
      阿部弘太郎、鳥羽慶栄、岡正彦
    • Organizer
      第56回日本平滑筋学会総会
    • Place of Presentation
      新横浜プリンスホテル
    • Year and Date
      2014-08-08
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 肺動脈バルーン拡張術で肺高血圧が改善した慢性血栓塞栓性肺高血圧症の1例2014

    • Author(s)
      坂本和生、阿部弘太郎、的場哲哉、大井啓司、向井靖、廣岡良隆、砂川賢二
    • Organizer
      第35回日本循環制御医学会総会
    • Place of Presentation
      九州大学医学部百年講堂
    • Year and Date
      2014-07-05
    • Related Report
      2014 Research-status Report
  • [Presentation] 肺高血圧症と右心機能2014

    • Author(s)
      阿部弘太郎、砂川賢二、廣岡良隆
    • Organizer
      第35回日本循環制御医学会総会
    • Place of Presentation
      九州大学医学部百年講堂
    • Year and Date
      2014-07-04
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] トロンビン受容体拮抗薬はモノクロタリンによる肺高血圧症の誘発を抑制する2014

    • Author(s)
      桑原志実、阿部弘太郎、平野真弓、廣岡良隆、平野勝也、砂川賢二
    • Organizer
      第35回日本循環制御医学会総会
    • Place of Presentation
      九州大学医学部百年講堂
    • Year and Date
      2014-07-04
    • Related Report
      2014 Research-status Report
  • [Presentation] 肺動脈形成術により肺高血圧およびWHO機能分類が劇的に改善した慢性血栓塞栓性肺高血圧症の1例2014

    • Author(s)
      坂本和生、阿部弘太郎、田中和子、的場哲哉、大井啓司、向井靖、廣岡良隆、砂川賢二
    • Organizer
      第116回日本循環器学会九州地方会
    • Place of Presentation
      電気ビル
    • Year and Date
      2014-06-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 希少疾患である肺高血圧症のエコー評価についての教育活動報告2014

    • Author(s)
      河原吾郎、阿部弘太郎、松浦陽子、多田千恵、香月亜希、平川登紀子、堀川史織、佐藤翼、大竹沙矢加、砂川賢二
    • Organizer
      第39回日本超音波検査学会学術集会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2014-06-15
    • Related Report
      2014 Research-status Report
  • [Presentation] Occlusive Vascular Remodeling Is A Consequence Of Hemodynamic Stress In Rats With Severe Pulmonary Arterial Hypertension2014

    • Author(s)
      Abe K, Shinoda M, Kuwabara Y, McMurtry IF, Hirooka Y, Sunagawa K, Oka M
    • Organizer
      American Thoracic Society International Conference 2014
    • Place of Presentation
      San Diego
    • Year and Date
      2014-05-21
    • Related Report
      2014 Research-status Report
  • [Presentation] 肺高血圧症における右室交感神経活動障害は、右心機能障害に比例する2014

    • Author(s)
      阿部弘太郎、廣岡良隆、砂川賢二
    • Organizer
      第54回日本呼吸器学会学術講演会
    • Place of Presentation
      リーガロイヤルホテル大阪
    • Year and Date
      2014-04-26
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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