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Preclinical study and development of novel diagnostic method using molecular imaging with anti-folic acid receptor-beta antibody

Research Project

Project/Area Number 26461148
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionKagoshima University

Principal Investigator

Miyata Masaaki  鹿児島大学, 医歯学域医学系, 准教授 (00347113)

Co-Investigator(Kenkyū-buntansha) 大石 充  鹿児島大学, 医歯学域医学系, 教授 (50335345)
桶谷 直也  鹿児島大学, 医歯学域医学系, 講師 (70598010)
小澤 政之  鹿児島大学, 医歯学域医学系, 教授 (90136854)
Research Collaborator Xu Baohui  Stanford University School of Medicine Division of Vascular Surgery, Department of Surgery, Senior Research Scientist
Dalman Ronald L.  Stanford University School of Medicine Division of Vascular Surgery, Department of Surgery, Professor
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords動脈硬化 / 葉酸レセプターβ / 活性化マクロファージ
Outline of Final Research Achievements

We performed the following 3 projects using a monoclonal antibody against folic acid receptor beta (FR-beta) which is expressed in activated macrophages. 1. We found that fluorescent molecular imaging using anti-FR-beta monoclonal antibody could detect the decrease of atherosclerosis mediated by angiotensin II receptor blocker in apolipoprotein E deficient mice. 2. We confirmed that the apolipoprotein (a) overexpressing transgenic CLAWN miniature swine developed fatty streak in aorta on normal diet. We try to perform the molecular imaging using anti-FR-beta monoclonal antibody with microbubbles detected by ultrasound machine on high fat diet. 3. We established a sandwich ELISA assay using anti-FR-beta monoclonal antibody and measured the soluble FR-beta concentration of human serum. The patients with abdominal aortic aneurysms (AAA) showed a higher serum FR-beta level compared with the normal control. In addition, we confirmed the expression of FR-beta in AAA by immunohistochemistry.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (23 results)

All 2017 2016 2015 2014 Other

All Journal Article (6 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 5 results,  Open Access: 5 results,  Acknowledgement Compliant: 4 results) Presentation (10 results) (of which Int'l Joint Research: 4 results,  Invited: 5 results) Remarks (7 results)

  • [Journal Article] Inhibition or deletion of angiotensin II type 1 receptor suppresses elastase-induced experimental abdominal aortic aneurysms2017

    • Author(s)
      Xuan H, Xu B, Wang W, Tanaka H, Fujimura N, Miyata M, Michie SA, Dalman RL
    • Journal Title

      J Vasc Surg

      Volume: 印刷中 Issue: 2 Pages: 573-584

    • DOI

      10.1016/j.jvs.2016.12.110

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Validity of a Novel Method for Estimation of Low-Density Lipoprotein Cholesterol Levels in Diabetic Patients2016

    • Author(s)
      Chaen H, Kinchiku S, Miyata M, Kajiya S, Uenomachi H, Yuasa T, Takasaki K, Ohishi M
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 23 Issue: 12 Pages: 1355-1364

    • DOI

      10.5551/jat.35972

    • NAID

      130005171049

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Angiotensin-Converting Enzyme Inhibitor Prevents the Worsening of Renal Function in the Late Phase after Percutaneous Coronary Intervention2016

    • Author(s)
      Kanda D, Takumi T, Miyata M, Tokushige A, Sonoda T, Yoshino S, Saihara K, Ohishi M
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 23 Issue: 2 Pages: 233-240

    • DOI

      10.5551/jat.33266

    • NAID

      130005122033

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Associations between blood pressure responses to acute stress and impaired renal function and serum uric acid level2015

    • Author(s)
      Ohno S, Miyata M, Kohjitani A, Tohya A, Ohishi M, Sugiyama K
    • Journal Title

      Clin Exp Hypertens

      Volume: 37 Issue: 8 Pages: 656-660

    • DOI

      10.3109/10641963.2015.1047939

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Effects of Waon Therapy on Chronic Fatigue Syndrome: A Pilot Study2015

    • Author(s)
      Soejima Y, Munemoto T, Masuda A, Uwatoko Y, Miyata M, Tei C
    • Journal Title

      Internal Medicine

      Volume: 54 Issue: 3 Pages: 333-338

    • DOI

      10.2169/internalmedicine.54.3042

    • NAID

      130004903040

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Ang(1-7)/Mas系とAngⅣ/IRAP系2015

    • Author(s)
      宮田昌明, 大石 充
    • Journal Title

      Angiotensin Research

      Volume: 12 Pages: 82-87

    • Related Report
      2014 Research-status Report
  • [Presentation] he validity of a novel method for estimating low-density lipoprotein cholesterol levels in diabetic patients2016

    • Author(s)
      Chaen H, Kinchiku S, Miyata M, Kajiya S, Uenomachi H, Yuasa T, Takasaki K, Ohishi M
    • Organizer
      European Society of Cardiology (ESC) Congress 2016
    • Place of Presentation
      Roma, Italy
    • Year and Date
      2016-08-27
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Alternative autophagy plays a role in the effect of ras-inhibition on arterial senescence and arteriosclerosis2016

    • Author(s)
      Ikeda Y, Iwabayashi M, Sasaki Y, Akasaki Y, Higuchi K, Miyata M, Ohishi M
    • Organizer
      America Heart Association Basic Cardiovascular Science 2016
    • Place of Presentation
      Phoenix, USA
    • Year and Date
      2016-07-17
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 温熱刺激の臨床への応用:和温療法の効果とその利用機序2016

    • Author(s)
      宮田昌明
    • Organizer
      日本東洋医学系物理療法学会 第41回 学術大会・総会
    • Place of Presentation
      筑波大学東京キャンパス(東京都文京区)
    • Year and Date
      2016-03-12
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 心臓リハビリテーションとしての和温療法2016

    • Author(s)
      宮田昌明
    • Organizer
      第64回 日本心臓病学会学術集会
    • Place of Presentation
      東京国際フォーラム(東京都・千代田区)
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Inhibition of renin-angiotensin signal retards arterial senescence and development of atherosclerosis in apolipoprotein eknockout mice via induction of alternative autophagy2015

    • Author(s)
      Iwabayashi M, Ikeda Y, Sasaki Y, Akasaki Y, Miyata M, Sadoshima J , Ohishi M
    • Organizer
      AHA Scientific Sessions 2015
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2015-11-07
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] ディベート1. 降圧薬は併用か?増量か?2015

    • Author(s)
      宮田昌明
    • Organizer
      第38回 日本高血圧学会総会
    • Place of Presentation
      ひめぎんホール(愛媛県松山市)
    • Year and Date
      2015-10-09
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 熱帯環境 温熱刺激に対する生体反応と治療への応用:和温療法2015

    • Author(s)
      宮田昌明
    • Organizer
      第19回日本適応医学会学術集会
    • Place of Presentation
      一橋講堂(東京都千代田区)
    • Year and Date
      2015-09-12
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Selective estrogen receptor modulator retards arterial senescence and atherosclerosis via upregulation of sirt-1 and autophagy in post-menopause model mouse2015

    • Author(s)
      Ikeda Y, Miyauchi T, Iwabayashi M, Sasaki Y, Akasaki Y, Miyata M, Ohishi M
    • Organizer
      AHA Basic Cardiovascular Science (BCVS) 2015
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2015-07-13
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 遺伝子改変ブタを用いた成人病メカニズムへの戦略:Lp(a)と動脈硬化2015

    • Author(s)
      宮田昌明、小澤政之
    • Organizer
      先進医用ミニブタの開発と前臨床研究拠点形成プロジェクト第3回公開シンポジウム
    • Place of Presentation
      鹿児島市(鹿児島大学農・獣共通棟)
    • Year and Date
      2015-03-24
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 温熱刺激による血管老化と動脈硬化の抑制効果2014

    • Author(s)
      宮田昌明
    • Organizer
      第79回 日本温泉気候物理医学会総会
    • Place of Presentation
      京都(京都国際会議場)
    • Year and Date
      2014-05-11 – 2014-05-14
    • Related Report
      2014 Research-status Report
  • [Remarks] 鹿児島大学産学官連携推進センター 活性化マクロファージを標的とした動脈硬化の新規診断・治療法の開発

    • URL

      http://www.rdc.kagoshima-u.ac.jp/rdc/search/upload/miyata-med.pdf

    • Related Report
      2016 Annual Research Report
  • [Remarks] 鹿児島大学研究者総覧、宮田昌明

    • URL

      http://kuris.cc.kagoshima-u.ac.jp/407594.html

    • Related Report
      2016 Annual Research Report 2014 Research-status Report
  • [Remarks] 鹿児島大学大学院 医歯学総合研究科 心臓血管・高血圧内科学ホームページ

    • Related Report
      2016 Annual Research Report
  • [Remarks] 鹿児島大学産学官連携推進センター 活性化マクロファージを標的とした動脈硬化の新規診断・治療法の開発

    • URL

      http://www.rdc.kagoshima-u.ac.jp/rdc/search/upload/miyata-med.pdf

    • Related Report
      2015 Research-status Report 2014 Research-status Report
  • [Remarks] 鹿児島大学研究者総覧、宮田昌明

    • URL

      http://ris.kuas.kagoshima-u.ac.jp/html/100004926_ja.html?k=%E5%AE%AE%E7%94%B0%E6%98%8C%E6%98%8E

    • Related Report
      2015 Research-status Report
  • [Remarks] 鹿児島大学大学院 医歯学総合研究科 心臓血管・高血圧内科学 スタッフ紹介

    • URL

      http://www.kufm.kagoshima-u.ac.jp/~intmed1/staff/details/miyata.html

    • Related Report
      2015 Research-status Report
  • [Remarks] 鹿児島大学大学院 医歯学総合研究科 心臓血管・高血圧内科学ホームページ

    • URL

      http://www.kufm.kagoshima-u.ac.jp/~intmed1/

    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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