| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Hydrogen peroxide-inducible clone-5 (Hic-5) is a focal adhesion adaptor protein, which is involved in vascular disorders such as atherosclerosis and aneurysms. To evaluate the therapeutic potential of Hic-5 in vascular disorders, Hic-5 siRNA was intravenously injected through the tail vein of the HCD-fed or AngII treated apoE deficient mice. Hic-5 knockdown significantly suppressed the formation of atherosclerotic and aneurysmal lesions. Moreover, we report the structure-based design of new potent peptides with Hic-5 inhibitory efficiency. The peptides are developed by rational design, based on structural and physicochemical properties. In vitro analysis shows that some of the peptides possess a significant inhibitory effect against Hic-5.
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