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Cross-talk between uppper and lower airway involvenet assesed by CT imaging and biomarkers in asthmatic subjects

Research Project

Project/Area Number 26461151
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionHokkaido University

Principal Investigator

Konno Satoshi  北海道大学, 医学研究科, 准教授 (20399835)

Co-Investigator(Kenkyū-buntansha) 清水 薫子  北海道大学, 大学病院, 特任助教 (40399853)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords気管支喘息 / バイオマーカー / 副鼻腔病変
Outline of Final Research Achievements

This study was aimed aim to evaluate the effect of smoking on the relationship
between sinus involvement and asthma-related indices. Resuts from this study showed that sinusitis and asthma are expressions of a common process characterized by intense Th2-related inflammation,regardless of smoking status. However, such Th2-related inflammation may be linked withfixed airflow limitation only in non-smoking asthmatics.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (8 results)

All 2017 2016 2015 2014

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (5 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Sinus Computed Tomographic Findings in Adult Smokers and Nonsmokers with Asthma. Analysis of Clinical Indices and Biomarkers.2017

    • Author(s)
      Kimura H, et al
    • Journal Title

      Ann Am Thorac Soc

      Volume: 14 Issue: 3 Pages: 332-341

    • DOI

      10.1513/annalsats.201606-463oc

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Contrasting associations of body mass index and measles with asthma and rhinitis in young adults2015

    • Author(s)
      Kimura H, Konno S, Isada A, Maeda Y, Musashi M, Nishimura M
    • Journal Title

      Allergy Asthma Proc

      Volume: 36 Issue: 4 Pages: 293-299

    • DOI

      10.2500/aap.2015.36.3837

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Distinct Phenotypes of Cigarette Smokers Identified by Cluster Analysis of Patients with Severe Asthma2015

    • Author(s)
      Konno S, Taniguchi N, Makita H, Nakamaru Y, Shimizu K, Shijubo N, Fuke S, Takeyabu K, Oguri M, Kimura H, Maeda Y, Suzuki M, Nagai K, Ito YM, Wenzel SE, Nishimura M
    • Journal Title

      Ann Am Thorac Soc

      Volume: 12 Issue: 12 Pages: 1771-1780

    • DOI

      10.1513/annalsats.201507-407oc

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Sinus Computed Tomographic Findings in Adult Smokers and Nonsmokers with Asthma. Analysis of Clinical Indices and Biomarkers2016

    • Author(s)
      Kimura H, Konno S, et al.
    • Organizer
      Am Thorac Soc International Conference
    • Place of Presentation
      米国 サンフランシスコ
    • Year and Date
      2016-05-15
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 喘息患者における副鼻腔CT所見とその関連因子2015

    • Author(s)
      木村孔一,今野哲,中丸裕爾,牧田比呂仁,谷口菜津子,清水薫子,鈴木雅,西村正治
    • Organizer
      第64回日本アレルギー学会学術大会
    • Place of Presentation
      新高輪プリンスホテル(東京都,港区)
    • Year and Date
      2015-05-26
    • Related Report
      2015 Research-status Report
  • [Presentation] Sinus Computed Tomographic Findings in Asthmatics: Comparison between Mild-to-moderate and Severe Asthma and Associations with Asthma-related Indices2015

    • Author(s)
      Kimura H, Konno S, Nakamaru Y, Makita H, Taniguchi N, Shimizu K, Suzuki M, Nishimura M
    • Organizer
      The 110th American Thoracic Society International Conference
    • Place of Presentation
      Colorado convention center (Denver, USA)
    • Year and Date
      2015-05-20
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Associations of serum periostin level with sinusitis severity and persistent airflow limitation in severe asthma2014

    • Author(s)
      Kimura H, Konno S, Nakamaru Y, Makita H, Taniguchi N, Shimizu K, Maeda Y, Suzuki M, Nagai K, Ono J, Izuhara K, Nishimura M.
    • Organizer
      The 109th American Thoracic SccietyInternational Conference
    • Place of Presentation
      San Diego Convention Center (San Diedo, USA)
    • Year and Date
      2014-05-21
    • Related Report
      2014 Research-status Report
  • [Presentation] 難治性喘息患者における血清ペリオスチン濃度と呼吸機能・副鼻腔陰影重症度との関連2014

    • Author(s)
      木村孔一、今野 哲、中丸裕爾、牧田比呂仁、谷口菜津子、清水薫子、前田由起子、鈴木雅、長井桂、小野純也、太田昭一郎、出原賢治、西村正治
    • Organizer
      第26回日本アレルギー学会春季臨床大会
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2014-05-09
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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