Establishment of a Web-Based Inquiry System for Elemental Analysis of Lung Tissue

• Project/Area Number: 26461156
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: 独立行政法人国立病院機構西新潟中央病院(臨床研究部) (2016); Niigata University (2014-2015)
• Principal Investigator: Moriyama Hiroshi 独立行政法人国立病院機構西新潟中央病院(臨床研究部), 統括診療部, 呼吸器内科医師 (60463981)
• Co-Investigator(Kenkyū-buntansha): 高田 俊範 新潟大学, 医歯学総合病院, 特任教授 (40361919)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 元素分析 / オンライン / 職業性肺疾患 / パラフィンブロック / 一般病院 / 電子線マイクロアナライザー / 超硬合金肺 / 一般医療機関 / 24時間受付 / 免疫組織化学

Outline of Final Research Achievements

Workers develop occupational lung diseases by inhalation to various substances. Elemental analysis serves well to detect the inhaled substances in the lung specimen, but it is currently performed in limited facilities. We introduced a web-based inquiry system for elemental analysis of lung tissue in 2014.　We had 45 online inquiries about elemental analysis of lung tissue from 2014 to 2016. We accepted 41 out of 45 inquiries and subjected their lung specimens to elemental analysis. Eight cases were finally diagnosed as hard metal lung disease, and three cases, aluminum lung.A web-based inquiry system for elemental analysis of lung tissue was useful to accept inquiries about the analyses. It was convenient for users with easy access to this technique and smooth processing of lung specimens to make the accurate diagnosis of occupational lung diseases.

Research Products

• [Journal Article] A case of mixed dust pneumoconiosis with desquamative interstitial pneumonia-like reaction in an aluminium welder (2017)
  • Author(s): Yuki Iijima, Masahiro Bando, Hideaki Yamasawa, Hiroshi Moriyama, Tamiko Takemura, Toshihiro Niki, Yukihiko Sugiyama
  • Journal Title: Respiratory Medicine Case Reports Volume: 20 Pages: 150-153
  • DOI: 10.1016/j.rmcr.2017.02.002
  • Peer Reviewed / Open Access
• [Journal Article] Elemental analysis of occupational granulomatous lung disease by electron probe microanalyzer with wavelength dispersive spectrometer: Two case reports (2016)
  • Author(s): Hiromi Tomioka, Toshihiko Kaneda, Eiji Katsuyama, Masanori Kitaichi, Hiroshi Moriyama, Eiichi Suzuki
  • Journal Title: Respiratory Medicine Case Reports Volume: 18 Pages: 66-72
  • DOI: 10.1016/j.rmcr.2016.04.009
  • Peer Reviewed / Open Access
• [Journal Article] Two cases of hard metal lung disease showing gradual improvement in pulmonary function after avoiding dust exposure (2015)
  • Author(s): Hiroya Terui, Satoshi Konno, Kichizo Kaga, Yoshihiro Matsuno, Kanako C. Hatanaka, Hiromi Kanno, Hiroshi Moriyama, Motohiro Uo, Masaharu Nisihimura
  • Journal Title: Journal of Occupational Medicine and Toxicology Volume: 10: 29 Issue: 1 Pages: 1-7
  • DOI: 10.1186/s12995-015-0070-9
  • NAID: 120005651854
  • Peer Reviewed / Open Access
• [Journal Article] An observational study of giant cell interstitial pneumonia and lung fibrosis in hard metal lung disease. (2014)
  • Author(s): Tanaka J, Moriyama H, Terada M, et al.
  • Journal Title: British Medical Journal Open Volume: 4 Pages: 1-11
  • Peer Reviewed / Open Access
• [Presentation] Establishment of a Web-Based Inquiry System for Elemental Analysis of Lung Tissue of Occupational Lung Diseases (2017)
  • Author(s): H. Moriyama, M. Kobayashi, A.Aoki, K. Asakawa, T. Sakagami, T.Koya,
  • Organizer: American Thoracic Society 2017 International Conference
  • Place of Presentation: Washington D.C., America
  • Year and Date: 2017-05-22
  • Int'l Joint Research
• [Presentation] Elemental Analysis of Autoimmune Pulmonary Alveolar Proteinosis (2015)
  • Author(s): H. Moriyama, M. Kobayashi, A. Aoki, K. Asakawa, T. Sakagami, T. Koya, H. Kagamu, T. Takada, I. Narita, Y. Inoue, K. Nakata
  • Organizer: American Thoracic Sosiety International Conference 2015 Denver
  • Place of Presentation: デンバー（米国）
  • Year and Date: 2015-05-19
  • Int'l Joint Research
• [Presentation] 肺組織の元素分析 (2014)
  • Author(s): 森山寛史
  • Organizer: 日本産業衛生学会 産業医・産業看護全国協議会
  • Place of Presentation: 石川県金沢市金沢文化会館
  • Year and Date: 2014-09-27
  • Invited