Neutrophil Extracelluar Traps in Severe influenza-elated pneumonia
| Project/Area Number |
26461158
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Tohoku Medical and Pharmaceutical University (2015-2016)
Osaka University (2014) |
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Principal Investigator |
SEKI Masafumi 東北医科薬科大学, 医学部, 教授 (80432970)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | インフルエンザ / 肺炎 / サイトカインストーム / 好中球 / 敗血症 / ネッツ / ワクチン / 耐性菌 / NETs / マクロライド系薬 / MRSA / 真菌症 / 誤嚥性肺炎 / ヒトメタニューモウイルス / 真菌 |
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| Outline of Final Research Achievements |
The aim of this study is that examination whether excessive immunological reaction, including NETs (Neutrophil Extracellular Traps) make the damage to host and patients although these regularly could control the infectious pathogens.
We reported these possible cases including severe influenza-related pneumonia, and analyzed mice models of sepsis and influenza infection. In addition, we investigated the diagnosis method including biomarkers (eg. procalcitonin) in clinical fields.
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] Toll-like Receptor 4 Agonistic Antibody Promotes Host Defense against Chronic Pseudomonas aeruginosa Lung Infection in Mice.2016
Author(s)
4)Nakamura S, Iwanaga N, Seki M, Fukudome K, Oshima K, Miyazaki T, Izumikawa K, Yanagihara K, Miyazaki Y, Mukae H, Kohno S.
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Journal Title
Infect Immun.
Volume: 84
Issue: 7
Pages: 1986-1993
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Usefulness of a phage-open reading frame typing (POT) kit for rapid identification of Methicillin-Resistant Staphylococcus aureus (MRSA) transmission in a tertiary hospital2015
Author(s)
Takahashi H, Seki M, Yamamoto N, Hamaguchi S, Ojima M, Hirose T, Yoshiya K, Toyokawa M, Nishi I, Ogura H, Shimazu T, Tomono K.
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Journal Title
Infection and Drug Resistance
Volume: 8
Pages: 107-111
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Invasive pulmonary aspergillosis due to Aspergillus lentulus: Successful treatment of a liver transplant patient.2015
Author(s)
Yoshida H, Seki M, Umeyama T, Urai M, Kinjo Y, Nishi I, Toyokawa M, Kaneko Y, Ohno H, Miyazaki Y, Tomono K.
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Journal Title
J Infect Chemother
Volume: epub
Issue: 6
Pages: 479-481
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article]2014
Author(s)
Seki M., Ohno H., Gotoh K., Motooka D., Nakamura S., Iida T., Miyazaki Y., Tomono K.
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Journal Title
IDCases
Volume: 1
Issue: 1
Pages: 5-8
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Severe respiratory failure due to co-infection with human metapneumovirus and Streptococcus pneumoniae.2014
Author(s)
Seki M, Yoshida H, Gotoh K, Hamada N,Motooka D, Nakamura S, Yamamoto N, Hamaguchi S, Akeda Y, Watanabe H, Iida T, and Tomono K.
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Journal Title
Respiratory Medicine Case Reports
Volume: 12
Pages: 13-15
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Efficacy of combination therapy with oseltamivir phosphate and azithromycin for influenza.2014
Author(s)
Kakeya H, Seki M, Izumikawa K, Kosai K, Morinaga Y, Kurihara S, Nakamura S, Imamura Y, Miyazaki T, tsukamoto M, Yanagihara K, Tashiro T, Kohno S.
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Journal Title
PLoS One
Volume: 9
Issue: 3
Pages: e91293-e91293
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Book] 内科2015
Author(s)
関 雅文
Total Pages
5
Publisher
南江堂
Related Report
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