Pathogenesis and tumorigenesis of respiratory neoplasm occurring in infection and inflammation

• Project/Area Number: 26461162
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Kochi University
• Principal Investigator: Kamioka Mikio 高知大学, 教育研究部医療学系臨床医学部門, 助教 (00274374)
• Co-Investigator(Kenkyū-buntansha): 大畑 雅典 高知大学, 教育研究部医療学系基礎医学部門, 教授 (50263976) ; 村上 雅尚 高知学園短期大学, その他部局等, 准教授(移行) (80571017)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 呼吸器悪性腫瘍 / ウイルス / 感染症 / 呼吸器腫瘍 / 微生物

Outline of Final Research Achievements

Lung cancer is a leading cause of cancer-related mortality. Although smoking is the major risk factor for the development of lung cancer, the number of lung cancer occurring in never smokers has increased in recent times. In this study, we focused on Merkel cell polyoma virus (MCPyV) detected in Merkel cell tumor, a neurogenic tumor of the skin. We examined that Merkel cell polyoma virus is factor of lung cancer in never smokers. Transfection analyses to lung cancer cell lines derived from Caucasian or Asian virus vectors were performed and detected to be different in infectious form.
It is necessary to profile the expression in the MCPyV-transformed lung cancer cell lines and clarify the relationship with the pathologenesis and tumorigenesis.

Research Products

• [Journal Article] Intravascular hemolysis in patients with mitral regurgitation: Evaluation by erythrocyte creatine. (2018)
  • Author(s): Sugiura T, Okumiya T, Kamioka M, Kubo T, Hirakawa Y, Hisahara T, Matsumura Y.
  • Journal Title: J Cardiol. Volume: 71 Issue: 4 Pages: 414-418
  • DOI: 10.1016/j.jjcc.2017.10.006
  • Peer Reviewed / Open Access
• [Journal Article] Relationship between matrix metalloproteinase-3 serum level and pulmonary artery systolic pressure in patients with rheumatoid arthritis. (2018)
  • Author(s): Sugiura T, Kamioka M, Yamanaka S, Hisahara T, Hirakawa Y, Matsumura Y.
  • Journal Title: Heart Vessels. Volume: 33 Issue: 2 Pages: 191-197
  • DOI: 10.1007/s00380-017-1045-9
  • Peer Reviewed / Open Access
• [Journal Article] Ecology of Merkel Cell Polyomavirus in Healthy Skin Among Individuals in an Asian Cohort (2016)
  • Author(s): Hashida Y, Kamioka M, Tanaka M, Hosokawa S, Murakami M, Nakajima K, Kikuchi H, Fujieda M, Sano S, Daibata M
  • Journal Title: J Infect Dis Volume: 213(11) Issue: 11 Pages: 1708-1716
  • DOI: 10.1093/infdis/jiw040
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Autoimmunity and pulmonary hypertension in patients with Graves’disease (2014)
  • Author(s): Sugiura T, Yamanaka S, Takeuchi H, Morimoto N, Kamioka M, Matsumura Y.
  • Journal Title: Heart and vessels Volume: e pub Issue: 5 Pages: 1-5
  • DOI: 10.1007/s00380-014-0518-3
  • Peer Reviewed / Open Access
• [Presentation] 頸動脈病変による幼若血小板分画への影響 (2017)
  • Author(s): 上岡樹生、宮尾恵示、竹内啓晃、久原太助、岡崎瑞穂、杉浦哲朗、山中茂雄、松村敬久
  • Organizer: 第64回日本臨床検査医学会学術集会
• [Presentation] 膠芽腫におけるウィルス感染 (2016)
  • Author(s): 上岡樹生, 橋田裕美子,大畑雅典,竹内啓晃,杉浦哲朗,松村敬久
  • Organizer: 第63回日本臨床検査医学会学術集会
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市）
  • Year and Date: 2016-09-01
• [Presentation] 同一患者におけるHelicobacter pyloriの生化学的および遺伝子多様性の検討 (2016)
  • Author(s): 吉良瑞喜,岡崎亜美,森本徳仁,上岡樹生,松村敬久,杉浦哲朗,竹内啓晃
  • Organizer: 第63回日本臨床検査医学会学術集会
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市）
  • Year and Date: 2016-09-01
• [Presentation] Virus infection in glioblastoma multiforme (GBM): Possible association of human papillomavirus with pathogenesis of GBM (2015)
  • Author(s): 橋田裕美子、村上雅尚、細川世奈、田中望紅、八幡俊男、谷口亜裕子、上岡樹生、弘井誠、上羽哲也、大畑雅典
  • Organizer: 第63回日本ウイルス学会学術集会
  • Place of Presentation: 福岡国際会議場（福岡市）
  • Year and Date: 2015-11-22
• [Presentation] 非小細胞肺癌発症におけるメルケル細胞ポリオーマウイルスの関与 (2015)
  • Author(s): 上岡樹生・橋田裕美子・松村敬久・大畑雅典・杉浦哲朗
  • Organizer: 第62回臨床検査医学会学術集会
  • Place of Presentation: 長良川国際会議場・岐阜都ホテル（岐阜市）
  • Year and Date: 2015-11-19
• [Presentation] Nm23-H1 regulates cell migration via interaction with Asef1 and Asef2 (2015)
  • Author(s): Masanao Murakami, Yumiko Hashida, Mikio Kamioka, Yoshihiro Kawasaki, Kazuyosi Yanagihara, Shigetoshi Matsuzasi, Tetsu Akiyama, and Masanori Daibata
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場（名古屋市）
  • Year and Date: 2015-10-08
• [Presentation] 膠芽腫におけるウイルス感染の調査 (2014)
  • Author(s): 橋田裕美子、八幡俊男、村上雅尚、谷口亜裕子、上岡樹生、上羽哲也、大畑雅典
  • Organizer: 日本ウイルス学会学術集会
  • Place of Presentation: パシフィコ横浜（神奈川県・横浜市）
  • Year and Date: 2014-11-10 – 2014-11-12
• [Presentation] PCR array analysis of gene expression profiles in chronic active Epstein-Barr virus infection. (2014)
  • Author(s): Masanao Murakami, Yumiko Hashida, Masayuki Imajoh, Akihiko Maeda, Mikio Kamioka, Yasutaka Senda, Tetsuya Sato, Mikiya Fujieda, Hiroshi Wakiguchi, Masanori Daibata.
  • Organizer: International Herpesvirus Workshop
  • Place of Presentation: Kobe Convention Center (Kobe, Japan)
  • Year and Date: 2014-07-19 – 2014-07-23
• [Remarks] 高知大学医学部病態情報診断学講座
  • URL: http://www.kochi-ms.ac.jp/~fm_clncl/access.html
• [Remarks] 高知大学微生物学講座
  • URL: http://www.kochi-ms.ac.jp/~ff_mcrbi/gyouseki.html
• [Remarks]
  • URL: http://www.kochi-ms.ac.jp/~ff_mcrbi/gyouseki.html
• [Remarks]
  • URL: http://www.kochi-ms.ac.jp/
• [Remarks] 高知大学医学部 微生物学教室
  • URL: http://www.kochi-ms.ac.jp/~ff_mcrbi/kenkyu.html