| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Allergic bronchopulmonary mycosis (ABPM) is a refractory allergic airway disease characterized by a hypersensitivity reaction to fungi colonizing the airways. Previously, we reported the induction of mucin-related MUC5AC gene in the airway epithelial cells by serine protease derived from Aspergillus fumigatus extract. In this study, we conducted DNA microarray analysis of a human bronchial epithelial cell line, stimulated with serine protease derived from A. fumigatus, to identify novel therapeutic targets for ABPM. We confirmed 428 genes upregulated by serine protease, including cytokine-cytokine receptor-related genes, such as TSLP, IL-1α, and VEGF. Some of the cytokine-cytokine receptor-related genes were induced through epidermal growth factor receptor.
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