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Identification of the genomic landscape in pulmonary neuroendocrine tumor

Research Project

Project/Area Number 26461168
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionNippon Medical School

Principal Investigator

MIYANAGA AKIHIKO  日本医科大学, 医学部, 助教 (00591281)

Co-Investigator(Kenkyū-buntansha) 弦間 昭彦  日本医科大学, 医学部, 教授 (20234651)
清家 正博  日本医科大学, 医学部, 教授 (30366687)
Co-Investigator(Renkei-kenkyūsha) YAMADA Tesshi  国立がん研究センター (30221659)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords次世代シーケンサー / 肺神経内分泌腫瘍 / 遺伝子変異 / 融合遺伝子 / 肺カルチノイド
Outline of Final Research Achievements

The aim of this study is to identify gene alterations can be linked to therapeutic target in pulmonary neuroendocrine tumor using next-generation sequencers. We performed the comprehensive whole exon and RNA sequencing of 25 fresh frozen tissue samples (21 typical carcinoid and 4 atypical carcinoid) using Illumina HiSeq 2000. We found 8 novel fusion transcripts including one derived from chromosomal translocation between the TRIB2 and PRKCE genes. In addition, we identified a total of 139 gene alterations. Interestingly, we also detected mutations in mucin genes (MUC2, MUC4 and MUC6). All the 8 fusion genes and MUC4 gene mutation were obtained from post-operative recurrence of PCs tumor.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (2 results)

All 2016 2015

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Book (1 results)

  • [Journal Article] Hippo Pathway Gene Mutations in Malignant Mesothelioma, Revealed by RNA and Targeted Exon Sequencing2015

    • Author(s)
      Miyanaga A, Masuda M, Tsuta K, Kawasaki K, Nakamura Y, Sakuma T, Asamura H, Gemma A, Yamada T.
    • Journal Title

      J Thorac Oncol

      Volume: 10(5) Issue: 5 Pages: 844-851

    • DOI

      10.1097/jto.0000000000000493

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Book] Molecular Targeted Therapy of Lung Cancer, Chapter12 Minor-Driver mutant2016

    • Author(s)
      Akihiko Miyanaga
    • Total Pages
      13
    • Publisher
      Springer Nature
    • Related Report
      2016 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2019-03-29  

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