| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Alveolar stem cells were tracked by lineage tacing system. Among stem cell markers, Bmi1 expressed in the some portion of alveolar type 2(AT2) cells (SPC(+) cells). After Radiation injury, both AT2 and AT1 cells were regenerated from Bmi1(+) cells.
Mutant form of Kras (Kras G12D) caused the clonal lung cancer development from one Bmi1(+) cells. On the other hand, all mice died after mutnat Kras was expressed in the SPC(+) alveolar type 2 cells within 8weeks. In this time point, the clonal expansion of SPC(+) cells were observed but no obvious lung cancer developed. This indicate that mice were dead due to the suffocation probably by the oversecretion of surfactant proteins. These results indicate lung cancer might be originated from the Bmi1(+) cells which are some part of AT2 cells.
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