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Effect of iron deficiency on animal model of pulmonary emphysema

Research Project

Project/Area Number 26461177
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionYamagata University

Principal Investigator

SHIBATA Yoko  山形大学, 医学部, 講師 (60333978)

Co-Investigator(Renkei-kenkyūsha) KUROTANI Reiko  山形大学, 大学院理工学研究科, 准教授 (00453043)
ABE Shuichi  山形大学, 医学部, 非常勤講師 (40400543)
INOUE Sumito  山形大学, 医学部, 助教 (70466621)
Research Collaborator SATO Masamichi  
SATO Kento  
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords慢性閉塞性肺疾患 / 肺気腫 / 鉄 / たばこ / 鉄欠乏 / 喫煙 / COPD / 血清鉄 / COPD
Outline of Final Research Achievements

Serum iron is reportedly related to smoking tolerance. It is also known that low serum iron levels are associated with rapid decline in respiratory function due to smoking. In this study, we investigated the mechanism why low level of serum iron leads to a decline in respiratory function in the smoke-exposed mouse emphysema model. After administering an iron deficient diet to mice, smoking exposure was carried out on the mice for two weeks using a smoking exposure apparatus. In bronchoalveolar lavage analysis, significant accumulation of alveolar macrophages was observed in the iron deficient food intake group as compared with the normal food ingestion group. Next, after the mice in both groups were exposed to smoking for 8 weeks, respiratory function tests and pathological examinations were performed to evaluate emphysema formation. Emphysema formation progressed in the iron deficient diet group compared to the normal diet group.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (18 results)

All 2017 2016 2015 2014

All Journal Article (11 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 10 results,  Open Access: 6 results,  Acknowledgement Compliant: 2 results) Presentation (7 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] 血清鉄低値は呼吸機能低下の原因なのか2017

    • Author(s)
      柴田陽光、佐藤建人、井上純人
    • Journal Title

      別冊BIO Clinica 呼吸器疾患と慢性炎症

      Volume: 6 Pages: 101-105

    • Related Report
      2016 Annual Research Report
  • [Journal Article] MafB enhances the phagocytic activity of RAW264.7 macrophages by promoting Fcgr3 expression.2017

    • Author(s)
      Nemoto T, Shibata Y, Inoue S, Igarashi A, Tokairin Y, Yamauchi K, Kimura T, Sato M, Sato K, Nakano H, Abe S, Nishiwaki M, Kubota I.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 482 Issue: 2 Pages: 375-381

    • DOI

      10.1016/j.bbrc.2016.11.070

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of chemokine C-C motif ligand-1 in acute and chronic pulmonary inflammations.2016

    • Author(s)
      Kishi H, Sato M, Shibata Y, Sato K, Inoue S, Abe S, Kimura T, Nishiwaki M, Yamauchi K, Nemoto T, Igarashi A, Tokairin Y, Nakajima O, Kubota I.
    • Journal Title

      Springerplus

      Volume: 5 Issue: 1 Pages: 1241-1241

    • DOI

      10.1186/s40064-016-2904-z

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum uric acid levels and mortality in the Japanese population: the Yamagata (Takahata) study.2016

    • Author(s)
      Kamei K, Konta T, Ichikawa K, Sato H, Suzuki N, Kabasawa A, Suzuki K, Hirayama A, Shibata Y, Watanabe T, Kato T, Ueno Y, Kayama T, Kubota I.
    • Journal Title

      Clin Exp Nephrol.

      Volume: 印刷中

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Reference values of MostGraph measures for middle-aged and elderly Japanese individuals who participated in annual health checkups.2016

    • Author(s)
      Abe Y, Shibata Y, Igarashi A, Inoue S, Sato K, Sato M, Nemoto T, Kobayashi M, Nishiwaki M, Kimura T, Tokairin Y, Kayama T, Kubota I
    • Journal Title

      Respiratory Investigation

      Volume: 印刷中

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Low arterial blood oxygenation is associated with calcification of the coronary arteries in patients with chronic obstructive pulmonary disease.2015

    • Author(s)
      Inoue S, Shibata Y, Kishi H, Hasegawa H, Nitobe J, Iwayama T, Yashiro Y, Nemoto T, Sato K, Nakano H, Sato M, Nunomiya K, Aida Y, Yamauchi K, Igarashi A, Abe S, Kubota I.
    • Journal Title

      Respir Investig

      Volume: 53 Issue: 3 Pages: 111-116

    • DOI

      10.1016/j.resinv.2015.01.002

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] SCGB3A2 Inhibits Acrolein-Induced Apoptosis through Decreased p53 Phosphorylation2015

    • Author(s)
      Kurotani R, Shima R, Miyano Y, Sakahara S, Matsumoto Y, Shibata Y, Abe, Kimura S.
    • Journal Title

      ACTA HISTOCHEMICA ET CYTOCHEMICA

      Volume: 48 Issue: 2 Pages: 61-68

    • DOI

      10.1267/ahc.14065

    • NAID

      130005068296

    • ISSN
      0044-5991, 1347-5800
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Slight increase in urinary albumin excretion within the normal range predicts incident hypertension in a community-based Japanese population: the Takahata study2015

    • Author(s)
      Hirayama A, Konta T, Hozawa A, Kawasaki R, Watanabe T, Shibata Y, Kayama T, Fukao A, Kubota I
    • Journal Title

      Hypertension Research

      Volume: 38 Issue: 1 Pages: 56-60

    • DOI

      10.1038/hr.2014.117

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of heart-type fatty acid-binding protein with cardiovascular risk factors and all-cause mortality in the general population: the Takahata study.2014

    • Author(s)
      Otaki Y, Watanabe T, Takahashi H, Hirayama A, Narumi T, Kadowaki S, Honda Y, Arimoto T, Shishido T, Miyamoto T, Konta T, Shibata Y, Fukao A, Daimon M, Ueno Y, Kato T, Kayama T, Kubota I.
    • Journal Title

      PLoS One

      Volume: 9 Issue: 5 Pages: e94834-e94834

    • DOI

      10.1371/journal.pone.0094834

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between plasma adiponectin levels and decline in forced expiratory volume in 1 s in a general Japanese population: the Takahata study.2014

    • Author(s)
      Sato K, Shibata Y, Abe S, Inoue S, Igarashi A, Yamauchi K, Aida Y, Nunomiya K, Nakano H, Sato M, Kimura T, Nemoto T, Watanabe T, Konta T, Ueno Y, Kato T, Kayama T, Kubota I.
    • Journal Title

      Int J Med Sci.

      Volume: 11 Issue: 8 Pages: 758-764

    • DOI

      10.7150/ijms.8919

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibition of elastase-pulmonary emphysema in dominant-negative MafB transgenic mice.2014

    • Author(s)
      Aida Y, Shibata Y, Abe S, Inoue S, Kimura T, Igarashi A, Yamauchi K, Nunomiya K, Kishi H, Nemoto T, Sato M, Sato-Nishiwaki M, Nakano H, Sato K, Kubota I
    • Journal Title

      Int J Biol Sci.

      Volume: 10 Issue: 8 Pages: 882-894

    • DOI

      10.7150/ijbs.8737

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 鉄欠乏状態下での喫煙曝露の影響についての検討2017

    • Author(s)
      佐藤建人等
    • Organizer
      第57回日本呼吸器学会学術講演会
    • Place of Presentation
      東京国際フォーラム(東京千代田区)
    • Year and Date
      2017-04-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] Serum hepcidin and iron are associated with non-small cell lung cancer stage2016

    • Author(s)
      Sato K, Shibata Y, Inoue S, Igarash A, Tokairin Y, Yamauchi K, Kimura T, Nemoto T, Sato M, Nakano H, Abe Y, Kubota I
    • Organizer
      ERS International Congress 2016
    • Place of Presentation
      London (United Kingdom of Great Britain)
    • Year and Date
      2016-09-03
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of Iron Deficiency on Lipopolysaccharide-Induced Acute Lung Injury.2016

    • Author(s)
      Sato K, Abe Y, Kobayashi M, Sato M, Nemoto T, Nishiwaki M, Kimura T, Yamauchi K, Igarashi A, Tokairin Y, Inoue S, Kubota I, Shibata Y
    • Organizer
      American Thoracic Society International Conference 2016
    • Place of Presentation
      San Francisco (America)
    • Year and Date
      2016-05-14
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] マウス組織肺におけるIreb2の局在と発現の検討2016

    • Author(s)
      佐藤正道
    • Organizer
      第56回日本呼吸器学会学術講演会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2016-04-08
    • Related Report
      2015 Research-status Report
  • [Presentation] 高齢者肺炎における血清鉄と予後の関係2016

    • Author(s)
      佐藤建人
    • Organizer
      第56回日本呼吸器学会学術講演会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2016-04-08
    • Related Report
      2015 Research-status Report
  • [Presentation] 低鉄状態がLipopolysaccharide誘発急性肺障害に及ぼす影響についての検討2016

    • Author(s)
      佐藤建人
    • Organizer
      第56回日本呼吸器学会学術講演会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2016-04-08
    • Related Report
      2015 Research-status Report
  • [Presentation] 鉄欠乏状態における肺の鉄代謝の解析2015

    • Author(s)
      佐藤建人
    • Organizer
      第55回日本呼吸器学会学術講演会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2015-04-17 – 2015-04-19
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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