An analysis of new mechanisms of pulmonary emphysema using Elovl6 deficient mice.
Project/Area Number |
26461179
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Respiratory organ internal medicine
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Research Institution | Gunma University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
松井 弘樹 群馬大学, 大学院保健学研究科, 講師 (20431710)
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Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | Elovl6 / 肺気腫 / 飽和脂肪酸 / 不飽和脂肪酸 |
Outline of Final Research Achievements |
We examined the role of Elongation of long chain fatty acid member 6 (Elovl6) which is a rate-limiting enzyme catalysing the elongation of saturated and monounsaturated fatty acids on the development of pulmonary emphysema using Elobl6-deficient mice. In the early stage of emphysema, the expression of Elovl6 was increased in alveolar type II epithelial cells, and increased Elovl6 induced derangement of fatty acid profile and exacerbated pulmonary emphysema. On the other hand, in the chronic phase of emphysema, the expression of Elovl6 returned to the level of normal mice, and the fatty acid profile of lung was similar to normal mice. Our findings demonstrate a previously unappreciated role for Elovl6 in the pathogenesis of pulmonary emphysema.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Early increase in serum fatty acid binding protein 4 levels in patients with acute myocardial infarction2017
Author(s)
Obokata M, Iso T, Ohyama Y, Sunaga H, Kawaguchi T, Matsui H, Iizuka T, Fukuda N, Takamatsu H, Koitabashi N, Funada R, Takama N, Kasama S, Kaneko Y, Yokoyama T, Murakami M, Kurabayashi M
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Journal Title
European Heart Journal: Acute Cardiovascular Care
Volume: 印刷中
Issue: 6
Pages: 561-569
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] CD36 is indispensable for thermogenesis under conditions offasting and cold stress.2015
Author(s)
Putri M, Syamsunarno MR, Iso T, Yamaguchi A, Hanaoka H, Sunaga H, Koitabashi N, Matsui H, Yamazaki C, Kameo S, Tsushima Y, Yokoyama T, Koyama H, Abumrad NA, Kurabayashi M.
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Journal Title
Biochem Biophys Res Commun.
Volume: 457
Issue: 4
Pages: 520-525
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Vildagliptin Attenuates Cardiac Hypertrophy and Improves Ventricular Efficiency Through FGF21 Expression in Pressure-overloaded Mouse Heart2016
Author(s)
Nozomi Furukawa, Norimichi Koitabashi, Hiroaki Sunaga, Masaru Obokata, Yogi Umbarawan, Mas RAA Syamsunarno, Tatsuya Iso, Akiko Yamguchi, Hiroki Matsui, Tomoyuki Yokoyama, Masahiko Kurabayashi
Organizer
第89回アメリカ心臓協会学術集会
Place of Presentation
アメリカ・ニューオリンズ
Year and Date
2016-11-13
Related Report
Int'l Joint Research
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[Presentation] A Massive Increase in Serum Levels of Fatty Acid Binding Protein 4 in Patients With Acute Myocardial Infarction Complicated by Out-of- Hospital Cardiac Arrest Due to Ventricular Fibrillation2016
Author(s)
Hiroaki Sunaga, Tatsuya Iso, Masaru Obokata, Yoshiaki Ohyama, Norimichi Koitabashi, Ryuichi Funada, Noriaki Takama, Hiroki Matsui, Tomoyuki Yokoyama, Masami Murakami, Masahiko Kurabayashi
Organizer
第89回アメリカ心臓協会学術集会
Place of Presentation
アメリカ・ニューオリンズ
Year and Date
2016-11-13
Related Report
Int'l Joint Research
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[Presentation] Early Increase in Serum Fatty Acid Binding Protein 4 Levels in Patients with Acute Myocardial Infarction: Lipolysis as a Novel Marker for Myocardial Ischemia2014
Author(s)
Hiroaki Sunaga, Yoshiaki Ohyama, Masaru Obokata, Tatsuya Iso, Tomoka Kawaguchi,Norimichi Koitabashi, Ryuichi Funada, Noriaki Takama, Mas Rizky A.A Syamsunarno,Hiroki Matsui, Tomoyuki Yokoyama,Masahiko Kurabayash
Organizer
American Heart Asociation, Scientific Sessions 2014
Place of Presentation
アメリカ、シカゴ
Year and Date
2014-11-15 – 2014-11-19
Related Report
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