| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
We examined the role of Elongation of long chain fatty acid member 6 (Elovl6) which is a rate-limiting enzyme catalysing the elongation of saturated and monounsaturated fatty acids on the development of pulmonary emphysema using Elobl6-deficient mice. In the early stage of emphysema, the expression of Elovl6 was increased in alveolar type II epithelial cells, and increased Elovl6 induced derangement of fatty acid profile and exacerbated pulmonary emphysema. On the other hand, in the chronic phase of emphysema, the expression of Elovl6 returned to the level of normal mice, and the fatty acid profile of lung was similar to normal mice. Our findings demonstrate a previously unappreciated role for Elovl6 in the pathogenesis of pulmonary emphysema.
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