| Project/Area Number |
26461192
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
Suzuki Tomoko 福島県立医科大学, 公私立大学の部局等, 准教授 (10400342)
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| Co-Investigator(Kenkyū-buntansha) |
棟方 充 福島県立医科大学, 医学部, 教授 (00209991)
谷野 功典 福島県立医科大学, 医学部, 准教授 (10443863)
王 新涛 福島県立医科大学, 医学部, 助教 (00448630)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 肺線維症急性増悪 / 特発性肺線維症急性増悪 / PAR-2アンタゴニスト |
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| Outline of Final Research Achievements |
To investigate a potential of PAR-2 antagonist for treatment of idiopathic pulmonary fibrosis-acute exacerbation, we studied anti-inflammation and anti-fibrotic effects for bleomycin-treated mice.
The number of lymphocytes in bronchoalveolar lavage fluid (BALF) of BLM mice treated intranasally with PAR-2 inhibiting peptide (IP) was significantly reduced, and infiltrations of inflammatory cells in lung were also suppressed. Total collagen in lungs of PAR-2IP-treated BLM mice was significantly reduced. Furthermore, Yimentin on PAR-2IP-treated BLM mice was less expressed than in BLM mice. Therefore, PAR-2 IP has anti-inflammatory effect, and inhibits BLM-induced fibrosis through the control of epithelial-mesenchymal transition.
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