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The molecular mechanism of drug-induced lung injury caused by the genetic polymorphism of MUC4

Research Project

Project/Area Number 26461196
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionJichi Medical University (2016)
Saitama Medical University (2014-2015)

Principal Investigator

Ohta Hiromitsu  自治医科大学, 医学部, 講師 (40451562)

Co-Investigator(Kenkyū-buntansha) 萩原 弘一  埼玉医科大学, 医学部, 客員教授 (00240705)
海老名 雅仁  東北医科薬科大学, 医学部, 教授 (10280885)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords薬剤性肺障害 / 特発性間質性肺炎急性増悪 / EGFR-TKI / びまん性肺胞障害 / ムチン / MUC4のシークエンス / MUC4発現ベクター / 初代気道上皮細胞 / びまん性肺胞上皮障害
Outline of Final Research Achievements

Drug induced lung injury and acute exacerbation of idiopathic interstitial pneumonia are more frequent among Japanese people than people in other countries. The pathology of these disease is diffuse alveolar damage (DAD), and common genetic factors are assumed. We had accumulated Japanese patients with DAD. Mucin 4 (MUC4) was identified as a candidate gene, by carrying out the exome analysis about these patients and comparing with Caucasian, Chinese and healthy Japanese. Genetic polymorphisms of MUC4 among the patients with DAD and healthy subjects were analyzed, and cloned to prepare an expression vector for every genetic polymorphism of MUC4. Furthermore, primary culture cells of the bronchial epithelium were established form the resected lungs for lung cancer and the like, in order to reveal functional differences of the bronchial epithelial cells between patients with DAD and healthy subjects.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (2 results)

All 2017 2016

All Journal Article (1 results) Presentation (1 results)

  • [Journal Article] 肺循環・肺損傷 ムチンと気道上皮防御機構2017

    • Author(s)
      太田洋充、萩原弘一
    • Journal Title

      分子呼吸器病学

      Volume: 21 Pages: 61-63

    • Related Report
      2016 Annual Research Report
  • [Presentation] 当院の進展型肺小細胞癌における間質性肺炎の有無の影響及び予後因子の検討2016

    • Author(s)
      岩井悠紀、渡辺恭孝、工藤史明、三輪千尋、長井良昭、太田洋充、小山信一郎、萩原弘一、小山信之
    • Organizer
      第57回日本肺癌学会学術集会
    • Place of Presentation
      福岡(福岡サンパレス、福岡国際センター)
    • Year and Date
      2016-12-19
    • Related Report
      2016 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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