The molecular mechanism of drug-induced lung injury caused by the genetic polymorphism of MUC4
| Project/Area Number |
26461196
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Jichi Medical University (2016)
Saitama Medical University (2014-2015) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
萩原 弘一 埼玉医科大学, 医学部, 客員教授 (00240705)
海老名 雅仁 東北医科薬科大学, 医学部, 教授 (10280885)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 薬剤性肺障害 / 特発性間質性肺炎急性増悪 / EGFR-TKI / びまん性肺胞障害 / ムチン / MUC4のシークエンス / MUC4発現ベクター / 初代気道上皮細胞 / びまん性肺胞上皮障害 |
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| Outline of Final Research Achievements |
Drug induced lung injury and acute exacerbation of idiopathic interstitial pneumonia are more frequent among Japanese people than people in other countries. The pathology of these disease is diffuse alveolar damage (DAD), and common genetic factors are assumed. We had accumulated Japanese patients with DAD. Mucin 4 (MUC4) was identified as a candidate gene, by carrying out the exome analysis about these patients and comparing with Caucasian, Chinese and healthy Japanese. Genetic polymorphisms of MUC4 among the patients with DAD and healthy subjects were analyzed, and cloned to prepare an expression vector for every genetic polymorphism of MUC4. Furthermore, primary culture cells of the bronchial epithelium were established form the resected lungs for lung cancer and the like, in order to reveal functional differences of the bronchial epithelial cells between patients with DAD and healthy subjects.
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Report
(4 results)
Research Products
(2 results)
