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MicroRNA and exosome in interstitial pneumonia

Research Project

Project/Area Number 26461204
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionNippon Medical School

Principal Investigator

Kunugi Shinobu  日本医科大学, 医学部, 講師 (30350036)

Co-Investigator(Kenkyū-buntansha) 寺崎 泰弘  日本医科大学, 医学部, 准教授 (50332870)
Co-Investigator(Renkei-kenkyūsha) MIYAKE KOUICHI  日本医科大学, 医学部, 准教授 (90267211)
NAGASAKA SHINYA  日本医科大学, 医学部, 助教 (00573239)
TERASAKI MIKA  日本医科大学, 医学部, 助教 (50372785)
SEIKE MASAHIRO  日本医科大学, 医学部, 准教授 (30366687)
ISHIKAWA ARIMI  日本医科大学, 医学部, 研究員 (40598992)
KUWAHARA NAOMI  日本医科大学, 医学部, 研究員 (00599011)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords気管支肺胞洗浄液 / マイクロRNA / エクソソーム / II型肺胞上皮 / 間質性肺炎 / miRNA / エクソゾーム / microRNA
Outline of Final Research Achievements

We performed micro RNA analysis of serum, bronchoalveolar lavage, and lung tissue of bleomycin-induced pneumonitis in mice. Particularly, We analyzed exosomal franction and others fraction of bronchoalveolar lavage.In fibrotic stage,the elevation of miR-150 were confirmed.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (8 results)

All 2017 2016 2015

All Journal Article (6 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 6 results,  Acknowledgement Compliant: 1 results,  Open Access: 4 results) Presentation (1 results) Book (1 results)

  • [Journal Article] Localized pulmonary crystal-storing histiocytosis complicating pulmonary mucaosa-associated lymphoid tissue lymphoma presenting with multiple mass lesion.2017

    • Author(s)
      Kokuho N, Terasaki Y, Kunugi S, Onda N, Urushiyama H, Terasaki M, Hino M, Gemma A, Hatori T, Shimizu A.
    • Journal Title

      Human Pathology

      Volume: 印刷中 Pages: 180-186

    • DOI

      10.1016/j.humpath.2016.10.028

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Pulmonary mucosa-associated lymphoid tissue lymphoma associated with pulmonary sarcoidosis: a case report and literature review.2016

    • Author(s)
      Kokuho N, Terasaki Y, Urushiyama H, Terasaki M, Kunugi S, Morimoto T, Azuma A, Usuda J, Gemma A, Eishi Y, Shimizu A.
    • Journal Title

      Hum Pathol.

      Volume: 51 Pages: 57-63

    • DOI

      10.1016/j.humpath.2015.12.019

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Interstitial lung disease associated with amrubicin chemotherapy in patients with lung cancer: a single institutional study.2016

    • Author(s)
      Miura Y1, Saito Y2, Atsumi K1, Takeuchi S1, Miyanaga A1, Mizutani H, Minegishi Y, Noro R, Seike M, Kunugi S, Kubota K, Gemma A.
    • Journal Title

      Jpn J Clin Oncol. 2016 Jul;46(7):674-80.

      Volume: 46(7) Issue: 7 Pages: 674-680

    • DOI

      10.1093/jjco/hyw043

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Role of α1 and α2 chains of type IV collagen in early fibrotic lesions of idiopathic interstitial pneumonias and migration of lung fibroblasts.2015

    • Author(s)
      Urushiyama H, Terasaki Y, Nagasaka S, Terasaki M, Kunugi S, Nagase T, Fukuda Y, Shimizu A.
    • Journal Title

      Lab Invest

      Volume: 95 Issue: 8 Pages: 872-885

    • DOI

      10.1038/labinvest.2015.66

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effective Crizotinib schedule for an elderly patient with ALK rearranged non-small-cell lung cancer: a case report.2015

    • Author(s)
      Fukuizumi A, Miyanaga A, Seike M, Kato Y, Nakamichi S, Chubachi K, Matsumoto M, Noro R, Minegishi Y, Kunugi S, Kubota K, Gemma A
    • Journal Title

      BMC Res Notes.

      Volume: 8 Issue: 1 Pages: 165-165

    • DOI

      10.1186/s13104-015-1126-8

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epicardial Catheter Ablation of Ventricular Tachycardia in No Entry Left Ventricle: Mechanical Aortic and Mitral Valves2015

    • Author(s)
      Soejima K, Nogami A, Sekiguchi Y, Harada T, Satomi K, Hirose T, Ueda A, Miwa Y, Sato T, Nishio S, Shirai Y1, Kowase S, Murakoshi N, Kunugi S, Murata H, Nitta T, Aonuma K, Yoshino H
    • Journal Title

      Circulation: Arrhythmia and Electrophysiology

      Volume: 8 Issue: 2 Pages: 381-389

    • DOI

      10.1161/circep.114.002517

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 血液疾患に2次性肺胞蛋白症を呈した剖検肺2症例の検討2016

    • Author(s)
      功刀 しのぶ, 寺﨑 泰弘, 呉 壮香, 許田 典男, 國保 成暁, 寺崎 美佳, 清水 章
    • Organizer
      第105回日本病理学会総会
    • Place of Presentation
      仙台国際センター 展示棟
    • Related Report
      2016 Annual Research Report
  • [Book] 集中講義 病理学2016

    • Author(s)
      功刀 しのぶ
    • Total Pages
      283
    • Publisher
      MEDICAL VIEW
    • Related Report
      2016 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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