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Beneficial effects of Galectin-9 on allergen-specific sublingual immunotherapy in a mite antigen-induced mouse model of chronic asthma

Research Project

Project/Area Number 26461205
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionKawasaki Medical School

Principal Investigator

Katoh Shigeki  川崎医科大学, 医学部, 講師 (10295206)

Research Collaborator IKEDA Masaki  川崎医科大学, 医学部, 大学院生
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords気管支喘息 / 抗原特異的舌下免疫療法 / ガレクチン-9 / マウス慢性喘息モデル / ガレクチン9 / 舌下免疫療法 / 制御性T細胞 / マウス
Outline of Final Research Achievements

Allergen-specific sublingual immunotherapy (SLIT) is a disease-modifying treatment for allergic asthma. Galectin-9 (Gal-9) acts as an immunomodulator in excessive immunologic reactions by expanding regulatory T cells (Treg) and enhancing transforming growth factor (TGF)-β signaling. We investigated the efficacy of sublingually administered Gal-9 to a specific allergen in a mite allergen-induced mouse model of chronic asthma. SLIT in the presence of Gal-9 significantly reduced airway hyperresponsiveness (AHR); early asthmatic response (EAR); number of eosinophils in the bronchoalveolar lavage fluid (BALF); and serum IgE levels. BALF TGF-β levels were significantly increased in the presence of Gal-9. Treg depletion blocked the inhibitory effects of Gal-9 on the EAR, AHR, eosinophilic airway inflammation, and serum IgE levels, and suppressed BALF TGF-β levels. Gal-9 exhibited beneficial effects of SLIT in a mite allergen-induced mouse model of chronic asthma.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (12 results)

All 2017 2016 2015

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (9 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Beneficial effects of Galectin-9 on allergen-specific sublingual immunotherapy in a Dermatophagoides farinae-induced mouse model of chronic asthma2017

    • Author(s)
      Masaki Ikeda, Shigeki Katoh, Hiroki Shimizu, Akira Hasegawa, Katsuyo Ohashi-Doi, Mikio Oka
    • Journal Title

      Allergology International

      Volume: 印刷中

    • NAID

      130005858794

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Development of two types of mite-allergen induced murine models of chronic asthma with different severity2016

    • Author(s)
      Masaki Ikeda, Shigeki Katoh, Hiroki Shimizu, Mikio Oka
    • Journal Title

      Kawasaki Medical Journal

      Volume: 42 Pages: 1-7

    • DOI

      10.11482/KMJ-E42(1)1

    • NAID

      110010041931

    • ISSN
      0385-0234, 2434-3404
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of two types of mite-allergen induced murine models of chronic asthma with different severity.2016

    • Author(s)
      Masaki Ikeda, Shigeki Katoh, Hiroki Shimizu, Mikio Oka
    • Journal Title

      Kawasaki Medical Journal

      Volume: 42 Pages: 1-7

    • NAID

      110010041931

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] ダニ抗原誘発マウス慢性喘息モデルにおける新規舌下免疫療法の検討2017

    • Author(s)
      池田征樹、加藤茂樹、岡三喜男
    • Organizer
      第56回日本呼吸器学会学術講演会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Year and Date
      2017-04-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] ダニ抗原誘発マウス慢性喘息モデルにおける新規舌下免疫療法の検討2016

    • Author(s)
      池田征樹、加藤茂樹、長谷川輝、土井雅津代、岡三喜男
    • Organizer
      第65回日本アレルギー学会学術大会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Year and Date
      2016-06-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] Galectin-9 enhances the effect of allergen specific sublingual immunotherapy in a Dermatophagoides farinae-induced mouse model of chronic asthma2016

    • Author(s)
      Masaki Ikeda, Shigeki Katoh, Hiroki Shimizu, Yoshihiro Ohue, Akira Hasegawa, Katsuyo Ohashi-Doi, Mikio Oka
    • Organizer
      European Academy of Allergy and Clinical Immunology
    • Place of Presentation
      Vienna( Austria)
    • Year and Date
      2016-06-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ダニ抗原誘発マウス慢性喘息モデルにおける新規舌下免疫療法の有用性2016

    • Author(s)
      池田征樹、加藤茂樹、長谷川輝、土井雅津代、岡三喜男
    • Organizer
      第56回日本呼吸器学会学術講演会
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2016-04-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] ダニ抗原誘発マウス慢性喘息モデルにおける新規舌下免疫療法の有効性2016

    • Author(s)
      池田征樹、加藤茂樹、長谷川輝、土井雅津代、岡三喜男
    • Organizer
      第56回日本呼吸器学会学術講演会
    • Place of Presentation
      国立京都国際会館(京都市、左京区)
    • Year and Date
      2016-04-08
    • Related Report
      2015 Research-status Report
  • [Presentation] ダニ抗原誘発マウス慢性喘息モデルにおける新規舌下免疫療法の検討2016

    • Author(s)
      池田征樹、加藤茂樹、岡三喜男
    • Organizer
      アレルギー・好酸球研究会2016
    • Place of Presentation
      学術総合センター(東京都)
    • Related Report
      2016 Annual Research Report
  • [Presentation] ダニ抗原誘発マウス慢性喘息モデルにおける舌下免疫療法の検討2015

    • Author(s)
      池田征樹、加藤茂樹、清水大樹、鈴木啓介、土井雅津代、岡三喜男
    • Organizer
      第64回日本アレルギー学会学術大会
    • Place of Presentation
      グランドプリンスホテル新高輪国際館パミール(東京都・港区)
    • Year and Date
      2015-05-26 – 2015-05-28
    • Related Report
      2014 Research-status Report
  • [Presentation] ダニ抗原誘発マウス慢性喘息モデルにおける舌下免疫療法の検討2015

    • Author(s)
      池田征樹、加藤茂樹、鈴木啓介、土井雅津代、岡三喜男
    • Organizer
      第64回日本アレルギー学会学術大会
    • Place of Presentation
      グランドプリンスホテル新高輪国際館パミール(東京都、港区)
    • Year and Date
      2015-05-26
    • Related Report
      2015 Research-status Report
  • [Presentation] ダニ抗原誘発慢性喘息マウスモデルを用いた気管支喘息の新規根治療法の開発2015

    • Author(s)
      池田征樹、加藤茂樹、清水大樹、鈴木啓介、土井雅津代、岡三喜男
    • Organizer
      第55回日本呼吸器学会学術講演会
    • Place of Presentation
      東京国際フォーラム(東京都・千代田区)
    • Year and Date
      2015-04-17 – 2015-04-19
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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