Analysis of the cyst progress associated with hypertension in in ADPKD
| Project/Area Number |
26461207
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Kidney internal medicine
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
Nishio Saori 北海道大学, 大学病院, 講師 (90463736)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 多発性嚢胞腎 / 腎内RAS / 高血圧 / 腎内RAS系 / 血管内皮機能 / 尿中アンジオテンシノーゲン / レニン・アンギオテンシン系 |
|---|
| Outline of Final Research Achievements |
Hypertension is a well-recognized complication of autosomal dominant polycystic kidney disease (ADPKD). Hypertension relates to progressive kidney enlargement and is significant independent risk factor for progression to end-stage renal disease. However, the definite mechanisms leading to hypertension in ADPKD are not well understood. The purpose of this study is to examine the effects of antihypertensive drugs for pkd1 conditional knockout mice, and the participation of intrarenal RAS in ADPKD. We generated the pkd1 conditional knockout mice (Pkd1 KO mice). To evaluate the effects of antihypertensive drugs, Pkd1 KO mice were treated by amlodipine or olmesartan or aliskiren, or vehicle for 12 weeks. Aliskiren treatment significantly reduced renal cystic index. Aliskiren treatment group improved tubulointerstital fibrosis. Renin, Ang II and AGT expression were increased significantly in cystic kidneys. Aliskiren prevented intrarenal RAS activation and cystic progression.
|
Report
(4 results)
Research Products
(17 results)
-
-
-
-
[Journal Article] Transcatheter arterial embolization with ethanol injection in symptomatic patients with enlarged polycystic kidneys.2015
Author(s)
Sakuhara Y, Nishio S, Morita K, Abo D, Hasegawa Y, Yuasa N, Mochizuki T, Soyama T, Oba K, Shirato H, Kudo K
-
Journal Title
Radiology
Volume: 277(1)
Issue: 1
Pages: 277-285
DOI
Related Report
Peer Reviewed
-
[Journal Article] Outcomes of primary nephrotic syndrome in elderly Japanese: retrospective analysis of the Japan Renal Biopsy Registry (J-RBR)2015
Author(s)
Yokoyama H, Sugiyama H, Narita I, Saito T, Yamagata K, Nishio S, Fujimoto S, Mori N, Yuzawa Y, Okuda S, Maruyama S, Sato H, Ueda Y, Makino H, Matsuo S
-
Journal Title
Clin Exp Nephrol.
Volume: 19（3）
Pages: 496-505
Related Report
Peer Reviewed
-
[Journal Article] Outcomes of primary nephrotic syndrome in elderly Japanese: retrospective analysis of the Japan Renal Biopsy Registry (J-RBR)2014
Author(s)
Yokoyama H, Sugiyama H, Narita I, Saito T, Yamagata K, Nishio S, Fujimoto S, Mori N, Yuzawa Y, Okuda S, Maruyama S, Sato H, Ueda Y, Makino H, Matsuo S.
-
Journal Title
Clin Exp Nephrol
Volume: Epub ahead
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
-
[Presentation] Efficacy and safety of tolvaptan on autosomal dominant polycystic kidney disease (ADPKD) in late-stage CKD2016
Author(s)
Hattanda F, Makita M, Kawashima K, Kondo K, Ishikawa Y, Kusunoki Y, Matsuoka N, Yamamoto J, Nakagaki T, Nishio S, Atsumi T
Organizer
The 53rd ERA-EDTA Congress
Place of Presentation
Vienna, Austria
Year and Date
2016-05-21
Related Report
Int'l Joint Research
-
[Presentation] Effect of tolvaptan on a body water balance in patients with autosomal dominant polycystic kidney disease2016
Author(s)
Makita M, Nishio S, Kondo K, Kawashima K, Ishikawa Y, Hattanda F, Kusunoki Y, Matsuoka N, Yamamoto J, Nakagaki T, Takeda H, Atsumi T.
Organizer
The 53rd ERA-EDTA Congress
Place of Presentation
Vienna, Austria
Year and Date
2016-05-21
Related Report
Int'l Joint Research
-
-
-
-
-
-
-
