| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Outline of Final Research Achievements |
Using doxycycline (DOX)-induced Histone 2B-GFP mice, we here investigated the role of GFP-labeled renal stem cells in regeneration processes of the kidneys after injury. We could detect GFP-labeled renal stem cells in the kidneys of these mice after a short DOX pulse and a long chase period. GFP-labeled renal stem cells actively contributed to the tubular regeneration of the kidneys after injury. In this process, renal stem cells showed uneven cell division, which is one of the characteristics of adult tissue stem cells. In aging mice, the number of GFP-labeled renal stem cells significantly decreased compared to that in young mice. These data suggest that the activation of renal stem cells is an effective and promising strategy to enhance the regeneration process of the kidney after a variety of insults.
|
