The role of Tcf21 in Podocytes in Health and Diseases
| Project/Area Number |
26461214
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Kidney internal medicine
|
|---|
| Research Institution | Chiba University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
竹本 稔 千葉大学, 大学院医学研究院, 特任教授 (60447307)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | ポドサイト / 転写因子 / Tcf21 / 糖尿病性腎症 / 尿蛋白 / インスリン感受性 |
|---|
| Outline of Final Research Achievements |
We aimed to clarify the role of the transcription factor Tcf21 in Podocytes and in Stromal cells. In order to circumvent the early lethality of Tcf21 KO mice, we established an tetracycline-induced podocyte specific Tcf21 KO mice and stromal specific Tcf21 KO mice. The podocyte specific Tcf21 defect in adult mice did not result in proteinuria. But, by induction of diabetes using Streptozotocin, the mutant mice showed severe proteinuria after 12 weeks. In addition, the stroma specific Tcf21 KO mice showed severe defect in collecting duct and loop of Henle formation.
|
Report
(4 results)
Research Products
(31 results)
-
-
-
[Journal Article] Pituitary adenylate cyclase-activating polypeptide protects glomerular podocytes from inflammatory injuries.2015
Author(s)
Sakamoto K, Kuno K, Takemoto M, He P, Ishikawa T, Onishi S, Ishibashi R, Okabe E, Shoji M, Hattori A, Yamaga M, Kobayashi K, Kawamura H, Tokuyama H, Maezawa Y, Yokote K
-
Journal Title
J Diabetes Res
Volume: 印刷中
Pages: 727152-727152
DOI
Related Report
Peer Reviewed / Open Access
-
-
[Journal Article] Loss of the podocyte-expressed transcription factor Tcf21/Pod1 results in podocyte differentiation defects and FSGS.2014
Author(s)
Maezawa Y, Onay T, Scott RP, Keir LS, Dimke H, Li C, Eremina V, Maezawa Y, Jeansson M, Shan J, Binnie M, Lewin M, Ghosh A, Miner JH, Vainio SJ, Quaggin SE.
-
Journal Title
J Am Soc Nephrol.
Volume: 11
Issue: 11
Pages: 2459-70
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
-
[Presentation] Maldevelopment of Papillae in Kidneys Lacking Tcf21 in Stroma Reveals an Essential Crosstalk between Stroma, Nephrogenic Tubules, and Collecting Ducts.2016
Author(s)
Shintaro Ide, Yoshiro Maezawa, Rizaldy Scott, Tuncer Onay, Yoshihiro Akimoto, Kana Ide, Minoru Takemoto, Susan E. Quaggin, and Koutaro Yokote
Organizer
American Society of Nephrology, Kidney Week 2016
Place of Presentation
McCormic Place,Chicago, USA
Year and Date
2016-11-17
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] The bHLH transcription factor Tcf21 regulates Podocyte function.2014
Author(s)
Yoshiro Maezawa, Tuncer Onay , Rizaldy Scott , Lindsay Keir , Henrik Dimke , Chengjin Li , Vera Eremina , Yuko Maezawa , Marie Jeansson , Asish Ghosh , Jeffrey Miner , Seppo Vainio , Susan Quaggin
Organizer
14th International Vascular Biology Meeting
Place of Presentation
みやこめっせ(京都府京都市)
Year and Date
2014-04-14 – 2014-04-17
Related Report
-
